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Biseptol

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Biseptol uses and description

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Biseptol - Synthetic antimicrobial drug with broad spectrum bactericidal action. Biseptol has a bacteriostatic action, which is associated with inhibition of recycling process of PABA and a violation dihydrofolic acid\'s synthesis in bacterial cells. Trimethoprim inhibits the enzyme that is involved in the metabolism of folic acid converting dihydrofolate to tetrahydrofolate. Thus it is blocked two successive stages of the biosynthesis of purines and therefore nucleic acids that are essential for growth and reproduction of bacteria. High concentrations created in the tissues of the lung, kidney, prostate, cerebrospinal fluid, bile, bones.

Co-trimoxazole is active against gram-positive bacteria: Staphylococcus spp. (including strains of penicillinase producing), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae; gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella spp., Yersinia spp., Vibrio cholerae, Haemophilus influenzae; anaerobic asporogenous bacteria - Bacteroides spp. Co-trimoxazole is active also against Chlamydia spp.

Pseudomonas aeruginosa, Treponema spp., Mycoplasma spp., Mycobacterium tuberculosis and also viruses and fungi are resistant to co-trimoxazole.

Co-trimoxazole exhibits a synergistic antibacterial effect when compared to each of its components administered singly. This is because trimethoprim and Biseptol inhibit successive steps in the folate synthesis pathway.

Biseptol acts as a false-substrate inhibitor of dihydropteroate synthetase. Sulfonamides such as Biseptol are analogues of p-aminobenzoic acid (PABA) and are competitive inhibitors of the enzyme; inhibiting the production of dihydropteroic acid.

Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid.

Indications:

  • tell your doctor and pharmacist if you are allergic to co-trimoxazole, diuretics (\'water pills\'), oral diabetes medications, any sulfa drug, or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially methotrexate, phenytoin (Dilantin), warfarin (Coumadin), and vitamins.
  • tell your doctor if you have or have ever had liver or kidney disease, asthma, severe allergies, or glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (an inherited blood disease).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking co-trimoxazole, call your doctor.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Co-trimoxazole may make your skin sensitive to sunlight.

  • Indications: bacterial infections, pneumocystis pneumonia

    Indications: bacterial infections, pneumocystis pneumonia, toxoplasmosis

    Treatment of enteritis; treatment of Pneumocystis carinii pneumonia; treatment of severe or complicated UTIs caused by susceptible strains of bacteria.-Treatment of acute otitis media and acute exacerbations of chronic bronchitis; treatment of traveler’s diarrhea; treatment and prophylaxis of P. carinii pneumonia; Shigella enteritis; UTIs caused by susceptible strains of bacteria.-Treatment of cholera, salmonella-type infections, and nocardiosis; prevention of recurrent UTIs in women; prophylaxis of bacterial infections in susceptible patients; treatment of acute and chronic bacterial prostatitis; treatment of skin and soft-tissue infections caused by Staphylococcus aureus.

    Active ingredients: Sulfamethoxazole/Trimethoprim
    Unit description, dosagePrice, USD
    Injectable; Injection; Sulfamethoxazole 80 mg; Trimethoprim 16 mg / ml
    Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml
    Tablet; Oral; Sulfamethoxazole 100 mg; Trimethoprim 20 mg
    Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
    Biseptol 120mg - 20 Tablets$ 5.20
    Biseptol 240mg/5ml-80ml - 1 Suspension$ 14.60
    Biseptol 480 mg - 20 Tablets$ 8.40
    Biseptol 480mg/5ml - 10 Vial$ 36.40
    Biseptol 80ml - 1 Suspension$ 18.80
    Biseptrim 480 mg - 20 Tablets$ 8.40
    Tablets; Oral; Sulfamethoxazole 100 mg; Trimethoprim 20 mg
    Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg

    List of biseptol brand and generic drugs

    Biprim (Pakistan)
    Biseptol 480 mg (Vietnam)
    Biseptol 480 mg 1 Blister x 20 Tablet
    Biseptol sus. (Vietnam)
    Biseptol sus. 1 chai 80 mL
    Biseptrin (Romania)
    Bismoral (Czech Republic, Slovakia)
    Bitrim (Bangladesh)
    Boschtrim (Pakistan)
    Cadaprim-R (Ethiopia)
    Cadiprim (Ethiopia)
    5ml$ 0.28
    Cadiprim Trimethoprim 1 mg, Polymyxin Bsulphate 10000 IU, Polyvinylalcohol 0.25 %. EYE/EAR DPS / 5ml$ 0.28
    Cadiprim E/E Drop$ 0.28
    Canibioprim (France)
    Casicot (South Africa)
    Chevi-Trim (Austria)
    Ciplin (India)
    CIPLIN Capsule/ Tablet / 800mg - 160mg (10 units)$ 0.20
    CIPLIN Capsule/ Tablet / 400mg - 80mg (10 units)$ 0.12
    CIPLIN Liquid / 200mg - 40mg per 5ml (50ml units)$ 0.18
    Ciplin Sulfamethooxazole400mg,Trimethoprim 80mg TAB / 10$ 0.11
    Ciplin Sulfamethooxazole200mg,Trimethoprim 40mg/5ml SUSP / 50ml$ 0.18
    50ml$ 0.18
    10's$ 0.11
    Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml
    Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
    Ciplin 400+80 Tablet$ 0.01
    Ciplin 50 ml Syrup$ 0.02
    Ciplin Sulfamethooxazole400mg, Trimethoprim 80mg TAB / 10$ 0.11
    Ciplin Sulfamethooxazole200mg, Trimethoprim 40mg/5ml SUSP / 50ml$ 0.18
    Ciplin DS
    Ciplin DS Sulfamethooxazole800mg,Trimethoprim 160mg TAB / 10$ 0.21
    Ciplin DS 800+160 Tablet$ 0.02
    Co-Sultrin (Venezuela)
    Co-Trim (Romania)
    Co-Trimo (Taiwan)
    Co-Trimo
    Co-Trimox F (Vietnam)
    Co-Trimox F 1 Blister x 10 Tablet
    Co-Trimoxazol (Georgia, Lithuania, Netherlands, United Kingdom)
    Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
    Tablet; Oral; Sulfamethoxazole 100 mg; Trimethoprim 20 mg
    Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml
    Tablet; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
    Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
    Tablets; Oral; Sulfamethoxazole 100 mg; Trimethoprim 20 mg
    Tablets; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
    Co-Trimoxazol A (Netherlands)
    Co-Trimoxazol Actavis (Netherlands)

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