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Cionamat

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Cionamat uses and description

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Cionamat consists of Clonazepam, Lamotrigine.

Clonazepam - Used for: Controlling certain types of seizures in the treatment of epilepsy and for the treatment of panic disorders. It may also be used for other conditions as determined by your doctor.

Cionamat (Clonazepam) is a benzodiazepine. It works by increasing the activity of a naturally occurring chemical in the brain.

Pharmacology: Potentiates action of GABA, inhibitory neurotransmitter, resulting in increased neuronal inhibition and CNS depression, especially in limbic system and reticular formation.

Indication: Treatment of Lennox-Gastaut syndrome; management of akinetic and myoclonic seizures and absence seizures unresponsive to succinimides; panic disorders.

Unlabeled Uses

Treatment of restless legs syndrome, parkinsonian dysarthria, acute manic episodes of bipolar affective disorder, multifocal tic disorders and neuralgias; adjunctive therapy for schizophrenia.

Cionamat (Clonazepam) is an antiepileptic drugs from the group of benzodiazepine derivatives. This medication has a pronounced anticonvulsant and central muscle relaxant, anxiolytic, sedative and hypnotic effects.

Cionamat (Clonazepam) strengthens the inhibitory effect of GABA on the transmission of nerve impulses.

Anxiolytic effects of this drug is due to the influence on the amygdaloid complex of the limbic system and appears in reducing the emotional stress, reduce anxiety, fear, anxiety.

The sedation effects is due to the influence on the reticular formation of the brainstem and nonspecific thalamic nucleus and manifests a decrease in neurotic symptoms (anxiety, fear).

Anticonvulsant effect is realized by increasing presynaptic inhibition.

The central muscle relaxant effect is due to inhibition of spinal polysynaptic afferent inhibitory ways (to a lesser extent and monosynaptic).

It is possibly and direct inhibition of motor nerves and muscle function.

Cionamat (Clonazepam), a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus.

Cionamat (Clonazepam) is used to treat epilepsy (also known as seizures or fits). Cionamat (Clonazepam) is also used to treat panic attacks and schizophrenia.

Oral Epilepsy

Adult: Initially, 1 mg given at night for 4 nights, gradually increased over 2-4 wk.

Maintenance: 4-8 mg daily. Max: 20 mg/day

Child: 1-5 yr: 250 mcg daily; 5-12 yr: 500 mcg daily. Maintenance (given in 2-4 divided doses): Infants: 0.5-1 mg daily; 1-5 yr: 1-3 mg daily; 5-12 yr: 3-6 mg daily. Max: 200 mcg/kg/day

Elderly: Initially, 500 mcg at night for 4 nights, may gradually increase over 2-4 wk. Hepatic impairment: Dose reduction may be needed. Oral Panic disorder

Adult: Initially, 250 mcg bid, increased after 3 days up to 1 mg daily. Max: 4 mg daily. Hepatic impairment: Dose reduction may be needed. Intravenous Emergency management of status epilepticus

Adult: 1 mg as inj or infusion given over at least 2 min, repeated if necessary.

Child: and infants: 500 mcg as inj or infusion given over at least 2 min, repeated if necessary. Hepatic impairment: Dose reduction may be needed.

Indications:

Adult: PO Epilepsy Initial: 1 mg/day at night for 4 nights, may increase gradually.

Maintenance: 4-8 mg/day. Max: 20 mg/day. Panic disorder Initial: 250 mcg twice daily. Max: 4 mg/day. IV Emergency treatment of status epilepticus 1 mg as inj or infusion, repeat if needed.

used to control certain types of seizures in the treatment of epilepsy and for the treatment of panic disorders. Clonazepam may also be used for other purposes not listed in this medication guide.

Lamotrigine - Pharmacology: Chemically unrelated to existing antiepileptic drugs (AEDs); precise mechanism(s) unknown. One proposed mechanism suggests inhibition of voltage-sensitive sodium channels, thereby stabilizing neuronal membranes that modulate presynaptic transmitter release of excitatory amino acids (eg, aspartate, glutamate).

Indication: Bipolar disorder (immediate release only)

Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes in adults treated for acute mood episodes with standard therapy.

Epilepsy

Adjunctive therapy for partial seizures, the generalized seizures of Lennox-Gastaut syndrome, and primary generalized tonic-clonic seizures in adults and children 2 yr of age and older (immediate release); for partial-onset seizures with or without secondary generalization and primary generalized tonic-clonic seizures in patients at least 13 yr of age (ER); conversion to monotherapy in adults with partial seizures who are receiving treatment with carbamazepine, phenobarbital, phenytoin, primidone, or valproate as a single AED (immediate release).

Unlabeled Uses

Management of children with absence seizures, juvenile myoclonic epilepsy, and temporal lobe seizures; postpoliomyelitis syndrome; prevention of migraines in adults; rectal administration.

Cionamat (Lamotrigine), an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Cionamat (Lamotrigine) is also used in the treatment of depression and bipolar disorder. Cionamat (Lamotrigine) is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Cionamat (Lamotrigine) inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.

Cionamat (Lamotrigine) is used to treat epilepsy (also known as fits or seizures). It may be used on its own or together with other epilepsy medicines. It is also used to treat a mood disturbance called bipolar disorder.

Oral Epilepsy

Adult: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100-200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily.

