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Cipla-Simvastatin

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Cipla-Simvastatin uses and description

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Cipla-Simvastatin - Pharmacology: Increases the rate at which the body removes cholesterol from blood and reduces production of cholesterol by inhibiting the enzyme that catalyzes an early rate-limiting step in cholesterol synthesis.

Indication: Heterozygous Familial Hypercholesterolemia in Adolescents

As an adjunct to diet to reduce total cholesterol, LDL-cholesterol, and apolipoprotein B (apo B) levels in adolescent boys and girls 10 to 17 y who are at least 1 y postmenarche with heterozygous familial hypercholesterolemia, if, after an adequate trial of diet therapy, LDL-cholesterol remains at 190 mg/dL or higher, or LDL-cholesterol remains at 160 mg/dL or higher and there is a positive family history of premature CV disease or 2 or more other CV disease risk factors are present.

Hyperlipidemia

For the reduction of elevated total cholesterol, LDL-cholesterol, apo B and triglyceride levels, and to increase HDL-cholesterol in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb); to reduce elevated triglyceride levels in patients with hypertriglyceridemia (Fredrickson type IV hyperlipemia); to reduce elevated triglyceride and VLDL-cholesterol in patients with primary dysbetalipoproteinemia (Fredrickson type III hyperlipidemia); to reduce total cholesterol and LDL-cholesterol in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (eg, LDL apheresis) or if such treatments are unavailable.

Prevention of Coronary Events

In patients at high risk of coronary events from existing coronary heart disease (CHD), diabetes, peripheral vessel disease, or history of stroke or other cerebrovascular disease, to reduce the risk of total mortality by reducing CHD deaths, reduce the risk of nonfatal MI and stroke, and reduce the need for coronary and noncoronary revascularization procedures.

Unlabeled Uses

Multiple sclerosis.

Used for: Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It is used in certain patients to reduce the risk of heart attack, stroke, and death due to coronary heart disease. It is also used to reduce the need for medical procedures to open blocked blood vessels. It is also used in certain patients to reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina. It may also be used for other conditions as determined by your doctor.

Cipla-Simvastatin is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.

Cipla-Simvastatin is a hypolipidemic agent from a group of statins, an inhibitor of HMG-CoA reductase. This medication is a prodrug because it has in its structure the closed lactone ring which is hydrolyzed after intake.

Lipid-lowering effect of statins is associated with lower levels of total cholesterol by LDL-C. Reducing cholesterol is dose-dependent and is not linear but exponential. Statins do not affect the activity of lipoprotein and hepatic lipase, have no significant effect on the synthesis and catabolism of free fatty acids, thats why their effect on TG levels again and indirectly through their main effects on reducing LDL-C.

According to the controlled studies of Cipla-Simvastatin increases HDL-C to 14%.

In addition to the hypolipidemic actions Cipla-Simvastatin has beneficial effects in endothelial dysfunction (pre-clinical sign of early atherosclerosis), on the vascular wall, the state of atheroma, improves blood rheology, have antioxidant, antiproliferative properties. There is evidence that Cipla-Simvastatin improves endothelial function within 30 days of therapy.

Cipla-Simvastatin therapy was accompanied by a decrease in the incidence of cardiovascular disorders, regardless of baseline LDL-C.

Cipla-Simvastatin [Usan:Ban:Inn], the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Cipla-Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Indications:

  • to treat coronary heart disease (CHD) and high cholesterol
  • to reduce the risk of death by reducing coronary death;
  • to reduce the risk of heart attack;
  • to reduce the risk for undergoing cardiac procedures
  • to reduce the risk of stroke or transient ischemic attack (TIA).

  • Cipla-Simvastatin helps lower your cholesterol level. Excessive cholesterol in your body can clog up your blood vessels. This can lead to many health problems such as strokes and heart disease, including heart attacks. Cipla-Simvastatin is meant to be taken as part of a complete cholesterol management programme that should include exercise, a healthy diet and lifestyle.

    Oral Hyperlipidaemias

    Adult: Initially, 10-20 mg/day, to be taken in the evening. May start with 40 mg once daily in patients with high CV risk or require a large reduction in cholesterol. For patients with moderate CV risk, initiate with 10 mg once daily. May adjust dose at intervals of at least 4 wk. Max: 80 mg once daily. For patients with homozygous familial hypercholesterolaemia: 40 mg once daily in the evening or 80 mg daily (given in 3 divided doses of 20 mg, 20 mg and an evening dose of 40 mg). Renal impairment: Severe impairment: initially, 5 mg once daily with close monitoring. Oral Cardiovascular risk reduction

    Adult: In high-risk patients (e.g. patients with DM or atherosclerotic cardiovascular disease): 20-40 mg once daily. Moderate-risk patients: 10 mg once daily. Renal impairment: Severe impairment: initially, 5 mg once daily with close monitoring. Special Populations: For patients taking drugs that interact with simvastatin, initially, 5 mg once daily. Max: 10 mg/day (for patients taking ciclosporin, fibrates or nicotinic acid) and 20 mg/day (for patients taking amiodarone or verapamil).

