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Capecitabine

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Capecitabine uses and description

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Capecitabine - Pharmacology: Capecitabine is an oral systemic prodrug that is enzymatically converted to 5-fluorouracil (5-FU). Healthy and tumor cells metabolize 5-FU to 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites cause cell injury by 2 different mechanisms. First, they inhibit the formation of thymidine triphosphate, which is essential for the synthesis of DNA. Second, nuclear transcriptional enzymes can mistakenly incorporate FUTP during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis.

Indication: Treatment of resistant metastatic breast cancer alone or in combination with docetaxel; colorectal cancer.

Unlabeled Uses

Adjuvant treatment of pancreatic cancer.

Capecitabine is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body

Capecitabine is used to treat breast cancer and colon or rectum cancer that has spread to other parts of the body.

Capecitabine may also be used for other purposes not listed in this medication guide.

Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic breast cancer and colon cancer. It is an orally administered systemic prodrug that has little pharmacologic activity until it is converted to fluorouracil by enzymes that are expressed in higher concentrations in many tumors. Fluorouracil it then metabolized both normal and tumor cells to 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).

Capecitabine is used to treat cancer of the breast, colon or rectum. Capecitabine reduces the size of the tumour by stopping cancer cells from growing. It may be used on its own or together with other cancer medicines.

Oral Breast cancer

Adult: 1.25 g/m 2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m 2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer. CrCl (ml/min) Dosage Recommendation 51-80 No adjustment needed. 30-50 Reduce dose to 950 mg/m 2 bid when starting dose is 1.25 g/m 2 bid. No dose adjustment is needed when starting dose is 1 g/m 2. <30 Avoid use. Oral Colorectal cancer

Adult: 1.25 g/m 2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m 2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer. CrCl (ml/min) Dosage Recommendation 51-80 No adjustment needed. 30-50 Reduce dose to 950 mg/m 2 bid when starting dose is 1.25 g/m 2 bid. No dose adjustment is needed when starting dose is 1 g/m 2. <30 Avoid use. Oral Gastric cancer

Adult: Used in combination with a platinum-based compound, 1 g/m 2 bid for 14 days, followed by a 7-day rest period. 1 st dose is given on the evening of day 1 and the last dose on the morning of day 15. CrCl (ml/min) Dosage Recommendation 51-80 No adjustment needed. 30-50 Reduce dose to 950 mg/m 2 bid when starting dose is 1.25 g/m 2 bid. No dose adjustment is needed when starting dose is 1 g/m 2. <30 Avoid use.

Indications:

Adult: PO Colorectal cancer; Breast cancer 1.25 g/m 2 twice daily for 14 days followed by a 7-day rest period. Treatment duration for colorectal cancer: 6 mth. Gastric cancer W/ platinum-based compd: 1 g/m 2 twice daily for 14 days, followed by a 7-day rest period.

Active ingredients: Capecitabine
Unit description, dosagePrice, USD
Xeloda 500 mg tablet$ 28.97
Xeloda 150 mg tablet$ 8.69

List of capecitabine brand and generic drugs

Capecitabina Varifarma (Argentina)
Capecite (India)
Capecite 500mg TAB / 8$ 18.35
500 mg x 8's$ 18.35
Capectan (Argentina)
Capefas (Argentina)
Capegard
Capegard 500mg FC-TAB / 10
Capegard 500 mg Tablet$ 2.22
Capehope
Capehope 500mg TAB / 10$ 29.63
Capiibine (India)
Capiibine 150mg TAB / 10$ 15.56
Capiibine 500mg TAB / 10$ 31.50
Capiibine 500mg TAB / 30$ 94.50
150 mg x 10's$ 15.56
500 mg x 10's$ 31.50
500 mg x 30's$ 94.50
Capiibine 500 mg Tablet$ 3.00
Capiibine 150 mg Tablet$ 1.56
Capres
Capres 150 mg Tablet$ 1.56
Capres 500 mg Tablet$ 3.16
Capscare
Capscare 500 mg Tablet$ 7.13
Captabin (India)
Captabin 500mg TAB / 10$ 26.85
500 mg x 10's$ 26.85
Captabin 500 mg Tablet$ 2.69
Capxcel (India)
Capxcel 500mg TAB / 100$ 296.30
500 mg x 100's$ 296.30
Capxcel 500 mg Tablet$ 2.96
Categor (Argentina)
Catepen (Argentina)
CAXETA (India)
500 mg x 4's$ 10.78
Caxeta 500mg TAB / 4$ 10.78
Citabin (India)
Citabin 500mg TAB / 10
500 mg x 10's
Derebel (Argentina)
Naprocap (India)
Naprocap 500mg FILCOTAB / 10$ 27.78
500 mg x 10's$ 27.78
Naprocap 500 mg Tablet$ 2.78
Xabine (India)
Xabine 500mg TAB / 10$ 24.07
Xabine 500 mg Tablet$ 2.41
Xecap (India)
Xecap 500mg FC-TAB / 10$ 27.78
500 mg x 10's$ 27.78
Xecap 500 mg Tablet$ 2.78
Xelocel (India)
Xelocel 250mg FC- TAB / 10$ 27.41
250 mg x 10's$ 27.41

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