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Captopril-50

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Captopril-50 uses and description

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Captopril-50 - Used for: Treating high blood pressure or heart failure. It is also used to treat kidney problems caused by diabetes in certain patients. It is also used to improve survival and manage heart failure in certain patients after a heart attack. It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Captopril-50 is an angiotensin-converting enzyme (ACE) inhibitor. It works by helping to relax blood vessels. This helps to lower blood pressure.

Pharmacology: Competitively inhibits angiotensin I–converting enzyme, preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion. Results in decreased BP, potassium retention, and reduced sodium reabsorption.

Indication: Treatment of diabetic nephropathy (proteinuria more than 500 mg/day) in patients with type 1 insulin-dependent diabetes mellitus and retinopathy; treatment of CHF, usually in combination with diuretics and digitalis; treatment of hypertension; to improve survival following MI in clinically stable patients with left ventricular dysfunction manifested as an ejection fraction of 40% or less and to reduce the incidence of overt heart failure and subsequent hospitalizations for CHF in these patients.

Unlabeled Uses

Hypertensive emergencies/urgencies; pediatric hypertension; Raynaud phenomenon.

Captopril-50 is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Captopril-50 is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack.

Captopril-50 may also be used for purposes not listed in this medication guide.

Captopril-50, an ACE inhibitor, antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may sustain its effects by causing increased vasodilation and decreased blood pressure.

Captopril is a type of medicine called ACE inhibitors. Captopril works by blocking the angiotensin-converting enzyme. ACE is part of a reaction in the body that causes the blood vessels to constrict. By inhibiting this enzyme,blood vessels are relaxed and blood pressure is lowered.

Captopril-50 can improve the efficiency of the heart. This allows the heart not to work as hard and more blood can be pumped out to the rest of the body. These effects are helpful for a person with congestive heart failure.

Indications:

  • to control high blood pressure (hypertension)
  • to relieve symptoms of congestive heart failure
  • to improve survival and decrease the chances of developing symptoms of congestive heart failure following a heart attack
  • to treat diabetic nephropathy.

  • Captopril-50 helps to keep your blood pressure under control. Captopril-50 relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Captopril-50 may also be used to treat other conditions, for example, heart failure.

    Oral Hypertension

    Adult: Initially, 12.5 mg bid or 6.25 mg bid in combination with a diuretic, at bedtime to avoid precipitous fall in BP, gradually increased at 2-4-wk intervals according to response.

    Maintenance: 25-50 mg bid. Max: 50 mg tid.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses.

    Elderly: Initially, 6.25 mg bid. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Heart failure

    Adult: Initially, 6.25-12.5 mg bid-tid.

    Maintenance: 25 mg bid-tid. Max: 50 mg tid.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Post myocardial infarction

    Adult: May be started 3 days after MI. Initially, 6.25 mg/day increased after several wk to 150 mg daily in divided doses if tolerated. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Diabetic nephropathy

    Adult: Proteinuria >500 mg per 24 hr (in patients with Type 1 diabetes mellitus and retinopathy): 25 mg tid. May be taken with other anti-hypertensives if patient requires further lowering of BP.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily.

    High blood pressure (hypertension) in adults (alone or combination with other antihypertensive agents, especially thiazide-type diuretics). The blood pressure-lowering effects of Captopril-50 and thiazides are additive. Treatment of patients with heart failure who have not responded adequately to treatment with diuretics and digitalis. Treatment of myocardial infarction and diabetic nephropathy.

    Oral Hypertension

    Adult: Initially, 12.5 mg bid or 6.25 mg bid in combination with a diuretic, at bedtime to avoid precipitous fall in BP, gradually increased at 2-4-wk intervals according to response.

    Maintenance: 25-50 mg bid. Max: 50 mg tid.

    Elderly: Initially, 6.25 mg bid. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Heart failure

    Adult: Initially, 6.25-12.5 mg bid-tid.

    Maintenance: 25 mg bid-tid. Max: 50 mg tid. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Post myocardial infarction

    Adult: May be started 3 days after MI. Initially, 6.25 mg/day increased after several wk to 150 mg daily in divided doses if tolerated. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Hypertension in diabetic nephropathy

    Adult: Microalbuminuria >30 mg/day: 75-100 mg daily in divided doses. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily.

    Oral Hypertension

    Adult: Initially, 12.5 mg bid or 6.25 mg bid in combination with a diuretic, at bedtime to avoid precipitous fall in BP, gradually increased at 2-4-wk intervals according to response.

    Maintenance: 25-50 mg bid. Max: 50 mg tid.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses.

