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Advant

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Advant uses and description

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Advant - Advant is an angiotensin II receptor antagonist. Advant keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Advant is used to treat high blood pressure (hypertension). It is sometimes given together with other blood pressure medications.

Advant is also used to treat kidney problems caused by type 2 (not insulin-dependent) diabetes.

Advant may also be used for purposes not listed in this medication guide.

Advant cilexetil is an ARB prodrug that is rapidly converted to candesartan, its active metabolite, during absorption from the gastrointestinal tract. Advant confers blood pressure lowering effects by antagonizing the hypertensive effects of angiotensin II via the RAAS. RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: type-1 angiotensin II receptor (AT1) and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.

Advant helps to keep your blood pressure under control. Advant relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Advant may also be used to treat other conditions, for example, heart failure.

Oral Hypertension

Adult: Initially, 8 mg once daily adjusted according to response.

Maintenance: 8 mg once daily. Max: 32 mg daily. Renal impairment: For patients with renal impairment or on haemodialysis: Initially, 4 mg once daily. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment. Oral Heart failure

Adult: Initially, 4 mg once daily, may double dose at intervals of not <2 wk. Max: 32 mg daily. Renal impairment: Reduce dose or discontinue treatment if renal function deteriorates. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment.

Indications:

Adult: PO HTN Initial: 8 mg once daily. Max: 32 mg/day. Heart failure Initial: 4 mg once daily. May double dose at intervals of not <2 wk. Max: 32 mg/day.

Oral Hypertension

Adult: Initially, 8 mg once daily adjusted according to response.

Maintenance: 8 mg once daily. Max: 32 mg daily. Renal impairment: For patients with renal impairment or on haemodialysis: Initially, 4 mg once daily. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment. Oral Heart failure

Adult: Initially, 4 mg once daily, may double dose at intervals of not <2 wk. Max: 32 mg daily. Renal impairment: Reduce dose or discontinue treatment if renal function deteriorates. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment. Special Populations: Patients with renal and hepatic impairment: Initially, 2 mg once daily.

Active ingredients: Candesartan
Unit description, dosagePrice, USD

List of advant brand and generic drugs

Acrux (Bulgaria)
Aldireca (Netherlands)
Amias (United Kingdom)
Tablet; Oral; Candesartan Cilexetil 16 mg
Tablet; Oral; Candesartan Cilexetil 2 mg
Tablet; Oral; Candesartan Cilexetil 32 mg
Tablet; Oral; Candesartan Cilexetil 4 mg
Tablet; Oral; Candesartan Cilexetil 8 mg
Tablets; Oral; Candesartan Cilexetil 16 mg
Tablets; Oral; Candesartan Cilexetil 2 mg
Tablets; Oral; Candesartan Cilexetil 32 mg
Tablets; Oral; Candesartan Cilexetil 4 mg
Tablets; Oral; Candesartan Cilexetil 8 mg
Amias "Orifarm" (Denmark)
Amias PharmaCoDane (Denmark)
AngioSart 4
Ao Bi Xin (China)
Arb (Bangladesh, South Korea)
Atacand (Algeria, Argentina, Aruba, Australia, Austria, Bahamas, Bahrain, Barbados, Belgium, Bermuda, Brazil, Bulgaria, Canada, Chile, Colombia, Costa Rica, Croatia (Hrvatska), Czech Republic, Denmark, Dominican Republic, Egypt, El Salvador, Estonia, Finland, France, Georgia, Germany, Ghana, Greece, Guatemala, Guyana, Haiti, Honduras, Hungary, Iceland, Ireland, Israel, Jamaica, Jordan, Kenya, Kuwait, Latvia, Lebanon, Lithuania, Luxembourg, Malaysia, Malta, Mexico, Netherlands, Netherlands Antilles, New Zealand, Nicaragua, Norway, Oman, Panama, Paraguay, Peru, Poland, Portugal, Qatar, Romania, Russian Federation, Saudi Arabia, Singapore, Slovakia, Slovenia, South Africa, South Korea, Spain, Sri Lanka, Sudan, Sweden, Switzerland, Trinidad & Tobago, Tunisia, Turkey, United Arab Emirates, United States, Uruguay, Venezuela, Zimbabwe)
Tablet; Oral; Candesartan Cilexetil 16 mg
Tablet; Oral; Candesartan Cilexetil 32 mg
Tablet; Oral; Candesartan Cilexetil 4 mg
Tablet; Oral; Candesartan Cilexetil 8 mg
Atacand 8 mg x 30's
Atacand 16 mg x 30's
Atacand 4 mg x 28's
Atacand 8 mg x 28's
Atacand 16 mg x 28's
Atacand Plus 28's
Atasart (Vietnam)
Atasart 8 mg x 4 Blister x 7 Tablet
Atasart 16 mg x 4 Blister x 7 Tablet
Ayra (Turkey)
Bilaten (Chile)
Tablet; Oral; Candesartan Cilexetil 16 mg
Tablet; Oral; Candesartan Cilexetil 8 mg
Blopress (Antigua & Barbuda, Aruba, Austria, Bahamas, Bahrain, Barbados, Bermuda, Brazil, Cayman Islands, Chile, China, Costa Rica, Ecuador, El Salvador, Germany, Grenada, Guatemala, Guyana, Haiti, Honduras, Hong Kong, Indonesia, Italy, Jamaica, Japan, Malaysia, Mexico, Netherlands Antilles, Nicaragua, Oman, Panama, Peru, Philippines, Portugal, Saint Lucia, Saint Vincent & The Grenadines, Spain, Suriname, Switzerland, Taiwan, Thailand, Trinidad & Tobago, Turks & Caicos Islands, Venezuela, Virgin Islands (British))
Tablet; Oral; Candesartan Cilexetil 16 mg
Tablet; Oral; Candesartan Cilexetil 32 mg
Tablet; Oral; Candesartan Cilexetil 4 mg
Tablet; Oral; Candesartan Cilexetil 8 mg
Blopress 8 mg x 28's$ 29.38
Blopress 16 mg x 28's$ 43.81
Blopress 8 mg x 4 Blister x 7 Tablet
Blopress 8 mg x 14's$ 14.74
Blopress 16 mg x 14's$ 19.41
Blopress 4 mg

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