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Atrosite

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Atrosite uses and description

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Atrosite - Pharmacology: Inhibits action of acetylcholine or other cholinergic stimuli at postganglionic cholinergic receptors, including smooth muscles, secretory glands, and CNS sites.

Indication: Administration prior to anesthesia to reduce or prevent secretions of respiratory tract; to control rhinorrhea; treatment of parkinsonism; restoration of cardiac rate and arterial pressure in some situations; treatment of peptic ulcers; management of hypersecretion, irritation, or inflammation of stomach, intestines, or pancreas; treatment of diarrhea; relief of infant colic; management of spasms of bile tract; treatment of hypertonicity of small intestine and uterus; management of hypermotility of colon; prevention of spasm of pylorus, biliary tree, ureters, and bronchi; treatment of frequent urination and bed-wetting; therapy for certain bradycardias and heart blocks; treatment of closed head injury with acetylcholine release; reduction of laughing and crying associated with brain lesions; treatment of alcohol withdrawal symptoms; relief of motion sickness. Antidote for CV collapse in certain overdoses or poisonings (eg, organophosphorous nerve agents having cholinesterase activity, organophosphorous or carbamate insecticides, muscarinic symptoms of insecticide or nerve agent poisonings). Short-term treatment and prevention of bronchospasm associated with chronic bronchial asthma, bronchitis, and COPD.

Ophthalmic

Production of cycloplegia and mydriasis.

Atrosite produces many effects in the body, including relief from spasms of the gastrointestinal tract (stomach and intestines), the bladder, and the biliary tract. This is helpful in controlling conditions such as colitis, spastic bladder, diverticulitis, infant colic, renal and biliary colic, peptic ulcer, and irritable bowel syndrome.

Atrosite also reduces the secretions of many organs, thereby helping to control conditions such as excessive stomach acid production and excessive secretion from the pancreas; to reduce secretions of the nose, lungs, salivary glands, and stomach before surgery; and to help dry up excessive mucus production associated with diseases, infections, and allergies.

Atrosite is used to treat the rigidity, tremor, excessive salivation, and sweating caused by Parkinson's disease.

Atrosite also has effects on the heart. It is used during surgery to maintain proper heart function, during emergencies involving the heart, and to treat certain heart disorders.

Atrosite is used to control laughing and crying episodes that are caused by brain tumors.

Atrosite also has effect on the eyes and is available in an ophthalmic (eye) formulation.

Atrosite may also be used for purposes other than those listed in this medication guide.

Atrosite, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atrosite is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of Atrosite abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atrosite may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atrosite in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, Atrosite does not exert a striking or uniform effect on blood vessels or blood pressure.

Parenteral Premedication in balanced anaesthesia

Adult: 300-600 mcg IM/SC 30-60 minutes before anaesthesia. Alternatively, 300-600 mcg IV immediately before induction of anaesthesia.

Child: >20 kg: 300-600 mcg; 12-16 kg: 300 mcg; 7-9 kg: 200 mcg; >3 kg: 100 mcg. Doses to be given via IM/SC admin 30-60 minutes before anaesthesia. Parenteral Organophosphorus poisoning

Adult: 2 mg IV/IM, every 10-30 minutes until muscarinic effects disappear or Atrosite toxicity appears. In severe cases, dose can be given as often as every 5 minutes. In moderate to severe poisoning, a state of atropinisation is maintained for at least 2 days and continued for as long as symptoms are present.

Child: 20 mcg/kg given every 5-10 minutes. Parenteral Poisoning or overdosage with compounds having muscarinic actions

Adult: 0.6-1 mg IV/IM/SC, repeated every 2 hr. Intravenous Bradycardia

Adult: 500 mcg every 3-5 minutes. Total: 3 mg. Max

Dosage: 0.04 mg/kg body weight. Ophthalmic Inflammatory eye disorders

Adult: Instill 1-2 drops of a 0.5-1% solution up to 4 times daily.

Child: As sulfate: Instill 1-2 drops of a 0.5% soln (or 1 drop of a 1% solution) up to tid. Ophthalmic Eye refraction

Adult: Instill 1 drop of a 1% solution bid for 1-2 days before the procedure, or on a single occasion 1 hr before the procedure.

Child: As sulfate: Instill 1 or 2 drops of a 0.5% soln (or 1 drop of a 1% solution) bid for 1-3 days before the procedure, with a further dose given 1 hr before the procedure. Incompatibility: Incompatible with hydroxybenzoate preservatives.

Indications:

Adult: IV Bradycardia 500 mcg every 3-5 mins. Total: 3 mg. IV/IM Organophosphorus poisoning 2 mg every 10-30 mins until muscarinic effects disappear or Atrosite toxicity appears. IM/SC Premed in anesth 300-600 mcg 30-60 mins before anesth. IV/IM/SC Poisoning or overdosage w/ compd having muscarinic actions 0.6-1 mg, repeat 2 hrly. Ophth Inflammatory eye disorders As 0.5-1% soln: 1-2 drops 4 times/day. Eye refraction As 1% soln: 1 drop twice daily for 1-2 days before procedure.

