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Carnotprim 12 H

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Carnotprim 12 H uses and description

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Carnotprim 12 H - Used for: Short term treatment of gastroesophageal reflux disease (GERD) in certain patients who do not respond to other therapy. It is used to treat symptoms of a certain digestive problem in diabetic patients (diabetic gastroparesis). It may also be used for other conditions as determined by your doctor.

Carnotprim 12 H is a gastrointestinal stimulant and antinauseant. It works by increasing the movement of the stomach and intestines to help move food and acid out of the stomach more quickly. It also works in certain areas in the brain to decrease nausea.

Pharmacology: Stimulates upper GI tract motility, resulting in accelerated gastric emptying and intestinal transit, and increased resting tone of lower esophageal sphincter. Exerts antiemetic properties through antagonism of central and peripheral dopamine receptors.

Indication: PO

Acute and recurrent diabetic gastroparesis; short-term therapy of symptomatic, documented gastroesophageal reflux disease (GERD) in adults who fail to respond to conventional therapy.

Parenteral

Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy; prevention of postoperative nausea and vomiting when nasogastric suction is undesirable; facilitation of small bowel intubation when tube does not pass pylorus with conventional maneuvers; acute and recurrent diabetic gastric stasis; stimulation of gastric emptying and intestinal transit of barium where delayed emptying interferes with radiological examination of the stomach and/or small intestine.

Unlabeled Uses

Gastric bezoars, hiccups, improvement in lactation, migraines, nausea/vomiting of pregnancy, opioid-induced nausea and vomiting, Tourette syndrome, vascular headache.

Carnotprim 12 H, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Carnotprim 12 H is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Carnotprim 12 H may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.

Oral Diabetic gastric stasis

Adult: 10 mg 4 times/day. To be given 30 minutes before meals and at bedtime. Usual treatment duration: 2-8 wk. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral Nausea and vomiting associated with cancer chemotherapy or radiotherapy

Adult: 2 mg/kg/dose, given 1 hr before start of treatment. Repeat dose 3 times at 2-hrly intervals. May repeat 2 additional doses at 3-hrly intervals if needed. Max: 12 mg/kg/day.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral Gastro-oesophageal reflux disease

Adult: 10-15 mg up to 4 times/day, given 30 minutes before meals and at bedtime, depending on severity of symptoms. If symptoms are intermittent, may give single doses of 20 mg prior to the provoking situation. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Oral Prevent delayed emesis following chemotherapy

Adult: 20-40 mg 2-4 times/day for 3-4 days. Oral Premedication in diagnostic procedures

Adult:

Child: 1 mth-3 yr and up to 14 kg: 100 mcg/kg (max 1 mg); 3-5 yr and 15-19 kg: 2 mg; 5-9 yr and 20-29 kg: 2.5 mg; 9-15 yr and 30-60 kg: 5 mg; 15-18 yr and >60 kg: 10 mg. To be given as a single dose 5-10 minutes before examination. Parenteral Diabetic gastric stasis

Adult: 10 mg 4 times/day via IM/IV admin; to be given 30 minutes before meals and at bedtime. Convert to oral admin when symptoms have subsided sufficiently. Usual treatment duration: 2-8 wk. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Intravenous Nausea and vomiting associated with cancer chemotherapy

Adult: For highly emetogenic drugs/regimens: 2 mg/kg as IV infusion to be given 30 minutes before start of treatment. Repeat twice at 2-hrly intervals after the 1st dose. For less emetogenic drugs/regimens: 1 mg/kg may be used. If vomiting is not well-controlled, may continue with 3 additional doses at 2 mg/kg/dose at 3-hrly intervals; if vomiting is well-controlled with the 1st 3 doses, may reduce dose to 1 mg/kg given at 3-hrly intervals for 3 additional doses.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Intravenous Premedication for radiologic examination of the upper gastrointestinal tract

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intravenous Intubation of the small intestine

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intramuscular Postoperative nausea and vomiting

Adult: 10 mg, given near the end of the procedure. May repeat every 4-6 hr when necessary. Incompatibility: Incompatible with cephalothin sodium, chloramphenicol sodium, and sodium bicarbonate.

Oral Diabetic gastric stasis

Adult: 10 mg 4 times/day. To be given 30 minutes before meals and at bedtime. Usual treatment duration: 2-8 wk. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral Nausea and vomiting associated with cancer chemotherapy or radiotherapy

Adult: 2 mg/kg/dose, given 1 hr before start of treatment. Repeat dose 3 times at 2-hrly intervals. May repeat 2 additional doses at 3-hrly intervals if needed. Max: 12 mg/kg/day.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral Gastro-oesophageal reflux disease

Adult: 10-15 mg up to 4 times/day, given 30 minutes before meals and at bedtime, depending on severity of symptoms. If symptoms are intermittent, may give single doses of 20 mg prior to the provoking situation. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Oral Prevent delayed emesis following chemotherapy

