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Alprostadil

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Alprostadil uses and description

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Alprostadil - Alprostadil is the medication of prostaglandin E1. This drug improves microcirculation and peripheral circulation, it has angioprotective action. With systemic administration causes relaxation of smooth muscle fibers, exerts vasodilating effect, reduces PR, lowers blood pressure. It is noted a reflex increase in cardiac output and heart rate. Improves the rheological properties of blood helping to increase the elasticity of red blood cells and reducing platelet aggregation and activity of neutrophils, increases the fibrinolytic activity of blood.

Alprostadil affects the metabolism and increases utilization of glucose and oxygen, inhibits the release of free radicals and lysosomal enzymes from granulocytes and macrophages, stimulates protein synthesis, has a favorable effect on lipid metabolism (inhibiting the synthesis of cholesterol and reducing the concentration of LDL), inhibits the proliferation of smooth muscle cells.

Alprostadil has a stimulating effect on smooth muscles of intestines, bladder, uterus, suppresses gastric acid secretion.

When Alprostadil introduced intracavernous it blocks alpha-1-adrenergic receptors in tissues of the penis, has a relaxing effect on smooth muscles of cavernous bodies, helps to increase blood flow and improve microcirculation. Expansion of the cavernous arteries and blood vessels of trabecular smooth muscle corpus cavernosum leads to a rapid increase in blood flow and dilation of lacunar spaces in the cavernous bodies. Venous outflow through the blood vessels located under the tunica albuginea is limited and that stimulates the development of erectile dysfunction ("corporal veno occlusive mechanism"). Alprostadil begins to act in 5-10 minutes, the duration of action is 1-3 hours.

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of Alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of Alprostadil increase pulmonary or systemic blood flow.

Alprostadil injection is used to treat erectile dysfunction (impotence) in men.

Intravenous Maintenance of patency of ductus arteriosus in neonates with congenital heart disease

Child: 0.05-0.1 mcg/kg/minute by continuous IV infusion, may increase to 0.4 mg/kg/minute. To be injected into a large vein, or alternatively through an umbilical artery catheter placed at the ductal opening. Reduce to the lowest dose necessary to maintain response as soon as possible. Intracavernosal Erectile dysfunction

Adult: Initially, 2.5 mcg, then 5 mcg, further increments may be made in steps of 5-10 mcg depending on erectile response. Once the optimal dose is determined, it should not be given >1 time/day or 3 times/wk. Usual

Maintenance: 5-20 mcg/day. Max: 60 mcg/day. For neurogenic origin (e.g. spinal cord injury): Initially, 1.25 mcg, may increase to 2.5 mcg, then 5 mcg (if needed). Intracavernosal Diagnosis of erectile dysfunction

Adult: 5-20 mcg. A dose of 500 mcg may also be administered trans-urethrally. Urethral Erectile dysfunction

Adult: Initially 250 mcg, may increase to 500 or 1000 mcg or reduce to 125 mcg depending on erectile response. The optimal dose should not be given >2 times/day or 7 times/wk.

Intravenous Maintenance of patency of ductus arteriosus in neonates with congenital heart disease

Child: 0.05-0.1 mcg/kg/minute by continuous IV infusion, may increase to 0.4 mg/kg/minute. To be injected into a large vein, or alternatively through an umbilical artery catheter placed at the ductal opening. Reduce to the lowest dose necessary to maintain response as soon as possible. Urethral Erectile dysfunction

Adult: Initially 250 mcg, may increase to 500 or 1000 mcg or reduce to 125 mcg depending on erectile response. The optimal dose should not be given >2 times/day or 7 times/wk. Intracavernosal Erectile dysfunction

Adult: Initially, 2.5 mcg, then 5 mcg, further increments may be made in steps of 5-10 mcg depending on erectile response. Once the optimal dose is determined, it should not be given >1 time/day or 3 times/wk. Usual

Maintenance: 5-20 mcg/day. Max: 60 mcg/day. For neurogenic origin (e.g. spinal cord injury): Initially, 1.25 mcg, may increase to 2.5 mcg, then 5 mcg (if needed). Intracavernosal Diagnosis of erectile dysfunction

Adult: 5-20 mcg. A dose of 500 mcg may also be administered trans-urethrally.