    Indications:

    Adult: PO Hyperlipidaemias Initial: 10-20 mg/day. May adjust dose at intervals of at least 4 wk. Max: 80 mg/day. CV risk reduction In high-risk patients: 20-40 mg once daily. Moderate-risk patients: 10 mg once daily.

    Oral Hyperlipidaemias

    Adult: Initially, 10-20 mg/day, to be taken in the evening. May start with 40 mg once daily in patients with high CV risk. For patients with moderate CV risk, initiate with 10 mg once daily. May adjust dose at 4-wkly intervals. Max: 80 mg/day. Renal impairment: Severe impairment: initially, 5 mg once daily. Doses >10 mg daily should be used with caution. Oral Prevention of cardiovascular events

    Adult: Initially, 10-20 mg/day, to be taken in the evening. May start with 40 mg once daily in patients with high CV risk. For patients with moderate CV risk, initiate with 10 mg once daily. May adjust dose at 4-wkly intervals. Max: 80 mg/day. Renal impairment: Severe impairment: initially, 5 mg once daily. Doses >10 mg daily should be used with caution. Oral Homozygous familial hypercholesterolaemia

    Adult: Initially, 40 mg once daily. May increase dose to 80 mg daily, given in 3 divided doses.

    Child: 10-17 yr: Initially, 10 mg daily. May increase to 40 mg daily according to response. Renal impairment: Severe impairment: initially, 5 mg once daily. Doses >10 mg daily should be used with caution. Special Populations: For patients taking drugs that interact with simvastatin, initially, 5 mg once daily. Max: 10 mg/day (for patients taking ciclosporin, fibrates or nicotinic acid) and 20 mg/day (for patients taking amiodarone or verapamil).

    Active ingredients: Simvastatin
    Unit description, dosagePrice, USD

    List of cipla-simvastatin brand and generic drugs

    Christatin (Greece)
    Clinart (Italy)
    Clinfar
    CO Simvastatin (Canada)
    Tablet; Oral; Simvastatin 10 mg
    Tablet; Oral; Simvastatin 20 mg
    Tablet; Oral; Simvastatin 40 mg
    Tablet; Oral; Simvastatin 5 mg
    Tablet; Oral; Simvastatin 80 mg
    Tablets; Oral; Simvastatin 10 mg
    Tablets; Oral; Simvastatin 20 mg
    Tablets; Oral; Simvastatin 40 mg
    Tablets; Oral; Simvastatin 5 mg
    Tablets; Oral; Simvastatin 80 mg
    Coledis
    Colemin (Spain)
    Colemin Forte (Spain)
    Colesken
    Tablet; Oral; Simvastatin 10 mg
    Tablet; Oral; Simvastatin 20 mg
    Tablets; Oral; Simvastatin 10 mg
    Tablets; Oral; Simvastatin 20 mg
    Colestop (El Salvador, Nicaragua)
    Colestricon (Philippines)
    Cordiron
    Corolin
    Corr (Poland)
    Corsim (Czech Republic)
    Corstat (Hongkong)
    Corstat 10 mg x 2 x 14's
    Corstat 20 mg x 2 x 14's
    Cotritev
    Tablet; Oral; Simvastatin 10 mg
    Tablet; Oral; Simvastatin 20 mg
    Tablet; Oral; Simvastatin 40 mg
    Tablet; Oral; Simvastatin 80 mg
    Tablets; Oral; Simvastatin 10 mg
    Tablets; Oral; Simvastatin 20 mg
    Tablets; Oral; Simvastatin 40 mg
    Tablets; Oral; Simvastatin 80 mg
    Covastin (Singapore, Sri Lanka)
    Covastin 10 mg x 30's$ 250.00
    Covastin 20 mg x 30's$ 280.00
    Covastin 40 mg x 30's$ 300.00
    Tablets, Film-Coated; Oral; Simvastatin 10 mg
    Tablets, Film-Coated; Oral; Simvastatin 20 mg
    Tablets, Film-Coated; Oral; Simvastatin 40 mg

    Show all Cipla-Simvastatin generic names
     
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