Anablock - Anablock lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.
Anablock is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).
Anablock may also be used for purposes not listed in this medication guide.
Pharmacology: A selective nonsteroidal aromatase inhibitor. It lowers serum estradiol concentrations.
Indication: Advanced breast cancer in postmenopausal women with progression following tamoxifen therapy; first-line treatment of postmenopausal women with hormone receptor–positive or hormone receptor unknown locally advanced or metastatic breast cancer; for adjuvant treatment of postmenopausal women with hormone receptor–positive early breast cancer.
Anablock is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of advanced breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In post-menopausal women, the principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol. Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anablock is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
Anablock is used to treat breast cancer in women who have reached menopause (menstrual cycle has stopped). Anablock lowers the level of a female hormone called oestrogen. This helps to slow down the growth of breast cancer cells because breast cancer cells need oestrogen to grow. It can be used on its own or together with chemotherapy, radiotherapy or surgery to treat breast cancer. Anablock may also be used for other purposes, such as to prevent breast cancer in women who are at a high risk of developing breast cancer.
Oral Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer
Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr.
Adult: PO Adjuvant treatment in early breast cancer ; Advanced or locally advanced breast cancer In postmenopausal women: 1 mg/day.
Oral Advanced breast cancer in postmenopausal women, Adjuvant treatment in early breast cancer in postmenopausal women
Adult: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr.