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Clomipramine

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Clomipramine uses and description

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Clomipramine - Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced.

Clomipramine is used to treat symptoms of obsessive-compulsive disorder (OCD) such as recurrent thoughts or feelings and repetitive actions.

Clomipramine may also be used for purposes other than those listed in this medication guide.

Clomipramine, a tricyclic antidepressant, is the 3-chloro derivative of Imipramine. It was thought that tricyclic antidepressants work exclusively by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: α1 and β1 receptors are sensitized, α2 receptors are desensitized (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain.

Clomipramine is used to treat depression. It can also be used to treat obsessive-compulsive disorder (OCD), panic disorders, phobias and post-traumatic stress disorder. Clomipramine can also be used to treat other conditions such as certain sleep disorders, nerve-related pain and adult bed-wetting.

Oral Adjunct for cataplexy associated with narcolepsy

Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily.

Elderly: Dose reduction may be needed. Max

Dosage: Oral Obsessive compulsive disorder

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Panic disorder

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Phobias

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Depression

Adult: Initially, 10 mg daily; may increase gradually to 30-150 mg daily if needed. Up to 250 mg daily or more may be required in more severe cases.

Elderly: Initially, 10 mg daily; may increase gradually over 10 days to 30-75 mg daily. Max

Dosage: 100-150 mg daily. Intramuscular Depression

Adult: Initially, 25-50 mg daily, may increase dose gradually. Max: 100-150 mg daily. Substitute with oral dosage as soon as possible.

Elderly: Initially, 10 mg daily gradually increased to 30-75 mg if necessary. Intramuscular Obsessive compulsive disorder

Adult: Initially, 25-50 mg daily, may increase dose gradually. Max: 100-150 mg daily. Substitute with oral dosage as soon as possible.

Elderly: Initially, 10 mg daily gradually increased to 30-75 mg if necessary. Intravenous Depression

Adult: Initially, 50-75 mg diluted in 250-500 ml of 0.9% sodium chloride or 5% glucose infused over 1.5-3 hr. Substitute with oral therapy when a satisfactory response has been achieved. The initial oral dose can be double the max parenteral dose; adjust subsequently according to response. Intravenous Obsessive compulsive disorder

Adult: Initially, 50-75 mg diluted in 250-500 ml of 0.9% sodium chloride or 5% glucose infused over 1.5-3 hr. Substitute with oral therapy when a satisfactory response has been achieved. The initial oral dose can be double the max parenteral dose; adjust subsequently according to response.

Indications:

Adult: PO Adjunct in cataplexy associated w/ narcolepsy Initial: 10 mg/day, up to 75 mg/day. Obsessive-compulsive disorder; Panic disorder ; Phobias Initial: 25 mg/day, gradually increase up to 100-150 mg/day if needed. Max: 250 mg/day. Depression Initial: 10 mg/day, up to 30-150 mg/day if needed. ≥250 mg/day may be needed in severe cases. IV Depression; Obsessive-compulsive disorder Initial: 50-75 mg/day via infusion. Substitute w/ oral therapy as soon as possible. IM Depression; Obsessive-compulsive disorder Initial: 25-50 mg/day. Max: 100-150 mg/day.

Oral Adjunctive treatment for cataplexy associated with narcolepsy

Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily.

Elderly: Dose reduction may be needed. Max

Dosage: Oral Panic disorder

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Phobias

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Obsessive-compulsive disorders

Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.

Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.

Elderly: Initially, 10 mg daily. Oral Depression

Adult: Initially, 10 mg daily; may increase gradually to 30-150 mg daily if needed. Up to 250 mg daily or more may be required in more severe cases.

Elderly: Initially, 10 mg daily; may increase gradually over 10 days to 30-75 mg daily. Max

Dosage: 100-150 mg daily. Intravenous Depression

Adult: Initially, 50-75 mg diluted in 250-500 ml of 0.9% sodium chloride or 5% glucose infused over 1.5-3 hr. Substitute with oral therapy when a satisfactory response has been achieved. The initial oral dose can be double the max parenteral dose; adjust subsequently according to response. Intravenous Obsessive compulsive disorder

Adult: Initially, 50-75 mg diluted in 250-500 ml of 0.9% sodium chloride or 5% glucose infused over 1.5-3 hr. Substitute with oral therapy when a satisfactory response has been achieved. The initial oral dose can be double the max parenteral dose; adjust subsequently according to response. Intramuscular Depression

Adult: Initially, 25-50 mg daily, may increase dose gradually. Max: 100-150 mg daily. Substitute with oral dosage as soon as possible.