Indications:

Adult: Intracavernosal Erectile dysfunction Initial: 2.5 mcg, may increase gradually until an effective dose is achieved. Once the optimal dose is determined, it should not be given >1 time/day or 3 times/wk. Usual

Maintenance: 5-20 mcg/day. Max: 60 mcg/day. Diagnosis of erectile dysfunction 5-20 mcg. Urethral Erectile dysfunction Initial: 250 mcg, may increase to 500 or 1000 mcg or reduce to 125 mcg according to response. Not to be given >2 times/day or 7 times/wk.

When Alprostadil Sicor Pharmaceuticals introduced intracavernous it blocks alpha-1-adrenergic receptors in tissues of the penis, has a relaxing effect on smooth muscles of cavernous bodies, helps to increase blood flow and improve microcirculation. Expansion of the cavernous arteries and blood vessels of trabecular smooth muscle corpus cavernosum leads to a rapid increase in blood flow and dilation of lacunar spaces in the cavernous bodies. Venous outflow through the blood vessels located under the tunica albuginea is limited and that stimulates the development of erectile dysfunction ("corporal veno occlusive mechanism"). Alprostadil Sicor Pharmaceuticals begins to act in 5-10 minutes, the duration of action is 1-3 hours.

When Alprostadil Bedford Laboratories introduced intracavernous it blocks alpha-1-adrenergic receptors in tissues of the penis, has a relaxing effect on smooth muscles of cavernous bodies, helps to increase blood flow and improve microcirculation. Expansion of the cavernous arteries and blood vessels of trabecular smooth muscle corpus cavernosum leads to a rapid increase in blood flow and dilation of lacunar spaces in the cavernous bodies. Venous outflow through the blood vessels located under the tunica albuginea is limited and that stimulates the development of erectile dysfunction ("corporal veno occlusive mechanism"). Alprostadil Bedford Laboratories begins to act in 5-10 minutes, the duration of action is 1-3 hours.

When Alprostadil Valeo Pharma introduced intracavernous it blocks alpha-1-adrenergic receptors in tissues of the penis, has a relaxing effect on smooth muscles of cavernous bodies, helps to increase blood flow and improve microcirculation. Expansion of the cavernous arteries and blood vessels of trabecular smooth muscle corpus cavernosum leads to a rapid increase in blood flow and dilation of lacunar spaces in the cavernous bodies. Venous outflow through the blood vessels located under the tunica albuginea is limited and that stimulates the development of erectile dysfunction ("corporal veno occlusive mechanism"). Alprostadil Valeo Pharma begins to act in 5-10 minutes, the duration of action is 1-3 hours.

Active ingredients: Alprostadil
Unit description, dosagePrice, USD
Injectable; Injection; Alprostadil 0.5 mg / ml
Alprostadil powder$ 5049.00
Edex Cartridge 6 Pack 40 mcg Kit Box$ 412.40
Caverject 6 40 mcg Solution Box$ 341.78
Edex 6 Pack 20 mcg Kit Box$ 301.00
Caverject 6 20 mcg Solution, 1 Box Contains 6 Vials Box$ 272.05
Prostin Vr 500 mcg/ml$ 266.72
Edex Cartridge 6 Pack 10 mcg Kit Box$ 233.65
Edex Cartridge 2 Pack 40 mcg Kit Box$ 135.23
Edex 40 mcg cartridge kit$ 132.18
Prostin vr 500 mcg/ml ampul$ 108.00
Edex 2 Pack 20 mcg Kit Box$ 97.47
Edex 20 mcg cartridge kit$ 96.47
Edex Cartridge 2 Pack 10 mcg Kit Box$ 77.22
Edex 10 mcg cartridge kit$ 74.88
Alprostadil 500 mcg/ml vial$ 66.00
Caverject Impulse 1 Box = 2 Blister Trays, 20 mcg$ 47.77
Caverject impulse 20 mcg kit$ 46.66
Caverject Impulse 1 Box = 2 Blister Trays, 10 mcg$ 37.51
Muse 1000 mcg Pellets$ 36.97
Caverject impulse 10 mcg kit$ 36.23
Muse 1000 mcg urethral suppository$ 35.54
Muse 500 mcg Pellets$ 34.23
Muse 500 mcg urethral suppository$ 32.92
Muse 250 mcg Pellets$ 31.99
Muse 250 mcg urethral suppository$ 30.76
Muse 125 mcg Pellets$ 30.56
Muse 125 mcg urethral suppository$ 29.39