Adult: 20-40 mg 2-4 times/day for 3-4 days. Oral Premedication in diagnostic procedures

Adult:

Child: 1 mth-3 yr and up to 14 kg: 100 mcg/kg (max 1 mg); 3-5 yr and 15-19 kg: 2 mg; 5-9 yr and 20-29 kg: 2.5 mg; 9-15 yr and 30-60 kg: 5 mg; 15-18 yr and >60 kg: 10 mg. To be given as a single dose 5-10 minutes before examination. Parenteral Diabetic gastric stasis

Adult: 10 mg 4 times/day via IM/IV admin; to be given 30 minutes before meals and at bedtime. Convert to oral admin when symptoms have subsided sufficiently. Usual treatment duration: 2-8 wk. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Intravenous Nausea and vomiting associated with cancer chemotherapy

Adult: For highly emetogenic drugs/regimens: 2 mg/kg as IV infusion to be given 30 minutes before start of treatment. Repeat twice at 2-hrly intervals after the 1st dose. For less emetogenic drugs/regimens: 1 mg/kg may be used. If vomiting is not well-controlled, may continue with 3 additional doses at 2 mg/kg/dose at 3-hrly intervals; if vomiting is well-controlled with the 1st 3 doses, may reduce dose to 1 mg/kg given at 3-hrly intervals for 3 additional doses.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Intravenous Premedication for radiologic examination of the upper gastrointestinal tract

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intravenous Intubation of the small intestine

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intramuscular Postoperative nausea and vomiting

Adult: 10 mg, given near the end of the procedure. May repeat every 4-6 hr when necessary. Special Populations: Renal impairment: CrCl <40 mL/min, the starting dose is reduced by 50%. Incompatibility: Incompatible with cephalothin sodium, chloramphenicol sodium, and sodium bicarbonate.

Oral Diabetic gastric stasis

Adult: 10 mg 4 times/day. To be given 30 minutes before meals and at bedtime. Usual treatment duration: 2-8 wk. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral Nausea and vomiting associated with cancer chemotherapy or radiotherapy

Adult: 2 mg/kg/dose, given 1 hr before start of treatment. Repeat dose 3 times at 2-hrly intervals. May repeat 2 additional doses at 3-hrly intervals if needed. Max: 12 mg/kg/day.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary. Oral GERD

Adult: 10-15 mg up to 4 times/day, given 30 minutes before meals and at bedtime, depending on severity of symptoms. If symptoms are intermittent, may give single doses of 20 mg prior to the provoking situation. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Oral Delayed emesis following chemotherapy

Adult: 20-40 mg 2-4 times/day for 3-4 days. Oral Premedication in diagnostic procedures

Adult:

Child: 1 mth–3 yr and up to 14 kg: 100 mcg/kg (max 1 mg); 3–5 yr and 15–19 kg: 2 mg; 5–9 yr and 20–29 kg: 2.5 mg; 9–15 yr and 30–60 kg: 5 mg; 15–18 yr and >60 kg: 10 mg. To be given as a single dose 5–10 minutes before examination. Intravenous Nausea and vomiting associated with cancer chemotherapy

Adult: For highly emetogenic drugs/regimens: 2 mg/kg as IV infusion to be given 30 minutes before start of treatment. Repeat twice at 2-hrly intervals after the 1st dose. For less emetogenic drugs/regimens: 1 mg/kg may be used. If vomiting is not well-controlled, may continue with 3 additional doses at 2 mg/kg/dose at 3-hrly intervals; if vomiting is well-controlled with the 1st 3 doses, may reduce dose to 1 mg/kg given at 3-hrly intervals for 3 additional doses.

Child: Neonate: 100 mcg/kg every 6-8 hr; 1 mth-1 yr (up to 10 kg): 100 mcg/kg (max 1 mg) bid; 1-3 yr (10-14 kg): 1 mg bid-tid; 3-5 yr (15-19 kg): 2 mg bid-tid; 5-9 yr (20-29 kg): 2.5 mg tid; 9-14 yr (≥30 kg): 5 mg tid; 15-19 yr (30-59 kg): 5 mg tid; 15-19 yr (≥60 kg): 10 mg tid. Where wt is less than that specified for a given age group, use the dose corresponding to the wt rather than the age, so that a lower dose is given. Max: 500 mcg/kg. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Intravenous Premedication for radiologic examination of the upper GI tract

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intravenous Intubation of the small intestine

Adult: 10 mg. To be given as a single direct IV inj.

