Azium - Azium is a glucocorticosteroid. This medication Inhibits the function of leukocytes and tissue macrophages. Azium restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Azium decreases capillary permeability caused by histamine release. This medicine inhibits the activity of fibroblasts and collagen formation.
Azium inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.
With direct application to the vessels this drug has a vasoconstrictor effect.
Azium has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats.
In high doses Azium may increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness.
With systemic use of therapeutic activity of Azium is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.
For external and local use of therapeutic activity of Azium is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.
Azium and its derivatives, Azium sodium phosphate and Azium acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, Azium is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.
Indication: Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.