    Elderly: Initially, 6.25 mg bid. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Heart failure

    Adult: Initially, 6.25-12.5 mg bid-tid.

    Maintenance: 25 mg bid-tid. Max: 50 mg tid.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Post myocardial infarction

    Adult: May be started 3 days after MI. Initially, 6.25 mg/day increased after several wk to 150 mg daily in divided doses if tolerated. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Oral Diabetic nephropathy

    Adult: Proteinuria >500 mg per 24 hr (in patients with Type 1 diabetes mellitus and retinopathy): 25 mg tid. May be taken with other anti-hypertensives if patient requires further lowering of BP.

    Child: Neonate: Test dose: 10-50 mcg/kg (for neonates <37 wk postmenstrual age: 10 mcg/kg), monitor BP for 1-2 hr; if tolerated give 10-50 mcg/kg 2-3 times daily, increased if needed. Max: 2 mg/kg daily in divided doses (for neonates <37 wk postmenstrual age: 300 mcg/kg daily in divided doses). 1 mth-12 yr: Test dose: 100 mcg/kg (max: 6.25 mg), monitor BP for 1-2 hr; if tolerated give 100-300 mcg/kg 2-3 times daily, increased if needed. Max: 6 mg/kg daily in divided doses (for 1-12 mth: Max: 4 mg/kg daily in divided doses). 12-18 yr: Test dose: 100 mcg/kg or 6.25 mg, monitor BP for 1-2 hr; if tolerated give 12.5-25 mg 2-3 times daily, increased if needed. Max: 150 mg daily in divided doses. CrCl (ml/min) Dosage Recommendation 21-40 Initially, 25 mg daily. Max: 100 mg daily. 10-20 Initially, 12.5 mg daily. Max: 75 mg daily. <10 Initially, 6.25 mg daily. Max: 37.5 mg daily. Special Populations: Patients with severe renal impairment: CrCl <30 mL/min: Initially, 12.5 mg bid.

    Hypertension: this medicine is indicated for the treatment of hypertension. Heart Failure:this medicine is indicated for the treatment of chronic heart failure with reduction of systolic ventricular function, in combination with diuretics and when appropriate, digitalis and beta-blockers. Myocardial Infarction:-Short -term (4 weeks) treatment: this medicine is indicated in any clinically stable patients within the first 24 hours of an infarction.-Long term prevention of symptomatic heart failure: this medicine is indicated in clinically stable patients with asymptomatic left ventricular dysfunction (ejection fraction <40%).Type I Diabetic Nephropathy:this medicine is indicated for the treatment of macroproteinuric diabetic nephropathy in patients with type I diabetes. (See section 5.1, Pharmacodynamic properties).

    Indications: All grades of hypertension, CHF and Scleroderma crisis.

    Active ingredients: Captopril
    Unit description, dosagePrice, USD

    List of captopril-50 brand and generic drugs

    Captopril-1A Pharma (Germany)
    Captopril-AC (Romania)
    Captopril-EG (Belgium, France, Italy, Luxembourg)
    Captopril-Egis (Bulgaria, Lithuania)
    Captopril-Mepha (Portugal, Switzerland)
    Captopril-R (Japan)
    Captopril-Ratio (Luxembourg)
    Captopril-ratiopharm (Austria, France, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden)
    Captopril-ShuGuang Pharm (China)
    Captopril-Tchaikapharma (Bulgaria)
    Captoprilan (Dominican Republic)
    Captopron
    Captor (Ireland)
    Captor 25 mg x 100's
    Captoreal
    Captoril
    Captoruna (Japan)
    Captosen
    Captoser
    Captosif
    Captosina (Spain)
    Captosol (Switzerland)
    Tablet; Oral; Captopril 12.5 mg
    Tablet; Oral; Captopril 25 mg
    Tablet; Oral; Captopril 50 mg
    Captostad
    Captotec (Brazil)
    Captotyrol
    Captowa (Japan)
    Captozen
    Captral (Mexico)
    Captrizin
    Captrol (Taiwan)
    Captrol 25 mg x 30's, 100's, 500's
    Cardiace
    Cardiagen
    Tablet; Oral; Captopril 25 mg
    Tablet; Oral; Captopril 50 mg
    Cardilom
    Cardiovaz (Philippines)
    Cardiovaz 25 mg x 100's
    Carditril
    Cardopril (Bangladesh)
    Cardoril 25 (Vietnam)
    Cardoril 25 25 mg x 10 Blister x 10 Tablet
    Catona
    Catonet
    Catoplin (Singapore)
    Catoplin 12.5 mg x 1000's

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