Child: <6 yr: 100 mcg/kg; 6-14 yr: 2.5-5 mg. To be given as a single direct IV inj. Renal impairment: Moderate to severe: Reduce dose by at least 50%. CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50%. Hepatic impairment: Dose reduction may be necessary Intramuscular Postoperative nausea and vomiting

Adult: 10 mg, given near the end of the procedure. May repeat every 4-6 hr when necessary. Parenteral Diabetic gastric stasis

Adult: 10 mg 4 times/day via IM/IV admin; to be given 30 minutes before meals and at bedtime. Convert to oral admin when symptoms have subsided sufficiently. Usual treatment duration: 2-8 wk. Max

Dosage: 500 mcg/kg Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) Dosage Recommendation <40 Reduce dose by at least 50% Hepatic impairment: Dose reduction may be necessary. Incompatibility: Incompatible with cephalothin sodium, chloramphenicol sodium, and sodium bicarbonate.

Indications:

Adult: PO Diabetic gastric stasis 10 mg 4 times/day. Usual duration: 2-8 wk. Nausea and vomiting associated w/ cancer chemotherapy or radiotherapy 2 mg/kg 1 hr before start of treatment. Repeat dose 3 times at 2-hrly intervals. May repeat 2 additional doses at 3-hrly intervals if needed. Max: 12 mg/kg/day. Gastro-oesophageal reflux disease 10-15 mg up to 4 times/day, depending on severity of symptoms. Delayed emesis following chemotherapy 20-40 mg 2-4 times/day for 3-4 days. IV Nausea and vomiting associated w/ cancer chemotherapy Highly emetogenic regimens: 2 mg/kg 30 mins before start of treatment. Repeat twice at 2-hrly intervals. Less emetogenic regimens: 1 mg/kg. If vomiting is not well-controlled, 3 additional doses at 2 mg/kg/dose 3-hrly. If vomiting is well-controlled w/ the 1st 3 doses, may reduce dose to 1 mg/kg 3-hrly for 3 additional doses. Intubation of the small intestine; Premed for radiologic examination of the upper GI tract 10 mg as a single direct inj. IV/IM Diabetic gastric stasis 10 mg 4 times/day. Convert to PO when possible. Usual duration: 2-8 wk. IM Post-op nausea and vomiting 10 mg near the end of the procedure. Repeat 4-6 hrly when needed.

Carnotprim 12 H increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines. Metoclopramide is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms. Metoclopramide is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.

Active ingredients: Metoclopramide
Unit description, dosagePrice, USD
Tablet, Prolonged Release; Oral; Metoclopramide Hydrochloride 15 mg

List of carnotprim 12 h brand and generic drugs

Carnotprim Retard
Capsule, Prolonged Release; Oral; Metoclopramide Hydrochloride 20 mg
Celit
Cerinorm
Cerinorm 10 mg Tablet$ 0.02
Cerucal (Bulgaria, Czech Republic, Estonia, Georgia, Germany, Hungary, Latvia, Lithuania, Romania, Russian Federation, Slovakia)
Drops; Oral; Metoclopramide Hydrochloride
Injectable; Injection; Metoclopramide Hydrochloride 5 mg / ml
Tablet; Oral; Metoclopramide Hydrochloride 10 mg
Cerucal 10mg - 50 Tablets$ 10.40
Cerucal 10mg/2ml - 10 Vial$ 15.60
Cerucal Retard
Capsule, Retard; Oral; Metoclopramide Hydrochloride
Ceruglan
Injectable; Injection; Metoclopramide Hydrochloride 5 mg / ml
Tablet; Oral; Metoclopramide Hydrochloride 10 mg
Cerulan
Injectable; Injection; Metoclopramide Hydrochloride 5 mg / ml
Tablet; Oral; Metoclopramide Hydrochloride 10 mg
Cerureg (Georgia)
Chitou (Taiwan)
Chitou 5 mg x 1000's
Chlorhydrate de Métoclopramide Renaudin (France)
Chlorhydrate de Métoclopramide Richard (France)
Chlorhydrate de Metoclopramide
Injectable; Injection; Metoclopramide Hydrochloride 5 mg / ml
CHLORURE CLOPRAME
Cirulan
Citroplus
Clinamide
Clodaset (Mexico)
Clomet
Clomet 60 ml Syrup$ 0.03
Clomet 10 mg Tablet$ 0.02
Clomet Inj
Clomet Inj 10 mg Injection$ 0.04
Clop (Venezuela)
0.05 % x 15ml$ 0.65
0.05 % x 10g$ 0.40
0.05 % x 30g$ 0.80
Clop 0.05% LOTION / 15ml$ 0.65
Clop 0.05% OINT / 10g$ 0.40
Clop 0.05% OINT / 30mg$ 0.80
0.05 % w/w x 30g$ 1.12
Clop 75 mg Tablet$ 0.06
Clop Skin 30 gm Cream$ 1.12
Clop Skin 10 gm Cream$ 0.56
Clop Skin 15 ml Lotion$ 0.85
Clop 0.05% w/w CRM / 30g$ 1.12
Clopamon (South Africa)
Clopan (Ecuador)
Cloperan (Malta)
Clopra
Tablet; Oral; Metoclopramide Hydrochloride 10 mg

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