DURALYN - CR - DURALYN - CR is a bronchodilator. It works by relaxing muscles in the lungs and chest, and makes the lungs less sensitive to allergens and other causes of bronchospasm.
DURALYN - CR is used to treat the symptoms of asthma, bronchitis and emphysema.
DURALYN - CR may also be used for other purposes not listed in this medication guide.
Pharmacology: Relaxes bronchial smooth muscle and stimulates central respiratory drive.
Indication: Prevention or treatment of reversible bronchospasm associated with asthma or COPD.
DURALYN - CR, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. DURALYN - CR has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).
Oral Acute bronchospasm
Adult: As conventional tablet: 5 mg/kg every 6-8 hr.
Child: As conventional tablet: 5 mg/kg every 4-6 hr. Hepatic impairment: Dose adjustment needed. Oral Chronic bronchospasm
Adult: As conventional dosage form: 300-1000 mg in divided doses, every 6-8 hr daily. As modified-release preparations: 175-500 mg every 12 hr. Rate of absorption of modified released preparations varies for different brands.
Child: <2 yr: Not recommended; 2-6 yr: ¼ the adult dose; 20-35 kg (about 6-12 yr old): ½ the adult dose. Rate of absorption of modified released preparations varies for different brands. Hepatic impairment: Dose adjustment needed. Oral Apnoea in infants
Child: Initial dose in neonates: ≤24 days: 1 mg/kg every 12 hr; >24 days: 1.5 mg/kg every 12 hr. Full-term infants: initial daily dosage calculated based on formula, given in 3-4 divided doses: daily dose (mg/kg) = (0.2 X age in wk) + 5.0. If loading dose is needed, 5 mg/kg (or in those already on theophylline, 1 mg/kg for each 2 mcg/ml increase in serum-theophylline concentration). Intravenous Severe bronchospasm
Adult: Patients who are not taking DURALYN - CR or other xanthine medication: 4-5 mg/kg as loading dose by IV infusion over 20-30 minutes followed by
Maintenance: 0.4 mg/kg/hr.
Child: Patients who are not taking DURALYN - CR or other xanthine medication: 4-5 mg/kg as loading dose by IV infusion over 20-30 minutes, followed by maintenance dose: 1-9 yr: 0.8 mg/kg/hr; >9 yr: 0.6-0.7 mg/kg/hr. Hepatic impairment: Dose adjustment needed. Special Populations: Reduce dose in patients with cor pulmonale, heart failure, liver disease and in the elderly. Increase maintenance dose for smokers.
DURALYN - CR is used to treat asthma. DURALYN - CR is known as a "bronchodilator", which literally means "open airways". DURALYN - CR helps to treat your asthma or chest illness by relaxing the airways in your lungs. DURALYN - CR relieves chest tightness, wheezing and cough so that you can breathe more easily.
DURALYN - CR, also known as dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma under a variety of brand names. Due to its numerous side-effects, these drugs are now rarely administered for clinical use. As a member of the xanthine family, it bears structural and pharmacological similarity to caffeine. It is naturally found in tea, although in trace amounts (~1 mg/L), significantly less than therapeutic doses. It is found also in cocoa beans. Amounts as high as 3.7 mg/g have been reported in Criollo cocoa beans.
Adult: PO Acute bronchospasm 5 mg/kg 6-8 hrly. Chronic bronchospasm 300-1,000 mg in divided doses 6-8 hrly. Extended release 175-500 mg 12 hrly. IV Severe bronchospasm Patients who are not taking DURALYN - CR or other xanthine medication: Loading dose: 4-5 mg/kg via infusion, then 0.4 mg/kg/hr.
Indications: Reversible airway obstructive diseases.