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Combiotic

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Combiotic uses and description

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Combiotic consists of Benzylpenicillin, Dihydrostreptomycin, Procaine.

Benzylpenicillin - Combiotic (Benzylpenicillin) is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Combiotic (Benzylpenicillin) has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Combiotic (Benzylpenicillin) is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Indication: For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.

Parenteral Susceptible infections

Adult: 0.6-4.8 g/day in 2-4 divided doses via IM, slow IV inj or infusion, higher doses may be needed in more serious infections. IV doses >1.2 g should be given at a rate of not >300 mg/minute.

Child: 1 mth-12 yr: 100 mg/kg daily in 4 divided doses. Infant 1-4 wk: 75 mg/kg daily in 3 divided doses. Premature infant and neonate up to 7 days old: 50 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Bacterial endocarditis

Adult: 1.2 g every 4 hr by slow inj or infusion, usually used with an aminoglycoside. Renal impairment: Dose adjustments may be necessary. Intravenous Intrapartum prophylaxis against group B Streptoccocal infection in neonates

Adult: Initially, 3 g via IV inj, followed by 1.5 g every 4 hr until delivery.

Child: 150 mg/kg daily in 4 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Meningococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Pneumococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary.

Intravenous Bacterial endocarditis

Adult: 1.2 g every 4 hr by slow inj or infusion, usually used with an aminoglycoside. Renal impairment: Dose adjustments may be necessary. Intravenous Intrapartum prophylaxis against group B Streptoccocal infection in neonates

Adult: Initially, 3 g via IV inj, followed by 1.5 g every 4 hr until delivery.

Child: 150 mg/kg daily in 4 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Meningococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Pneumococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Parenteral Infections due to susceptible organisms

Adult: 0.6-4.8 g/day in 2-4 divided doses via IM, slow IV inj or infusion, higher doses may be needed in more serious infections. IV doses >1.2 g should be given at a rate of not >300 mg/minute.

Child: 1 mth-12 yr: 100 mg/kg daily in 4 divided doses. Infant 1-4 wk: 75 mg/kg daily in 3 divided doses. Premature infant and neonate up to 7 days old: 50 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary.

Dihydrostreptomycin - Indications: gastrointestinal infections

Diarrhea. Causal treatment of gastrointestinal infections or diarrhea of unknown origin, such as colitis or enterocolitis.

Procaine - Combiotic (Procaine) is a local anesthetic. Combiotic (Procaine) causes loss of feeling (numbness) of skin and mucous membranes.

Combiotic (Procaine) is used as an injection during surgery and other medical and dental procedures.

Combiotic (Procaine) may also be used for purposes other than those listed here.

Combiotic (Procaine) is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Combiotic (Procaine) (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Combiotic (Procaine) is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.

Indications:

Adult: Inj Percutaneous infiltration anesth As 0.25 or 0.5% soln: 350-600 mg. Peripheral nerve block As a 0.5, 1 or 2% soln: 0.5-1 g

Injection Percutaneous infiltration anaesthesia

Adult: 350-600 mg using 0.25 or 0.5% solutions. Injection Peripheral nerve block

Adult: 500 mg Combiotic (Procaine) HCl as a 0.5%, 1% or 2% solution. Up to 1 g may be used.

Injection Percutaneous infiltration anaesthesia

Adult: 350-600 mg using 0.25 or 0.5% solutions. Injection Peripheral nerve block

Adult: 500 mg Combiotic (Procaine) HCl as a 0.5%, 1% or 2% solution. Up to 1 g may be used. Special Populations:

Elderly: May require lower concentrations and/or lower dosages of mucosal-local anesthetics, esp for endoscopic procedures.

Active ingredients: Benzylpenicillin/Dihydrostreptomycin/Procaine
Unit description, dosagePrice, USD

List of combiotic brand and generic drugs

Benzylpenicillin/Dihydrostreptomycin/Procaine (Austria)
Cobiotic N (Switzerland)
Interpen-Vet (Austria)
Ogripenstrepto (Austria)
Peni-Strepto (Austria)
Westocillin (Switzerland)
 
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