BREATHEZY - BREATHEZY is used to treat asthma. When taken regularly, BREATHEZY helps to prevent the chest tightness, wheezing and breathlessness that is common in asthma. It may also be used to prevent breathlessness that is triggered by exercise or physical exertion. BREATHEZY is meant to be taken long-term. It is not meant for fast relief during acute asthma attacks.
Montelukast (trade name Singulair)(Openair in Pakistan) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast is a CysLT1 antagonist; that is it blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.
Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as theophylline.
Another leukotriene receptor antagonist is zafirlukast (Accolate), taken twice daily. Zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.
The Mont in Montelukast stands for Montreal, the place where Merck developed the drug.
Indications: Chronic asthma.
Seasonal allergic rhinitis.
Perennial allergic rhinitis.
Prophylaxis of exercise-induced asthma.