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Arthene

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Arthene uses and description

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Arthene - Arthene reverses the effects of opioid (OH-pee-oid) medications, also called narcotics. Opioid effects include drowsiness, low blood pressure, and slowed breathing.

Arthene is used to treat a narcotic overdose or other situation in which opioid side effects may be harmful.

Arthene may also be used for purposes other than those listed in this medication guide.

Indications:

Adult: IV/IM/SC Opioid overdosage Non-opioid dependent patients: Initial: 0.5 mg/70 kg; followed by a 2nd dose of 1 mg/70 kg after 2-5 min if needed. If no clinical response observed after total dose of 1.5 mg/kg, additional doses are unlikely to provide therapeutic effect. Opioid-dependent patients: Initial: A challenge dose of 0.1 mg/70 kg; if no withdrawal symptoms are observed in 2 min, follow the incremental dosing recommended. Reversal of central depression from opioid use during surgery Initial: 0.25 mcg/kg; followed by 0.25 mcg/kg incremental doses at 2-5 min intervals until desired opioid reversal is achieved. Cumulative total dose above 1 mcg/kg does not provide additional therapeutic effect.

Parenteral Opioid overdosage

Adult: IV route preferred; may administer via IM or SC should IV access be lost or not readily attainable. Non-opioid dependent patients: Initial: 0.5 mg/70 kg; followed by a 2nd dose of 1 mg/70 kg after 2-5 min if needed. If no clinical response observed after total dose of 1.5 mg/kg, additional doses are unlikely to provide therapeutic effect. Opioid-dependent patients: Initial: A challenge dose of 0.1 mg/70 kg; if no withdrawal symptoms are observed in 2 min, may be followed by the incremental dosing recommended. Parenteral Reversal of central depression from opioid use during surgery

Adult: Titrate dose to reverse undesired effects of opioids without inducing a complete reversal and acute pain. Initial: 0.25 mcg/kg administered via IV/IM/SC route; followed by 0.25 mcg/kg incremental doses at 2-5 min intervals until desired opioid reversal is achieved. Cumulative total dose above 1 mcg/kg does not provide additional therapeutic effect. Patients with increased CV risks: Dilute Arthene with normal saline or sterile water for inj to 1:1 ratio; initiate and titrate at 0.1 mcg/kg every 2-5 min intervals. Renal impairment: Administer incremental doses slowly (over 60 seconds) to minimise HTN and dizziness. Incompatibility: Compatible with 0.9% sodium chloride inj. Incompatibility: Compatible with 0.9% sodium chloride inj.

Active ingredients: Nalmefene
Unit description, dosagePrice, USD

List of arthene brand and generic drugs

Alcofene
Cervene
Cessal
Incystene
Lemeng (China)
Nalmefene (United States)
Nocarex
Revex (United States)
Injectable; Injection; Nalmefene Hydrochloride0.1 mg / ml
Injectable; Injection; Nalmefene Hydrochloride 1 mg / ml
1 milliliter in 1 ampule
2 milliliter in 1 ampule
Shuna (China)
Soberal
 
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