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Colchicina

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Colchicina uses and description

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Colchicina - Pharmacology: The exact mechanism of action of Colchicina in gout is not completely known, but it involves a reduction in lactic acid production by leukocytes, which results in a decrease in uric acid deposition, and a reduction in phagocytosis, with abatement of the inflammatory response. In familial Mediterranean fever, Colchicina may interfere with the intracellular assembly of the inflammasome complex present in neutrophils and monocytes that mediates activation of interleukin-1beta. Colchicina disrupts cytoskeletal functions through inhibition of beta-tubulin polymerization into microtubules, and consequently prevents the activation, degranulation, and migration of neutrophils.

Indication: For the prophylaxis and the treatment of acute gout flares when taken at the first sign of a flare; treatment of familial Mediterranean fever ( Colcrys only).

Unlabeled Uses

Treatment of Behçet disease; hepatic cirrhosis; primary biliary cirrhosis; pericarditis; scleroderma; Sweet syndrome; amyloidosis; sarcoid arthritis; acute inflammatory calcific tendonitis; arthritis associated with erythema nodosum; leukemia; adenocarcinoma of the GI tract; mycosis fungoides; topically to treat intraurethral condyloma acuminata in men.

Colchicina affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Because Colchicina was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for Colchicina have been approved by the FDA. As of 2009, Colcrys is the only brand of Colchicina that has been approved by the FDA.

The Colcrys brand of Colchicina is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.

Generic forms of Colchicina have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).

Colchicina is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing. Colchicina should not be used as a routine pain medication for other conditions.

Colchicina may also be used for purposes not listed in this medication guide.

Colchicina is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition.

Colchicina helps to relieve the pain of a sudden gout attack. Colchicina also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina is not a painkiller. It will not be useful for other types of pain.

Oral Acute gout

Adult: Initial dose: 1 mg, reduce to 0.5 mg every 2-3 hr until pain relief is achieved or GI toxicity occurs. Course may be repeated after at least 3 drug-free days. Max dose: 6 mg/course. Renal impairment: Not exceeding 600 mcg daily in patients with CrCl ≤50 ml/min. Oral Prophylaxis of recurrent gouty arthritis

Adult: 0.5-0.6 mg once daily. Up to 1.8 mg daily may be required in some patients. Dosage range: 0.6 mg every other day to 0.6 mg tid. Renal impairment: Not exceeding 600 mcg daily in patients with CrCl ≤50 ml/min. Hepatic impairment: Severe: Contra-indicated. Intravenous Acute gout

Adult: 1 or 2 mg over 2-5 minutes. May give additional doses of 0.5-1 mg every 6 hr up to a total of not more than 4 mg/24 hr. Once the max dose has been reached, further doses should not be given via any route for at least 7 days. Renal impairment: Not to be given to patients undergoing haemodialysis. CrCl (ml/min) Dosage Recommendation 10-50 Reduce dose by 50%. <10 Avoid use. Hepatic impairment: IV dose should be reduced by at least 50%. Incompatibility: 5% dextrose injection, bacteriostatic 0.9% sodium chloride injection.

Indications:

Adult: PO Acute gout Initial: 1 mg, reduce to 0.5 mg 2-3 hrly until pain relief is achieved or GI toxicity occurs. Max: 6 mg/course. May repeat course after at least 3 drug-free days. Prophylaxis of recurrent gouty arthritis 0.5-0.6 mg once daily. IV Acute gout Initial: 1 or 2 mg, then 0.5-1 mg 6 hrly if needed up to 4 mg/24 hr. Once max dose is reached, further doses should not be given via any route for at least 7 days.

Colchicina (Kingdom) helps to relieve the pain of a sudden gout attack. Colchicina (Kingdom) also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina (Kingdom) may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina (Kingdom) is not a painkiller. It will not be useful for other types of pain.

Colchicina (S.T.) helps to relieve the pain of a sudden gout attack. Colchicina (S.T.) also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina (S.T.) may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina (S.T.) is not a painkiller. It will not be useful for other types of pain.

