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Chlorothiazide

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Chlorothiazide uses and description

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Chlorothiazide - Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Chlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).

Chlorothiazide may also be used for other purposes not listed in this medication guide.

Pharmacology: Enhances excretion of sodium, chloride, and water by interfering with transport of sodium ions across renal tubular epithelium.

Indication: Adjunctive treatment in edema associated with CHF, hepatic cirrhosis, and corticosteroid and estrogen therapy; edema caused by various forms of renal function impairment such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure (oral and IV); management of hypertension (oral).

Unlabeled Uses

Calcium nephrolithiasis; diabetes insipidus; osteoporosis.

Like other thiazides, Chlorothiazide promotes water loss from the body (diuretics). It inhibits Na reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.

Indications:

Adult: PO HTN 250-500 mg/day, up to 1 g/day. Oedema 0.25-1 g 1-2 times/day. Max: 2 g/day.

Oral Hypertension

Adult: 250-500 mg daily as single or divided dose. Up to 1 g daily. May be given via IV admin using the sodium salt.

Child: Up to 25 mg/kg daily in 2 divided doses. Infants up to 6 mth: Up to 35 mg/kg daily in 2 divided doses. Oral Oedema

Adult: 0.25-1 g once daily or bid, may also be taken on alternate days or on 3-5 days wkly. Max: 2 g/day. May be given via IV admin using the sodium salt.

Active ingredients: Chlorothiazide
Unit description, dosagePrice, USD
Tablet; Oral; Chlorothiazide 250 mg
Tablet; Oral; Chlorothiazide 500 mg
Diuril sodium 500 mg vial$ 519.62
Chlorothiazide sod 500 mg vial$ 357.24
Microzide 12.5 mg capsule$ 0.95
Aldoclor 250-250 mg tablet$ 0.67
Chlorothiazide 500 mg tablet$ 0.36
Chlorothiazide 250 mg tablet$ 0.28

List of chlorothiazide brand and generic drugs

Chlorosal
Chlorothiazide Sodium APP (United States)
Chlorothiazide Sodium Sun (United States)
Chlorurit
Chlorzide
Chlotride
Chlrosal
Clotride
Diachlor
Diurigen
Diuril (United States)
Suspension; Oral; Chlorothiazide Sodium 250 mg / 5 ml
Tablet; Oral; Chlorothiazide Sodium 250 mg
Tablet; Oral; Chlorothiazide Sodium 500 mg
Injectable; Injection; Chlorothiazide Sodium 500 mg
237 milliliter in 1 bottle
Diuril Boluses
Diuril Lyovac
Diuril Sodium Intravenous
Diurilix
Diurite
Diutrid
Flumen
Intravenous Sodium Diuril (United States)
Lyovac Diuril
Minzil
Neo-Dema
Pahtlisan
Salisan
Salunil
Saluretil
Saluric
SK-Chlorothiazide
Thiazide (India)
Thiazide 12.5mg TAB / 10$ 0.17
Thiazide 25mg TAB / 10$ 0.28
12.5 mg x 10's$ 0.17
25 mg x 10's$ 0.28
Tablets; Oral; Hydrochlorothiazide 12.5 mg
Tablets; Oral; Hydrochlorothiazide 25 mg
Thiazide 12.5 mg Tablet$ 0.02
Thiazide 25 mg Tablet$ 0.03
Warduzide

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