List of alprostadil brand and generic drugs

Alprestil (Hungary)
Alprostadil "Pint" (Romania)
Alprostadil Gray (Argentina)
Alprostadil Medisa (Japan)
Alprostadil Panpharma (France)
Alprostadil Pharmacia (Spain)
Alprostadil Prostoglandin E1
Alprostadil Richet (Argentina)
Alprostadil Sawai (Japan)
Alprostan (Czech Republic, Russian Federation, Slovakia)
Injectable; Subcutaneous; Alprostadil 0.1 mg
Injectable; Injection; Alprostadil 0.1 mg
Alprostapint (Austria, Bulgaria, Israel, Poland, Slovakia)
Injectable; IV (Infusion); Alprostadil 0.5 mg / ml
Injectable; Infusion; Alprostadil 0.5 mg / ml
Alprostar (Italy)
Alprostin (Slovenia)
Altesil (Japan)
Alyprost (Japan)
Apilcav
Apistandin (Japan)
Aplicav (Brazil)
Befar
Cream; Topical; Alprostadil 0.4%
Bioglandin (India)
Bioglandin 500mcg INJ / 1ml
500 mcg x 1's
Bolesi (China)
Bondil (Norway, Sweden)
Cardiobron (Argentina)
Caverject (Australia, Austria, Bahrain, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Czech Republic, El Salvador, Estonia, Finland, France, Germany, Greece, Guatemala, Honduras, Hong Kong, Hungary, Iceland, Ireland, Israel, Italy, Latvia, Malaysia, New Zealand, Nicaragua, Oman, Panama, Peru, Poland, Portugal, Romania, Russian Federation, Singapore, Slovenia, South Africa, Spain, Sweden, Switzerland, United Kingdom, United States, Venezuela)
Injectable; Injection; Alprostadil 10 mcg / ml
Injectable; Injection; Alprostadil 20 mcg / ml
Injectable; Injection; Alprostadil 40 mcg / ml
Injectable; Injection; Alprostadil 5 mcg / ml
Caverject 20 mcg x 1's
Caverject (vial) 10 mcg x 1's
Caverject (vial) 20 mcg x 1's
Caverject 10 mcg x 1 loï vaø bôm tieâm chöùa 1 mL nöôùc pha tieâm vaø kim
Caverject 10 mcg x 1 loï vaø bôm tieâm chöùa 1 mL nöôùc pha tieâm vaø 2 kim
Caverject 20 mcg x 1 loï vaø bôm tieâm chöùa 1 mL nöôùc pha tieâm vaø 2 kim
Caverject 20 mcg x 1 loï vaø bôm tieâm chöùa 1 mL nöôùc pha tieâm vaø kim
Caverject DC
Injectable; Injection; Alprostadil 10 mcg
Injectable; Injection; Alprostadil 20 mcg
Caverject Dual (Denmark, Norway, Sweden)
Caverject Dual Chamber (Hongkong)
Injectable; Injection; Alprostadil 10 mcg
Injectable; Injection; Alprostadil 20 mcg

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