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CADUET®

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CADUET® uses and description

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CADUET® - CADUET (amlodipine and atorvastatin) is indicated in patients for whom treatment withboth amlodipine and atorvastatin is appropriate. Amlodipine:Hypertension: Amlodipine is indicated for the treatment of hypertension. It may beused alone or in combination with other antihypertensive agents;Coronary Artery Disease (CAD)Chronic Stable Angina: Amlodipine is indicated for the treatment of chronic stableangina. Amlodipine may be used alone or in combination with other antianginal orantihypertensive agents;Vasospastic Angina (Prinzmetal’s or Variant Angina): Amlodipine is indicated forthe treatment of confirmed or suspected vasospastic angina. Amlodipine may be usedas monotherapy or in combination with other antianginal drugs. Angiographically Documented CAD: In patients with recently documented CAD byangiography and without heart failure or an ejection fraction <40%, amlodipine isindicated to reduce the risk of hospitalization due to angina and to reduce the risk of acoronary revascularization procedure. Atorvastatin:Therapy with lipid-altering agents should be only one component of multiple risk factorintervention in individuals at significantly increased risk for atherosclerotic vasculardisease due to hypercholesterolemia. Drug therapy is recommended as an adjunct to dietwhen the response to a diet restricted in saturated fat and cholesterol and othernonpharmacologic measures alone has been inadequate. In patients with CHD or multiplerisk factors for CHD, the atorvastatin component of CADUET can be startedsimultaneously with diet restriction. Prevention of Cardiovascular Disease:In adult patients without clinically evident coronary heart disease, but with multiplerisk factors for coronary heart disease such as age, smoking, hypertension, low HDLC,or a family history of early coronary heart disease, atorvastatin is indicated to:Reduce the risk of myocardial infarction. Reduce the risk of stroke. Reduce the risk for revascularization procedures and angina. In patients with type 2 diabetes, and without clinically evident coronary heart disease,but with multiple risk factors for coronary heart disease such as retinopathy,albuminuria, smoking, or hypertension, LIPITOR is indicated to:Reduce the risk of myocardial infarction. Reduce the risk of stroke. In patients with clinically evident coronary heart disease, LIPITOR is indicated to:Reduce the risk of non-fatal myocardial infarction. Reduce the risk of fatal and non-fatal stroke. Reduce the risk for revascularization procedures. Reduce the risk of hospitalization for CHF.Reduce the risk of angina. Heterozygous Familial and Nonfamilial Hyperlipidemia: Atorvastatin is indicatedas an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels and toincrease HDL-C in patients with primary hypercholesterolemia (heterozygous familialand nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb).Elevated Serum TG Levels: Atorvastatin is indicated as an adjunct to diet for thetreatment of patients with elevated serum TG levels (Fredrickson Type IV).Primary Dysbetalipoproteinemia: Atorvastatin is indicated for the treatment ofpatients with primary dysbetalipoproteinemia (Fredrickson Type III) who do notrespond adequately to diet. Homozygous Familial Hypercholesterolemia: Atorvastatin is indicated to reducetotal-C and LDL-C in patients with homozygous familial hypercholesterolemia as anadjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatmentsare unavailable. Pediatric Patients: Atorvastatin is indicated as an adjunct to diet to reduce total-C,LDL-C, and apo B levels in boys and postmenarchal girls, 10 to 17 years of age, withheterozygous familial hypercholesterolemia if after an adequate trial of diet therapythe following findings are present:a. LDL-C remains -190 mg/dL orb. LDL-C remains - 160 mg/dL and: there is a positive family history of premature cardiovascular disease or two or more other CVD risk factors are present in the pediatric patients. The antidyslipidemic component of CADUET has not been studied in conditions where themajor lipoprotein abnormality is elevation of chylomicrons (Fredrickson Types I and V).
Active ingredients: amlodipine besylate/atorvastatin calcium
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