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Caspofungin

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Caspofungin uses and description

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Caspofungin - Caspofungin is an antibiotic that fights infections caused by fungus.

Caspofungin is used to treat fungal infections that involve the stomach, lungs, esophagus, or other internal body areas.

Caspofungin may also be used for purposes not listed in this medication guide.

Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however in vitro resistance development to Caspofungin by Aspergillus species has not been studied.

Intravenous Invasive aspergillosis

Adult: Loading dose: 70 mg on day 1, to be infused over 1 hr followed by subsequent doses of 50 mg/day or 70 mg/day in patients weighing >80 kg. Duration of treatment depends on patient's clinical response and underlying disease. Hepatic impairment: Moderate hepatic impairment (Child-Pugh score 7-9): 35 mg daily is recommended. However, a loading dose of 70 mg should still be administered on Day 1. Intravenous Oesophageal candidiasis

Adult: 50 mg infused over 1 hr daily. Intravenous Invasive candidiasis

Adult: Loading dose: 70 mg on day 1, to be infused over 1 hr followed by maintenance doses of 50 mg/day. Patients weighing >80 kg or receiving carbamazepine, dexamethasone, efavirenz, nevirapine, phenytoin and rifampin may require an increased daily dose of Caspofungin (70 mg/day) if response to 50 mg/day is inadequate. Usual treatment duration: 14 days since the last positive culture; longer duration may be needed in patients who are persistently neutropenic. Hepatic impairment: Moderate hepatic impairment (Child-Pugh score 7-9): 35 mg daily is recommended. However, a loading dose of 70 mg should still be administered on Day 1. Special Populations: Hepatic impairment: Mild (Child-Pugh score 5-6): No adjustment needed. Moderate (Child-Pugh score 7-9): Invasive Aspergillus infection: Reduce daily dose to 35 mg (after initial 70-mg dose).Esophageal candidiasis: 35 mg/day. Reconstitution: Allow refrigerated vial to reach room temperature. Reconstitute using 0.9% sodium chloride, sterile water for inj, or bacteriostatic water for inj. Mix gently to form clear solution; otherwise, do not use. Further dilute with 0.9%, 0.45%, or 0.225% sodium chloride or lactated ringer's inj. Incompatibility: Do not mix with dextrose-containing solutions or coadminister with other medications.

Indications:

Adult: IV Invasive aspergillosis 70 mg via infusion as loading dose, then 50 mg/day or 70 mg/day in patients weighing >80 kg. Oesophageal candidiasis 50 mg/day. Invasive candidiasis 70 mg via infusion as loading dose, then 50 mg/day. Patients weighing >80 kg or receiving enzyme inducer: 70 mg/day if response to 50 mg/day is inadequate. Usual treatment duration: 14 days after the last positive culture.

Active ingredients: Caspofungin
Unit description, dosagePrice, USD
Cancidas iv 70 mg vial$ 421.06
Cancidas iv 50 mg vial$ 405.25

List of caspofungin brand and generic drugs

Cancidas (Algeria, Argentina, Aruba, Australia, Austria, Bahamas, Barbados, Belgium, Belize, Bosnia & Herzegowina, Brazil, Canada, Cayman Islands, Chile, China, Colombia, Croatia (Hrvatska), Czech Republic, Denmark, Dominican Republic, Ecuador, Finland, France, Germany, Greece, Hong Kong, Hungary, Iceland, Ireland, Israel, Italy, Jamaica, Luxembourg, Malaysia, Mexico, Netherlands, Netherlands Antilles, New Zealand, Norway, Peru, Philippines, Romania, Russian Federation, Serbia, Singapore, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, Trinidad & Tobago, Tunisia, Turkey, United Kingdom, United States, Venezuela)
Injectable; IV (Infusion); Caspofungin Acetate 50 mg
Injectable; IV (Infusion); Caspofungin Acetate 70 mg
Cancidas (vial) 50 mg x 1's$ 444.24
Cancidas 70 mg x 1's$ 572.27
50 mg x 10 mL x 1's$ 231.48
70 mg x 10 mL x 1's$ 231.48
Cancidas 50 mg x 1's
10.8 milliliter in 1 vial, single-use
Cancidas 50mg x 10mL INJ / 10ml$ 231.48
Cancidas 70mg x 10mL INJ / 10ml$ 231.48
Cancidas 50 mg Injection$ 0.22
Candidas (Australia)
Casfung
Casfung 50mg INJ / 1$ 165.19
Casfung 70mg INJ / 1$ 165.19
Caspercid
Caspercid 50mg x 10mL INJ / 10ml$ 220.37
Caspercid 70mg x 10mL INJ / 10ml$ 220.37
Caspofungin MSD
Injectable; IV (Infusion); Caspofungin Acetate 50 mg
Injectable; IV (Infusion); Caspofungin Acetate 75 mg
Caspogin
Caspogin 50mg INF / 10ml$ 185.00
Caspogin 70mg INF / 10ml$ 185.00
Casporan
Casporan 50mg INJ / 1$ 147.78
Casporan 70mg INJ / 1$ 147.78
Intravenous Infusion Cancidas (United States)
Savacap
Savacap 50mg INJ / 1$ 147.78
Savacap 70mg INJ / 1$ 147.78
 
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