Arilex FT - Pharmacology: Partial agonist at dopamine D receptor.
Treatment of schizophrenia in adults and adolescents 13 to 17 yr of age; acute and maintenance treatment of manic and mixed episodes associated with bipolar I disorder in adults and children 10 to 17 yr of age; adjunctive therapy to either lithium or valproate for the acute treatment of manic and mixed episodes associated with bipolar I disorder in adults and children 10 to 17 yr of age; adjunctive therapy to antidepressants for the acute treatment of major depressive disorder in adults; treatment of irritability associated with autistic disorder in children 6 to 17 yr of age.
Treatment of agitation associated with schizophrenia or bipolar disorder, manic or mixed, in adults.
Cocaine dependence; restless leg syndrome (oral).
Arilex FT is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Arilex FT is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Arilex FT acts as an antagonist at other receptors, but with lower potency. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of Aripiprazole. Aripiprazole's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Aripiprazole's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.
Arilex FT is used to treat schizophrenia. It helps to relieve symptoms common in schizophrenia, such as distorted thinking and emotional instability. Arilex FT is also used to treat other mood or psychiatric conditions such as paranoia, bipolar disorder (mania and hypomania), depression and irritability that are linked to autism.
Arilex FT Intramuscular injection is used to treat schizophrenia and bipolar disorder (manic-depressive illness). It helps to quickly relieve symptoms common in schizophrenia and bipolar disorder, such as agitation, distress, distorted thinking and emotional instability.
Adult: Initial dose: 10-15 mg once daily. Usual maintenance dose: 15 mg once daily. Adjust dose at intervals of at least 2 wk. Max dose: 30 mg once daily. Oral Acute manic episodes of bipolar disorder
Adult: 30 mg once daily, decreased to 15 mg once daily based on tolerability.
Adult: PO Schizophrenia Initial: 10-15 mg once daily.
Maintenance: 15 mg once daily. Max: 30 mg once daily. Bipolar mania 30 mg once daily. May reduce to 15 mg once daily according to tolerability.