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Alfametildopa

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Alfametildopa uses and description

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Alfametildopa - Used for: Treating high blood pressure. It may be used with other high blood pressure medicines. It may also be used for other conditions as determined by your doctor.

Alfametildopa is an alpha-2 receptor agonist. It reduces elevated blood pressure by relaxing and dilating (widening) blood vessels. Blood flows more freely and at a lower pressure through dilated blood vessels.

Alfametildopa lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax (widen) and your heart to beat more slowly and easily.

Alfametildopa is used to treat hypertension (high blood pressure).

Alfametildopa may also be used for purposes not listed in this medication guide.

Alfametildopa is an aromatic-amino-acid decarboxylase inhibitor in animals and in man. Only methyldopa, the L-isomer of alpha-methyldopa, has the ability to inhibit dopa decarboxylase and to deplete animal tissues of norepinephrine. In man the antihypertensive activity appears to be due solely to the L-isomer. About twice the dose of the racemate (DL-alpha-methyldopa) is required for equal antihypertensive effect. Alfametildopa has no direct effect on cardiac function and usually does not reduce glomerular filtration rate, renal blood flow, or filtration fraction. Cardiac output usually is maintained without cardiac acceleration. In some patients the heart rate is slowed. Normal or elevated plasma renin activity may decrease in the course of Alfametildopa therapy. Alfametildopa reduces both supine and standing blood pressure. Alfametildopa usually produces highly effective lowering of the supine pressure with infrequent symptomatic postural hypotension. Exercise hypotension and diurnal blood pressure variations rarely occur.

Oral Hypertension

Adult: Monotherapy: Initially, 250 mg bid-tid for 2 days; adjust according to response not more than every 2 days.

Maintenance: 0.5-2 g daily. Max: 3 g daily. Combination therapy: Initial dose should not exceed 500 mg daily in divided doses.

Child: Initially, 10 mg/kg or 300 mg/m 2 daily in 2-4 divided doses; increase as necessary. Max: 65 mg/kg, 2 g/m 2 or 3 g daily, whichever is least.

Elderly: Initially, 125 mg bid; gradually increase according to response. Max: 2 g daily. Renal impairment: May respond to smaller doses. Intravenous Hypertension

Adult: As methyldopate hydrochloride: 250-500 mg in 100 ml of 5% glucose injected over 30-60 min every 6 hr. Max: 1 g every 6 hr.

Child: As methyldopate hydrochloride: 20-40 mg/kg/24 hr or 0.6-1.2 g/m 2 /24 hr in equally divided doses every 6 hr. Max 65 mg/kg, 2 g/m 2 or 3 g daily, whichever is least. Renal impairment: May respond to smaller doses. Incompatibility: Incompatible with amphotericin B, methohexital.

Indications:

Adult: PO HTN Monotherapy: Initial: 250 mg 2-3 times/day for 2 days; adjust accordingly not more than every 2 days.

Maintenance: 0.5-2 g/day. Max: 3 g/day. IV As methyldopate HCl: 250-500 mg 6 hrly. Max: 1 g 6 hrly.

Active ingredients: Methyldopa
Unit description, dosagePrice, USD

List of alfametildopa brand and generic drugs

Alfamet (Turkey)
Almedopa (Taiwan)
Almedopa 250 mg
Almepan
Aloset
Alphadopa (India)
ALPHADOPA Capsule/ Tablet / 250mg (10 units)$ 0.44
Alphadopa 250mg TAB / 10$ 0.38
Tablets; Oral; Methyldopa 250 mg
250 mg x 10's$ 0.38
Alphamex
Amender
Apo-Methyldopa (Canada, Singapore, Vietnam)
Apo-Methyldopa 250 mg x 100 Tablet
Apo-Methyldopa 250 mg x 1000 Tablet
Apo-Methyldopa 125 mg x 100's
Apo-Methyldopa 250 mg x 1000's
Arcanadopa
Bayer 1440 L
Becanta
Bethyltax (Vietnam)
Bethyltax 250 mg x 10 Blister x 10 Tablet
Biotenzol
Cardiodopa
Datleal (Japan)
Dimipress
Domepa (Vietnam)
Domepa 250 mg x 10 Blister x 10 Tablet
Dopagen
Dopagrand (Argentina)
Dopagyt (India)
250 mg x 10's$ 0.28
Dopagyt 250mg TAB / 10$ 0.28
Dopagyt 250 mg Tablet$ 0.03
Dopamat 125
Dopamet (Bahrain, Cyprus, Egypt, Ethiopia, Indonesia, Iraq, Jordan, Kuwait, Lebanon, Libya, Qatar, Saudi Arabia, Sudan, United Arab Emirates, Yemen)
Tablet; Oral; Methyldopa 125 mg
Tablet; Oral; Methyldopa 250 mg
Tablet; Oral; Methyldopa 500 mg
Dopamet 250 mg x 100's$ 16.32
Dopamet 250 mg x 40's$ 13.00
Dopamet 250 mg x 80's
Dopamet Medochemie (Hong Kong)
Dopamet Medochemie 250 mg x 1,000's
Dopamethyperpax
Dopametil
Dopamide (Japan)
Dopanore (Tunisia)
Dopasian (Thailand)
Dopasian 125 mg x 1,000's$ 40.00
Dopasian 250 mg x 500's$ 40.00

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