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Actulin uses and description

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Actulin - Pharmacology: Decreases blood glucose by stimulating insulin release from the pancreas.

Indication: Adjunct to diet and exercise to lower blood glucose in patients with noninsulindependent diabetes mellitus (type 2) whose hyperglycemia cannot be controlled by diet and exercise alone. Can be used with metformin or thiazolidinediones (eg, rosiglitazone) when hyperglycemia cannot be controlled by exercise, diet, and monotherapy with metformin, sulfonylureas, repaglinide, or thiazolidinediones.

Actulin is an oral diabetes medicine that helps control blood sugar levels. This medication lowers blood sugar by causing the pancreas to produce insulin.

Actulin is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with Actulin if needed.

Actulin may also be used for purposes not listed in this medication guide.

Insulin secretion by pancreatic β cells is partly controlled by cellular membrane potential. Membrane potential is regulated through an inverse relationship between the activity of cell membrane ATP-sensitive potassium channels (ABCC8) and extracellular glucose concentrations. Extracellular glucose enters the cell via GLUT2 (SLC2A2) transporters. Once inside the cell, glucose is metabolized to produce ATP. High concentrations of ATP inhibit ATP-sensitive potassium channels causing membrane depolarization. When extracellular glucose concentrations are low, ATP-sensitive potassium channels open causing membrane repolarization. High glucose concentrations cause ATP-sensitive potassium channels to close resulting in membrane depolarization and opening of L-type calcium channels. The influx of calcium ions stimulates calcium-dependent exocytosis of insulin granules. Actulin increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner.

Actulin helps to treat diabetes by keeping your blood sugar in control. Actulin stimulates the pancreas to release insulin which helps lower the high blood sugar level that occurs after each meal. Actulin is meant to be taken as part of a complete diabetes care programme that should include exercise, a healthy diet and regular monitoring of blood sugar levels.

Oral Type 2 DM

Adult: Usual initial dose: 0.5 mg, taken within 30 minutes of main meals. Initial doses of 1 or 2 mg may be used in patients who have had previous hypoglycaemic treatment. May adjust dose at intervals of 1-2 wk, up to 4 mg before meals. Max dose: 16 mg daily. Hepatic impairment: May require longer intervals between dosage adjustments.

Indications: Type 2 DM.

Active ingredients: Repaglinide
Unit description, dosagePrice, USD

List of actulin brand and generic drugs

Dexanorm (Indonesia)
Dexanorm 0.5 mg x 5 x 10's
Dexanorm 0.5 mg x 10 x 10's
Dexanorm 1 mg x 5 x 10's$ 7.01
Dexanorm 1 mg x 10 x 10's
Dexanorm 2 mg x 5 x 10's
Dexanorm 2 mg x 10 x 10's
Dianorm Rephco (Bangladesh)
Diarepa (Bangladesh)
Dopect (Vietnam)
Dopect 0.5 mg x 2 Blister x 15 Tablet
Dopect 1 mg x 2 Blister x 15 Tablet
Dopect 2 mg x 2 Blister x 15 Tablet
Edinimel (Bulgaria)
Enyglid (Germany)
EUREPA (India)
EUREPA Capsule/ Tablet / 1mg (10 units)$ 1.60
EUREPA Capsule/ Tablet / 0.5mg (10 units)$ 0.98
EUREPA Capsule/ Tablet / 2mg (10 units)$ 2.53
Eurepa 0.5mg TAB / 10$ 1.04
Eurepa 1mg TAB / 10$ 1.70
Eurepa 2mg TAB / 10$ 2.63
0.5 mg x 10's$ 0.70
1 mg x 10's$ 1.15
2 mg x 10's$ 1.81
Eurepa-MF Repaglinide 1 mg, Metformin500 mg. TAB / 10$ 1.70
Eurepa-MF Repaglinide 2 mg, Metformin500 mg. TAB / 10$ 2.63
Fulaidi (China)
Glimet (Bangladesh)
Glimet Capsule/ Tablet / 2.5mg-250mg (10 units)$ 0.09
Glimet Capsule/ Tablet / 5mg-500mg (10 units)$ 0.14
Glimet Glipizide 2.5mg, Metformin HCI250mg TAB / 10$ 0.08
Glimet 30's
10's$ 0.08
Glimet 80+500 Tablet$ 0.07
Glimet 2.5+250 Tablet$ 0.01
Glinide 0.5
Gluconorm (Canada, Sri Lanka)
Tablet; Oral; Repaglinide 0.5 mg
Tablet; Oral; Repaglinide 1 mg
Tablet; Oral; Repaglinide 2 mg
Glukenil (Argentina)
Hipover (Chile, Peru)
Tablet; Oral; Repaglinide 0.5 mg
Tablet; Oral; Repaglinide 1 mg
Tablet; Oral; Repaglinide 2 mg
Ilgaper (Bulgaria, Poland)
Indorin (Bulgaria)

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