B - LONG - Pyridoxine is vitamin B6. Vitamins are naturally occurring substances necessary for many processes in the body. Pyridoxine is important in the breakdown of protein, fats, and carbohydrates from foods into products needed by the body.
Pyridoxine is used to treat or prevent B - LONG deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is used to treat some types of seizure in babies.
Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.
Pyridoxine may also be used for purposes not listed in this medication guide.
B - LONG (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of B - LONG deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). B - LONG has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that B - LONG deficiency affects cellular and humoral responses of the immune system. B - LONG deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Indication: For the treatment of B - LONG deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pernicious anaemia, peripheral neuritis especially diabetic and alcoholic polyneuritis, trigeminal neuritis, vomiting of pregnancy, vitamin B complex deficiency, anorexia, agranulocytosis, radiation sickness, coeliac and idiopathic, steatorrhoea which are usually accompanied by malabsorption of vitamin B 12 and during administration of broad-spectrum antibiotics.