Child: >12 yr: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100 -200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. <12 yr: Not recommended. Max

Dosage:

Adult: 500 mg daily. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Adjunct in epilepsy

Adult: With valproate: Initially, 25 mg on alternate days for 2 wk followed by 25 mg once daily for 2 wk; thereafter, increase by a max of 25-50 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses. With enzyme-inducing antiepileptics but not with valproate: 50 mg once daily for 2 wk followed by 50 mg bid for 2 wk; thereafter, increase by a max of 100 mg every 1-2 wk; usual maintenance doses: 200-400 mg/day in 2 divided doses; up to 700 mg/day in some patients. With oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter increase dose by a max of 50-100 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses; up to 500 mg daily in some patients.

Child: With valproate: Initially, 0.15 mg/kg once daily for 2 wk followed by 0.3 mg/kg once daily for 2 wk; thereafter, increase by a max of 0.3 mg/kg every 1-2 wk to usual maintenance doses of 1-5 mg/kg once daily or in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Bipolar disorder

Adult: Monotherapy: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 200 mg daily. Max dose: 200 mg/day. With valproate: Initially, 25 mg every other day for 2 wk followed by 25 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 100 mg daily. With enzyme-inducing antiepileptics but not with valproate: Initially, 50 mg once daily for 2 wk followed by 100 mg daily in 2 divided doses for 2 wk; thereafter, increase in 100-mg increments wkly to usual maintenance dose of 400 mg daily in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%.

Indications:

Adult: PO Epilepsy Initial: 25 mg once daily for 2 wk, then 50 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. Up to 500 mg/day in some patients. Adjunct in epilepsy W/ valproate: Initial: 25 mg on alternate days for 2 wk, followed by 25 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. W/ enzyme-inducing antiepileptics (except valproate): 50 mg once daily for 2 wk, followed by 50 mg twice daily for 2 wk.

Maintenance: 200-400 mg/day. Up to 700 mg/day in some patients. W/ oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. Up to 500 mg/day in some patients. Bipolar disorder Monotherapy: Initial : 25 mg once daily for 2 wk, increase gradually to maintenance dose: 200 mg/day. W/ valproate: Initial: 25 mg every other day for 2 wk, increase gradually to

Maintenance: 100 mg/day. W/ enzyme-inducing drugs (except valproate): Initial: 50 mg once daily for 2 wk, then increase gradually to

Maintenance: 400 mg/day in 2 divided doses.

Oral Epilepsy

Adult: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100-200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily.

Child: >12 yr: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100 -200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. <12 yr: Not recommended. Max

Dosage:

Adult: 500 mg daily. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Adjunct in epilepsy

Adult: With valproate: Initially, 25 mg on alternate days for 2 wk followed by 25 mg once daily for 2 wk; thereafter, increase by a max of 25-50 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses. With enzyme-inducing antiepileptics but not with valproate: 50 mg once daily for 2 wk followed by 50 mg bid for 2 wk; thereafter, increase by a max of 100 mg every 1-2 wk; usual maintenance doses: 200-400 mg/day in 2 divided doses; up to 700 mg/day in some patients. With oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter increase dose by a max of 50-100 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses; up to 500 mg daily in some patients.

Child: With valproate: Initially, 0.15 mg/kg once daily for 2 wk followed by 0.3 mg/kg once daily for 2 wk; thereafter, increase by a max of 0.3 mg/kg every 1-2 wk to usual maintenance doses of 1-5 mg/kg once daily or in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Bipolar disorder

Adult: Monotherapy: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 200 mg daily. Max dose: 200 mg/day. With valproate: Initially, 25 mg every other day for 2 wk followed by 25 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 100 mg daily. With enzyme-inducing antiepileptics but not with valproate: Initially, 50 mg once daily for 2 wk followed by 100 mg daily in 2 divided doses for 2 wk; thereafter, increase in 100-mg increments wkly to usual maintenance dose of 400 mg daily in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Special Populations: Reduce dose by 50% in patients with moderate hepatic impairment and 75% in severe hepatic impairment.

Epilepsy:Adjunctive Use: Cionamat (Lamotrigine) is indicated as adjunctive therapy for partial seizures and also the generalized seizures of Lennox-Gastaut syndrome in adults and pediatric patients (>/=2 years of age).Monotherapy Use: Cionamat (Lamotrigine) is indicated for conversion to monotherapy in adults with partial seizures. Bipolar Disorder: Cionamat (Lamotrigine) is indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes).

Used for: Your medicine is called Cionamat (Lamotrigine) Dispersible Tablets.

The active ingredient is Lamotrigine. Cionamat (Lamotrigine) belong to a group of medicines called anticonvulsants (antiepileptics). Cionamat (Lamotrigine) is used to treat the following types of seizures (fits or convulsions) due to bursts of abnormal electrical activity in the brain:

  • Simple partial seizures (in which consciousness is retained) that affect one side of the brain
  • Complex partial seizures (in which consciousness is impaired or lost) that affect one side of the brain
  • Generalised tonic-clonic seizures (loss of consciousness, generalised muscle contraction [tonic] followed by shaking or convulsions [clonic]) that affect both sides of the brain
  • Seizures associated with Lennox-Gastaut Syndrome an uncommon form of epilepsy with variable symptoms affecting a small proportion of children with epilepsy.

Your medicine may be used on its own to treat adults and children over 12 years.

Your medicine can also be used in combination with other anti-epileptic medicines in both adults and children age 2 years and over.

Active ingredients: Clonazepam/Lamotrigine
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Clonazepam/Lamotrigine (Mexico)
 
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