Depakote - Divalproex is a stable co-ordination compound comprised of sodium valproate and Depakote in a 1:1 molar relationship and formed during the partial neutralization of Depakote with 0.5 equivalent of sodium hydroxide. Divalproex is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, divalproex is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. Divalproex is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Divalproex dissociates to the valproate ion in the gastrointestinal tract.
Indication: For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache.
Divalproex sodium affects chemicals in the body that may be involved in causing seizures.
Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications.
Divalproex sodium may also be used for other purposes not listed in this medication guide.
Divalproex sodium consists of a compound of sodium valproate and Depakote in a 1:1 molar relationship in an enteric coated form. It is used in the UK, Canada, and U.S. for the treatment of the manic episodes of bipolar disorder. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevention of both manic and depressive phases of bipolar disorder, especially the rapid-cycling variant. It is also used in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis(2-propylpentanoate). The extended release formulation allows for a single daily dose.
In the UK semisodium valproate has been sold for a few years as the proprietary drug Depakote and marketed for psychiatric conditions only. It is about five times the price of sodium valproate, which has been marketed for around 30 years as Epilim by the same company for epilepsy and is also available from other manufacturers as a generic product.
Indications: bipolar disorder, epilepsy, migraine
Primary generalised seizures, Partial seizures, Acute manic episodes of bipolar disorder, Prophylaxis of migraine.
Epilepsy Depakote Sprinkle Capsules are indicated as monotherapyand adjunctive therapy in the treatment of adult patients and pediatricpatients down to the age of 10 years with complex partial seizuresthat occur either in isolation or in association with other typesof seizures. Depakote Sprinkle Capsules are also indicated for useas sole and adjunctive therapy in the treatment of simple and complexabsence seizures, and adjunctively in patients with multiple seizuretypes that include absence seizures. Simpleabsence is defined as very brief clouding of the sensorium or lossof consciousness accompanied by certain generalized epileptic dischargeswithout other detectable clinical signs. Complex absence is the termused when other signs are also present. [see Warnings and Precautions (5.2), Patient Counseling Information (17.3) ]
Indications: Absence seizures.
Adjuvant drug for - Grandmal epilepsy.
Simple partial seizures.
Complex partial seizures.
Myoclonic and atonic seizures.
Mania and bipolar illness.
Prophylactic drug in migraine.