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Clophelin

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Clophelin uses and description

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Clophelin - Used for: Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Clophelin is an alpha agonist. It works by relaxing blood vessels and decreasing heart rate, which lowers blood pressure.

Clophelin is an α-adrenergic agent that acts specifically on α-receptor subtypes with similar potency. Its actions in the nervous system decreases blood pressure in patients with hypertension and decreases sympathetic overactivity in patients undergoing opioid withdrawal. Clophelin is also a potent sedative and analgesic and can prevent post-operative shivering in intensive and post-operative care. Its use in differential diagnosis of pheochromocytoma owes to the fact that hypertension in patients with pheochromocytoma is refractory to antihypertensive treatment with clonidine.

Indications:

Adult: PO HTN Initial: 50-100 mcg 3 times/day. Max: 2,400 mcg/day. Menopausal flushing; Migraine prophylaxis 50 mcg twice daily, up to 75 mg twice daily. IV Hypertensive crisis 150-300 mcg via slow inj. Max: 750 mcg over 24 hr. Epidural Severe cancer pain Initial: 30 mcg/hr as continuous infusion in combination w/ an opioid. Transdermal HTN As patch releasing 100-300 mcg Clophelin base/day at constant rate: Apply once wkly.

Oral Hypertension

Adult: Initially, 50-100 mcg tid. As modified-release preparation: 50-100 mcg once or twice daily. Max: 2400 mcg daily.

Child: 2-18 yr: Initially 0.5-1 mcg/kg tid, increase gradually if necessary. Max: 25 mcg/kg daily in divided doses (not exceeding 1.2 mg daily). Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Oral Prophylaxis of migraine

Adult: 50 mcg bid increased to 75 mcg bid if no remission after 2 wk. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose Oral Menopausal flushing

Adult: 50 mcg bid increased to 75 mcg bid if no remission after 2 wk. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose Transdermal Hypertension

Adult: Apply a patch once wkly, delivering 100-300 mcg of Clophelin base daily at a constant rate. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Intravenous Hypertensive crisis

Adult: 150-300 mcg by slow inj over 10-15 min. Max: 750 mcg over 24 hr.

Child: 2-18 yr: 2-6 mcg/kg as a single dose. Max: 300 mcg. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Epidural Severe cancer pain

Adult: Initially, 30 mcg/hr as continuous infusion in combination with an opioid, adjusted according to patient's response.

Oral hypertension

Adult: Initially, 50-100 mcg tid. As modified-release preparation: 50-100 mcg once or twice daily. Max: 2400 mcg daily.

Child: 2–18 yr: Initially 0.5–1 mcg/kg tid, increase gradually if necessary. Max: 25 mcg/kg daily in divided doses (not exceeding 1.2 mg daily). Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Oral Migraine prophylaxis

Adult: 50 mcg bid increased to 75 mcg bid if no remission after 2 wk. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose Oral Menopausal flushing

Adult: 50 mcg bid increased to 75 mcg bid if no remission after 2 wk. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose Intravenous hypertensive crisis

Adult: 150-300 mcg by slow inj over 10-15 min. Max: 750 mcg over 24 hr.

Child: 2–18 yr: 2–6 mcg/kg as a single dose. Max: 300 mcg. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Transdermal hypertension

Adult: Apply a patch once wkly, delivering 100-300 mcg of Clophelin base daily at a constant rate. Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) Dosage Recommendation <10 50-75% of usual dose. Epidural Severe cancer pain

Adult: Initially, 30 mcg/hr as continuous infusion in combination with an opioid, adjusted according to patient's response.

Active ingredients: Clonidine
Unit description, dosagePrice, USD
Injectable; Injection; Clonidine 0.1 mg / ml
Tablet; Oral; Clonidine 0.075 mg
Tablet; Oral; Clonidine 0.15 mg
Drops; Ophthalmic; Clonidine 0.125%
Drops; Ophthalmic; Clonidine 0.25%
Drops; Ophthalmic; Clonidine 0.5%
Tablets; Oral; Clonidine 0.075 mg
Tablets; Oral; Clonidine 0.15 mg

List of clophelin brand and generic drugs

Clonnirit (Israel)
Tablets; Oral; Clonidine Hydrochloride 0.025 mg
Clophelin Luganskiy (Georgia)
Clophelinum (Georgia)
Clophelinum-Darnitsa (Georgia)
Clothalton (India)
Clothalton Clonidine hydrochloride 0.1mg, Chlorthalidone 15 mg. TAB / 10$ 0.74
10's$ 0.74
Clothalton 15 mg+100 mcg Tablet$ 0.07
Dispaclonidin
Dixarit (Bahrain, Belgium, Canada, Cyprus, Egypt, Ethiopia, Hong Kong, Iraq, Ireland, Jordan, Kenya, Kuwait, Lebanon, Libya, Luxembourg, Netherlands, New Zealand, Qatar, Saudi Arabia, South Africa, Sudan, United Arab Emirates, United Kingdom, Yemen)
Tablet; Oral; Clonidine Hydrochloride 0.025 mg
Dixarit 25 mcg x 50's$ 16.05
Tablets; Oral; Clonidine Hydrochloride 0.025 mg
Dom-Clonidine
Tablet; Oral; Clonidine Hydrochloride 0.1 mg
Tablet; Oral; Clonidine Hydrochloride 0.2 mg
Tablets; Oral; Clonidine Hydrochloride 0.1 mg
Tablets; Oral; Clonidine Hydrochloride 0.2 mg
Duraclon (United States)
Injectable; Injection; Clonidine Hydrochloride 0.1 mg / ml
Injectable; Injection; Clonidine Hydrochloride 0.5 mg / ml
10 milliliter in 1 vial
Duraclont
Edolglau (Portugal)
Epiclodina
Glausine
Haemiton (Germany)
Tablet; Oral; Clonidine Hydrochloride 0.075 mg
Tablet; Oral; Clonidine Hydrochloride 0.15 mg
Tablet; Oral; Clonidine Hydrochloride 0.3 mg
Tablets; Oral; Clonidine Hydrochloride 0.075 mg
Tablets; Oral; Clonidine Hydrochloride 0.15 mg
Tablets; Oral; Clonidine Hydrochloride 0.3 mg
Haemiton-Augentropfen
Hypodine (Thailand)
Hypodine 0.075 mg x 10 x 10's
Hypodine 0.15 mg x 10 x 10's
Iporel (Poland)
Ipotensium
Isoglaucon (Austria, Germany, Italy, Spain)
Drops; Ophthalmic; Clonidine Hydrochloride 0.0625%
Drops; Ophthalmic; Clonidine Hydrochloride 0.125%
Drops; Ophthalmic; Clonidine Hydrochloride 0.25%
Jenloga (United States)
Klofelino (Lithuania)
Lowpres (Venezuela)
Menograine (South Africa)
Mirfat
Capsule; Oral; Clonidine Hydrochloride 150 mg
Capsule; Oral; Clonidine Hydrochloride 300 mg

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