Elderly: Initially, 10 mg daily gradually increased to 30-75 mg if necessary. Intramuscular Obsessive compulsive disorder

Adult: Initially, 25-50 mg daily, may increase dose gradually. Max: 100-150 mg daily. Substitute with oral dosage as soon as possible.

Elderly: Initially, 10 mg daily gradually increased to 30-75 mg if necessary.

Indications: Edogenous depression.

Obsessive compulsive neurosis and phobic states.

Active ingredients: Clomipramine
Unit description, dosagePrice, USD
Capsule; Oral; Clomipramine Hydrochloride 25 mg
Capsule; Oral; Clomipramine Hydrochloride 50 mg
Capsule; Oral; Clomipramine Hydrochloride 75 mg
Tablet, Film-Coated; Oral; Clomipramine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Clomipramine Hydrochloride 25 mg
Tablet, Film-Coated; Oral; Clomipramine Hydrochloride 75 mg
Tablet; Oral; Clomipramine Hydrochloride 10 mg
Tablet; Oral; Clomipramine Hydrochloride 25 mg
Tablet; Oral; Clomipramine Hydrochloride 75 mg
Tablet; Oral; Clomipramine Hydrochloride 50 mg
Capsule; Oral; Clomipramine Hydrochloride 10 mg
Clomipramine hcl powder$ 17.88
Anafranil 25 mg capsule$ 13.51
Anafranil 50 mg capsule$ 13.51
Anafranil 75 mg capsule$ 13.24
ClomiPRAMINE HCl 75 mg capsule$ 1.55
Clomipramine 75 mg capsule$ 1.33
Clomipramine 50 mg capsule$ 1.01
ClomiPRAMINE HCl 25 mg capsule$ 0.88
Anafranil 50 mg Tablet$ 0.77
Clomipramine 25 mg capsule$ 0.75
ClomiPRAMINE HCl 50 mg capsule$ 0.57
Apo-Clomipramine 50 mg Tablet$ 0.43
Co Clomipramine 50 mg Tablet$ 0.43
Anafranil 25 mg Tablet$ 0.42
Anafranil 10 mg Tablet$ 0.31
Apo-Clomipramine 25 mg Tablet$ 0.23
Co Clomipramine 25 mg Tablet$ 0.23
Apo-Clomipramine 10 mg Tablet$ 0.17
Co Clomipramine 10 mg Tablet$ 0.17
Clomipramine 10 mg Capsule$ 0.03

List of clomipramine brand and generic drugs

Clomipramin-ratiopharm (Germany)
Clomipramine (chlorhydrate) Mylan (France)
Clomipramine 10
Clomipramine HCl A (Netherlands)
Clomipramine HCl Actavis (Netherlands)
Clomipramine HCl CF (Netherlands)
Clomipramine HCl Merck (Netherlands)
Clomipramine HCl Mylan (Netherlands)
Clomipramine HCl PCH (Netherlands)
Clomipramine HCl ratiopharm (Netherlands)
Clomipramine HCl Sandoz (Netherlands)
Clomipramine Merck (Tunisia)
Clomipramine Mylan (Tunisia)
Clomipramine RPG (France)
Clomipramine Sandoz (France)
Clomipramine Teva (France)
Clomipraminhydrochlorid 2care4 (Denmark)
Clomipran
Clomistar SR
Clomistar SR 75 mg Tablet$ 0.21
Clomizil (India)
Clomizil 25mg CAP / 15$ 0.65
25 mg x 15's$ 0.65
Clomizil 25 mg Capsule$ 0.04
Clomizip
Clomizip 25 mg Capsule$ 0.04
CLONIL (India)
CLONIL Capsule/ Tablet / 25mg (10 units)$ 0.76
CLONIL Modified Release Capsule/ Tablet / 75mg (10 units)$ 2.04
CLONIL Capsule/ Tablet / 50mg (10 units)$ 1.21
CLONIL Capsule/ Tablet / 10mg (10 units)$ 0.32
Clonil 10mg TAB / 10$ 0.28
Clonil 20mg TAB / 10$ 0.57
Clonil 50mg TAB / 10$ 1.03
Clonil 75mg SR-TAB / 10$ 1.70
10 mg x 10's$ 0.28
25 mg x 10's$ 0.57
50 mg x 10's$ 1.03
75 mg x 10's$ 1.70
Clonil 50 mg Tablet$ 0.13
Clonil 25 mg Tablet$ 0.09
Clonil 10 mg Tablet$ 0.04
Clonil SR
Clonil SR 75 mg Tablet$ 0.24
Clopic
Clopic 25 mg Tablet$ 0.05
Clopress (New Zealand)
CO Clomipramine (Canada)
Tablet; Oral; Clomipramine Hydrochloride 10 mg

Show all Clomipramine generic names
 
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