Oral Acute gout

Adult: Initial dose: 1 mg, reduce to 0.5 mg every 2-3 hr until pain relief is achieved or GI toxicity occurs. Course may be repeated after at least 3 drug-free days. Max dose: 6 mg/course. Renal impairment: Not exceeding 600 mcg daily in patients with CrCl ≤50 ml/min. Oral Short-term prophylaxis of gout

Adult: 0.5-0.6 mg given 1-3 times daily. Renal impairment: Not exceeding 600 mcg daily in patients with CrCl ≤50 ml/min. Hepatic impairment: Severe: Contra-indicated. Intravenous Acute gout

Adult: 1 or 2 mg over 2-5 min with additional 0.5-1 mg doses every 6-24 hr as needed. Max: 4 mg/24 hr. Once the max dose has been reached, further doses should not be given via any route for at least 7 days. Renal impairment: Not to be given to patients undergoing haemodialysis. CrCl (ml/min) Dosage Recommendation 10-50 Reduce dose by 50%. <10 Avoid use. Hepatic impairment: IV dose should be reduced by at least 50%. Incompatibility: 5% dextrose injection, bacteriostatic 0.9% sodium chloride injection.

Colchicina (F.Y.) helps to relieve the pain of a sudden gout attack. Colchicina (F.Y.) also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina (F.Y.) may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina (F.Y.) is not a painkiller. It will not be useful for other types of pain.

Colchicina (Shionogi) helps to relieve the pain of a sudden gout attack. Colchicina (Shionogi) also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina (Shionogi) may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina (Shionogi) is not a painkiller. It will not be useful for other types of pain.

Colchicina (Curie) helps to relieve the pain of a sudden gout attack. Colchicina (Curie) also prevents sudden gout attacks and is sometimes given with other gout medicines. Colchicina (Curie) may also be used in the treatment of other medical conditions, as decided by your doctor. Colchicina (Curie) is not a painkiller. It will not be useful for other types of pain.

Active ingredients: Colchicine
Unit description, dosagePrice, USD
Tablet; Oral; Colchicine 0.5 mg
Tablet; Oral; Colchicine

List of colchicina brand and generic drugs

Colchicin Pharbaco (Vietnam)
Colchicin Pharbaco 1 mg x 1 Blister 20 Tablet
Colchicina L.CH. (Chile)
Colchicina Lirca (Italy)
Colchicina Phoenix (Argentina)
Colchicinã (Romania)
Colchicindon (India)
Colchicindon 0.5mg TAB / 10$ 0.22
0.5 mg x 10's$ 0.22
Colchicindon 0.5 mg Tablet$ 0.02
Colchicine (Georgia, Vietnam)
Tablet; Oral; Colchicine Crystallized 1 mg
Tablet; Oral; Colchicine 0.6 mg
Tablet; Oral; Colchicine 1 mg
Tablet; Oral; Colchicine 0.5 mg
Colchicine powder$ 306.60
Colcrys 0.6 mg tablet$ 5.82
Colchicine 0.6 mg tablet$ 0.58
Colchicine 1 mg Tablet$ 0.55
Colchicine (Kingdom) 500 mcg x 500's
Colchicine (Kingdom) 500 mcg x 1000's
Colchicine (Kingdom) 500 mcg x 100 x 10's
Colchicine (Kingdom) 600 mcg x 1000's
Colchicine (S.T.) 0.5 mg x 1000's
Colchicine (S.T.) 0.5 mg x 100 x 10's
Colchicine (F.Y.) 0.5 mg x 1000's
Colchicine (F.Y.) 0.5 mg x 100 x 10's
Colchicine (Shionogi) 0.5 mg x 500's
Colchicine (Shionogi) 0.5 mg x 50 x 10's
Colchicine (Curie) 0.5 mg
Colchicine 1mg (Vietnam)
Colchicine 1mg 1 mg x 1 Blister x 10 Tablet
Colchicine 500 microgram Tablets (United Kingdom)
Colchicine A (Netherlands)
Colchicine Actavis (Netherlands)
Colchicine Asian Pharm (Thailand)
Colchicine Asian Pharm 0.6 mg x 1's
Colchicine Capel (Vietnam)
Colchicine Capel 1 mg x 1 Blister x 20 Tablet
Colchicine Döôïc Ñoâng Nam (Vietnam)
Colchicine Döôïc Ñoâng Nam 1 mg x 2 Blister x 10 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 3 Blister x 10 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 6 Blister x 10 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 10 Blister x 10 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 1 Blister x 20 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 3 Blister x 20 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 5 Blister x 20 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 1 chai 20 Tablet
Colchicine Döôïc Ñoâng Nam 1 mg x 1 chai 60 Tablet

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