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Cyclizine

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Cyclizine uses and description

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Cyclizine - Cyclizine is used to relieve nausea, vomiting, and dizziness associated with motion sickness.

Cyclizine may also be used for purposes other than those listed in this medication guide.

Cyclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Cyclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which Cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.

Oral Nausea and vomiting

Adult: As hydrochloride: 50 mg up to tid, up to 200 mg/day. For prevention of motion sickness, 1st dose should be given 30 min before travelling.

Child: 6-12 yr: As hydrochloride: 25 mg up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Treatment and prophylaxis of motion sickness

Adult: As lactate: 50 mg IV/IM every 4-6 hr. 1st dose should be given 30 min before travelling.

Child: As lactate: 25 mg IV/IM up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Prophylaxis of postoperative nausea and vomiting

Adult: As lactate: 50 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 200 mg/24 hr.

Child: 6-12 yr: As lactate: 25 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 50 mg tid. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8.

Cyclizine is used to treat nausea and vomiting. Cyclizine is also used to prevent motion sickness.

Oral Nausea and vomiting

Adult: As hydrochloride: 50 mg up to tid, up to 200 mg/day. For prevention of motion sickness, 1st dose should be given 30 min before travelling.

Child: 6-12 yr: As hydrochloride: 25 mg up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Treatment and prophylaxis of motion sickness

Adult: As lactate: 50 mg IV/IM every 4-6 hr. 1st dose should be given 30 min before travelling.

Child: As lactate: 25 mg IV/IM up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Prophylaxis of postoperative nausea and vomiting

Adult: As lactate: 50 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 200 mg/24 hr.

Child: 6-12 yr: As lactate: 25 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 50 mg tid. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Special Populations: Prevention of motion sickness: Give 30 min before traveling. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8.

Indications:

Adult: PO Nausea and vomiting As HCI: 50 mg up to 3 times/day. To be given 30 mins before travelling for prevention of motion sickness. IV/IM Motion sickness As lactate: 50 mg 4-6 hrly, to be started 30 mins before travelling. Post-op nausea and vomiting As lactate: 50 mg up to 3 times/day, to be started 30 mins pre-op. Max: 200 mg/24 hr.

Oral nausea and vomiting

Adult: As hydrochloride: 50 mg up to tid, up to 200 mg/day. For prevention of motion sickness, 1st dose should be given 30 min before travelling.

Child: 6-12 yr: As hydrochloride: 25 mg up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Prevention and treatment of motion sickness

Adult: As lactate: 50 mg IV/IM every 4-6 hr. 1st dose should be given 30 min before travelling.

Child: As lactate: 25 mg IV/IM up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Parenteral Prevention of postoperative nausea and vomiting

Adult: As lactate: 50 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 200 mg/24 hr.

Child: 6-12 yr: As lactate: 25 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 50 mg tid. Renal impairment: Dose reductions may be needed. Hepatic impairment: Avoid in severe liver disease. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8. Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8.

Active ingredients: Cyclizine
Unit description, dosagePrice, USD

List of cyclizine brand and generic drugs

Aculoid
Adco-Cyclizine (South Africa)
Covamet
Cyclizine HCl CF (Netherlands)
Cyclizine HCl PCH (Netherlands)
Diconal (United Kingdom)
Tablet; Oral; Cyclizine Hydrochloride 30 mg; Dipipanone Hydrochloride 10 mg
DICONAL Drops / 0.1%w/v (10ml units)$ 0.37
0.1 % w/v x 10ml$ 0.37
Diconal 0.1% w/v EYE DPS / 10ml$ 0.37
Diconal Nasal 10 ml Drop$ 0.05
Echnatol (Austria)
Dragee; Oral; Cyclizine Hydrochloride
Emoquil
Fortravel
Happy-Trip
Marazine
Marezine Hydrochloride
Marzine (Denmark, Finland, Norway, Taiwan)
Injectable; Injection; Cyclizine Lactate 50 mg / ml
Marzine 50 mg x 10's$ 5.05
Medazine (South Africa)
Medazine 5 mg x 1's
Medazine 10 mg x 1's
Nautazine
Nauzine (South Africa)
Ne-Devomit
Neo-Devomit
Norizine
Reis-Fit
Reisfit (Netherlands)
Reisziekte (Netherlands)
Ryccard
Triazine (South Africa)
Valoid (Ireland, New Zealand, South Africa, United Kingdom)
Injectable; Injection; Cyclizine Hydrochloride 3.735 mg
Tablet; Oral; Cyclizine Hydrochloride 50 mg
Wellcome (Taiwan)
Wellcome 200 mg
Wellcome 400 mg
Wellcome 400 mg x Blister pk
Wellcome Preparation 47-83
Wellconal (South Africa)
 
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