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Abraxane

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Abraxane uses and description

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Abraxane - Abraxane protein-bound is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Abraxane protein-bound is used in the treatment of breast cancer.

Abraxane protein-bound is usually given after other cancer medicines have been tried without successful treatment.

Abraxane protein-bound may also be used for purposes not listed in this medication guide.

Used for: Treating breast cancer in certain patients. It may also be used for other types of cancer as determined by your doctor.

Abraxane is a chemotherapy medicine. It works by slowing or stopping cancer cells from dividing and growing, so they eventually die.

Abraxane protein-bound is a cancer (antineoplastic) medication. Abraxane protein-bound interferes with the growth of cancer cells and slows their growth and spread in the body.

Abraxane protein-bound is used in the treatment breast cancer.

Indications: breast cancer

Abraxane is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific Yew tree, Taxus brevifolia and named it \'taxol\'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to \'paclitaxel\' and the BMS compound is sold under the trademark \'TAXOL\'. In this formulation, Abraxane is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which Abraxane is bound to albumin, is sold under the trademark Abraxane.

Abraxane is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi\'s sarcoma. Abraxane is also used for the prevention of restenosis.

indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary. As first-line therapy, Abraxane is indicated in combination with cisplatin. Paclitaxel is indicated for the adjuvant treatment of node-positive breast cancer administered sequentially to standard doxorubicin-containing combination chemotherapy. In the clinical trial, there was an overall favorable effect on disease-free and overall survival in the total population of patients with receptor-positive and receptor-negative tumors, but the benefit has been specifically demonstrated by available data (median follow-up 30 months) only in the patients with estrogen and progesterone receptor- negative tumors. Abraxane is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated. Paclitaxel in combination with cisplatin, is indicated for the first-line treatment of non- small cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy. Paclitaxel is indicated for the second-line treatment of AIDS-related Kaposi’s sarcoma.

Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Albumin comprises about half of the blood serum protein. It is soluble and monomeric.

The gene for albumin is located on chromosome 4 and mutations in this gene can result in various anomalous proteins. The human albumin gene is 16,961 nucleotides long from the putative 'cap' site to the first poly(A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain.

Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin.

The reference range for albumin concentrations in blood is 30 to 50 g/L. It has a serum half-life of approximately 20 days. It has a molecular mass of 67 kDa.

Abraxane is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific Yew tree, Taxus brevifolia and named it 'taxol'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, Abraxane is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which Abraxane is bound to albumin, is sold under the trademark Abraxane.

Abraxane is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Abraxane is also used for the prevention of restenosis.

Active ingredients: Paclitaxel
Unit description, dosagePrice, USD
Injectable; Injection; Paclitaxel 100 mg
1's$ 308.15
Injectable; Infusion; Paclitaxel 100 mg / ml
Abraxane Paclitaxel 100 mg, Humanalbumin 900 mg/20 mL. VIAL / 1$ 308.15
Abraxane Paclitaxel 100 mg, humanalbumin 900 mg/20 mL. INJ / 20ml$ 308.15

List of abraxane brand and generic drugs

Abitaxel
Injectable; Injection; Paclitaxel 6 mg / ml
Aclixel (Mexico)
Injectable; Injection; Paclitaxel 6 mg / ml
ADPAXIL (India)
30 mg x 1's
100 mg x 1's
260 mg x 1's
300 mg x 1's
Adpaxil 30mg VIAL / 1
Adpaxil 100mg VIAL / 1
Adpaxil 260mg VIAL / 1
Adpaxil 300mg VIAL / 1
ALTAXEL (India)
ALTAXEL Injection / 30mg (1 vial units)$ 38.89
ALTAXEL Injection / 200mg (1 vial units)$ 200.93
ALTAXEL Injection / 300mg (1 vial units)$ 202.78
ALTAXEL Injection / 100mg (1 vial units)$ 101.85
Altaxel 30mg/5ml VIAL / 1$ 38.89
Altaxel 100mg/16.7ml VIAL / 1$ 101.85
Altaxel 260mg/43.4ml VIAL / 1$ 200.93
Altaxel 300mg/50ml VIAL / 1$ 202.78
30 mg x 5 mL x 1's$ 38.89
100 mg x 16.7 mL x 1's$ 101.85
260 mg x 43.4 mL x 1's$ 200.93
300 mg x 50 mL x 1's$ 202.78
Injectable; Injection; Paclitaxel 6 mg / ml
Anzafax (Pakistan)
Anzatax (Singapore)
Injectable; Injection; Paclitaxel 6 mg / ml
Anzatax (onco-tain vial) 30 mg/5 mL x 1's
Anzatax 150 mg/25 mL x 1's$ 408.00
Anzatax 300 mg/50 mL x 1's
Anzatax (vial) 30 mg/5 mL x 1's
Anzatax 100 mg/16.7 mL x 1's
Anzatax 30 mg/5 mL x 1's$ 86.70
Anzatax (Onco-Tain ) 30 mg/5 mL x 1's
Anzatax Paclitaxel (Taiwan)
Anzatax Paclitaxel 6 mg/1 mL x 1's
Apo-Paclitaxel Injectable
Injectable; Injection; Paclitaxel 6 mg / ml
Asotax (Argentina, Mexico)
Injectable; Injection; Paclitaxel 6 mg / ml
Axitaxel (Germany)
Bendatax (Germany)
BETAXEL (India)
BETAXEL Injection / 100mg (16.7ml units)$ 111.00
BETAXEL Injection / 30mg (5ml units)$ 38.89
30 mg x 5 mL x 5ml$ 38.89
100 mg x 17 mL x 16.7ml$ 111.00
Betaxel 30mg/5ml VIAL / 5ml$ 38.89

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