Intravenous Bradycardia

Adult: 500 mcg every 3-5 minutes. Total: 3 mg. Max

Dosage: 0.04 mg/kg body weight. Parenteral Premedication in balanced anaesthesia

Adult: 300-600 mcg IM/SC 30-60 minutes before anaesthesia. Alternatively, 300-600 mcg IV immediately before induction of anaesthesia.

Child: >20 kg: 300-600 mcg; 12-16 kg: 300 mcg; 7-9 kg: 200 mcg; >3 kg: 100 mcg. Doses to be given via IM/SC admin 30-60 minutes before anaesthesia. Parenteral Organophosphorus poisoning

Adult: 2 mg IV/IM, every 10-30 minutes until muscarinic effects disappear or Atrosite toxicity appears. In severe cases, dose can be given as often as every 5 minutes. In moderate to severe poisoning, a state of atropinisation is maintained for at least 2 days and continued for as long as symptoms are present.

Child: 20 mcg/kg given every 5-10 minutes. Parenteral Overdosage with other compounds having muscarinic actions

Adult: 0.6-1 mg IV/IM/SC, repeated every 2 hr. Ophthalmic Inflammatory eye disorders e.g. uveitis or iritis

Adult: Instill 1-2 drops of a 0.5-1% solution up to 4 times daily.

Child: As sulfate: Instill 1-2 drops of a 0.5% soln (or 1 drop of a 1% solution) up to tid. Ophthalmic Eye refraction

Adult: Instill 1 drop of a 1% solution bid for 1-2 days before the procedure, or on a single occasion 1 hr before the procedure.

Child: As sulfate: Instill 1 or 2 drops of a 0.5% soln (or 1 drop of a 1% solution) bid for 1-3 days before the procedure, with a further dose given 1 hr before the procedure. Incompatibility: Incompatible with hydroxybenzoate preservatives.

Active ingredients: Atropine
Unit description, dosagePrice, USD

List of atrosite brand and generic drugs

Atroren-P (Thailand)
1 % w/v x 5ml$ 0.20
Atrosol (Turkey)
Atrosol 10 mg/1 mL x 1's
Atrospan (Israel)
Solution; Ophthalmic; Atropine Sulfate 1%
Atrosulf
Atrosun (India)
Atrosun 1% EYE-DPS / 3ml$ 0.24
1 % x 3ml$ 0.24
Atrover
Atrover 0.6mg INJ / 1ml$ 0.15
Bell Pino Atrin
Bell Pino Atrin Eye 5 ml Drop$ 0.37
Bell Pino Atrin Eye 3 gm Ointment$ 0.28
Bell Pino-Atrin (India)
Bellafit (Switzerland)
Bellafit N
Drops; Ophthalmic; Atropine Sulfate 0.005%
Bellapan (Poland)
Borotropin
Chibro-Atropine
Colircusi Atropina (Portugal, Spain)
Colircusi Atropine (Taiwan)
Colircusi Atropine 0.5 % x 10 mL
Colirio Ocul Atropina (Spain)
Deco-AT (India)
Deco-AT Atropine 1 % w/v,Dexamethasone 0.01 % w/v,Chloramphenicol 0.5 % w/v. EYE-DPS / 10ml$ 0.69
10ml$ 0.69
Di Shan (China)
Dioptic's Atropine
Solution; Ophthalmic; Atropine Sulfate 1%
Dolospam Lch (Peru)
Dysurgal (Germany)
Dragee; Oral; Atropine Sulfate; Ephedrine Hydrochloride; Strychnine Nitrate
Elon-Plus (United States)
Endotropina (Argentina)
Eyesules
Homapin
Homeopathic Medicine S No. 391
Drops; Oral; Atropine 30 c / ml
I-Tropine
Ilium Atropine (Australia)
Injectio Atropini Sulfatis (Taiwan)
International Apex Atropine Sulfate (Philippines)
Isopto Atropina (Argentina, Peru)
Isopto Atropine (Belgium, Botswana, Canada, Eritrea, Ethiopia, Ghana, Kenya, Luxembourg, Malawi, Namibia, Nigeria, Oman, Singapore, South Africa, Sri Lanka, Sweden, Tanzania, Uganda, United Kingdom, United States, Zambia, Zimbabwe)
Solution; Ophthalmic; Atropine Sulfate 1%
Isopto Atropine 10 mg/1 mL x 5 mL$ 6.08
Isopto Atropine 0.5 % x 5 mL
Isopto Atropine 1 % x 5 mL
Isopto-Atropin (Iceland, Sweden)
Isopto-atropine
Itropin (Bangladesh)
Klonatropina (Peru)

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