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Depo-Medrol

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Depo-Medrol uses and description

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Depo-Medrol - Depo-Medrol is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Depo-Medrol is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

Indication: For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogues may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia. Nonsuppressive thyroiditis. Hypercalcaemia associated with cancer. Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogues are used). Preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. Congenital adrenal hyperplasia, nonsuppurative thyroiditis, hypercalcemia associated with cancer. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). Ankylosing spondylitis. Acute and subacute bursitis. Synovitis of osteoarthritis. Acute nonspecific tenosynovitis. Post-traumatic osteoarthritis. Psoriatic arthritis. Epicondylitis. Acute gouty arthritis. Collagen Diseases (Immune and Complex Diseases): During an exacerbation or as a maintenance therapy in selected cases of systemic lupus erythematosus (and lupus nephritis for Solu-Medrol), systemic dermatomyositis (polymyositis), acute rheumatic carditis. Solu-Medrol is also indicated for polyarteritis nodosa and Good pasture's syndrome. Dermatologic Diseases: Bullous dermatitis herpetiformis, severe erythema multiforme (Stevens-Johnson syndrome), severe seborrheic dermatitis, exfoliative dermatitis, mycosis fungoides, pemphigus, severe psoriasis. Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis, drug hypersensitivity reactions, serum sickness, contact dermatitis, bronchial asthma, atopic dermatitis. Depo-Medrol/Solu-Medrol is also indicated for urticarial transfusion reactions, acute non-infectious laryngeal edema (epinephrine is the 1st drug of choice). Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, eg allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, keratitis, optic neuritis, allergic conjunctivitis, chorioretinitis, iritis and iridocyclitis. Respiratory Diseases: Symptomatic sarcoidosis. Berylliosis. Loeffler's syndrome not manageable by other means. Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy. Aspiration pneumonitis. Hematologic Disorders: Secondary thrombocytopenia in adults. Acquired (autoimmune) hemolytic anemia. Erythroblastopenia (RBC anemia). Congenital (erythroid) hypoplastic anemia. Medrol/Solu-Medrol is indicated for idiopathic thrombocytopenic purpura in adults (IV only; IM administration is contraindicated for Solu-Medrol). Neoplastic Diseases: For palliative management of leukemias and lymphomas in adults and acute leukemia in children. Solu-Medrol is indicated for terminal cancer: To improve quality of life in patients with terminal cancer. Edematous States: To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. Gastrointestinal Diseases: To tide the patient over a critical period of the disease in ulcerative colitis and regional enteritis. Depo-Medrol/Solu-Medrol is indicated for systemic therapy. Nervous System: Acute exacerbations of multiple sclerosis. Solu-Medrol is indicated for cerebral edema from tumor - primary or metastatic and/or associated with surgical or radiation therapy or head trauma. Cardiovascular Conditions (for Solu-Medrol only): Shock secondary to adrenocortical insufficiency or shock unresponsive to conventional therapy when adrenal cortical insufficiency may be present. (Hydrocortisone is generally the drug of choice. When mineralocorticoid activity is undesirable, Depo-Medrol may be preferred.) Although there are no well-controlled (double-blind placebo) clinical trials, data from experimental animal models indicate that Solu-Medrol may be useful in hemorrhagic, traumatic and surgical shock unresponsive to standard therapy (eg, fluid replacement, etc). Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement. Organ Transplantation (Solu-Medrol only): Prevention of nausea and vomiting associated with cancer chemotherapy. Depo-Medrol: IM Administration: When oral therapy is not feasible and the strength, dosage form and route of administration of the drug reasonably led the preparation to the treatment of the condition, the IM use of Depo-Medrol is indicated. Intrasynovial or Soft Tissue Administration Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogues are used.) Congenital adrenal hyperplasia. Hypercalcemia associated with cancer. Nonsuppurative thyroiditis. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Post-traumatic osteoarthritis ; synovitis of osteoarthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); acute and subacute bursitis ; epicondylitis; acute nonspecific tenosynovitis ; acute gouty arthritis ; psoriatic arthritis; ankylosing spondylitis. Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus ; systemic dermatomyositis (polymyositis); acute rheumatic carditis. Dermatologic Diseases: Pemphigus ; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis ; mycosis fungoides ; bullous dermatitis herpetiformis ; severe seborrheic dermatitis ; severe psoriasis. Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in: Bronchial asthma ; contact dermatitis ; atopic dermatitis ; serum sickness ; seasonal or perennial allergic rhinitis ; drug hypersensitivity reactions; urticarial transfusion reactions; acute noninfectious laryngeal edema (epinephrine is the drug of 1st choice). Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye eg, herpes zoster ophthalmicus; iritis, iridocyclitis ; chorioretinitis; diffuse posterior uveitis ; optic neuritis ; drug hypersensitivity reactions; anterior segment inflammation; allergic conjunctivitis ; allergic corneal marginal ulcers; keratitis. Gastrointestinal Diseases: To tide the patient over a critical period of the diseases in: Ulcerative colitis (systemic therapy); regional enteritis (systemic therapy). Respiratory Diseases: Symptomatic pulmonary sarcoidosis ; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; Loeffler's syndrome not manageable by other means; aspiration pneumonitis. Hematologic Disorders: Acquired (autoimmune) hemolytic anemia ; secondary thrombocytopenia in adults; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia. Neoplastic Diseases: For palliative management of leukemias and lymphomas; acute leukemia of childhood. Edematous States: To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. Nervous System: Acute exacerbations of multiple sclerosis. Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement. For Intrasynovial or Soft Tissue Administration (including periarticular and intrabursal). Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogues are used). Congenital adrenal hyperplasia. Hypercalcemia associated with cancer. Nonsuppurative thyroiditis. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in post-traumatic osteoarthritis; synovitis of osteoarthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); epicondylitis; acute nonspecific tenosynovitis; acute gouty arthritis; psoriatic arthritis; ankylosing spondylitis; acute and subacute bursitis. Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases of systemic lupus erythematosus; systemic dermatomyositis (polymyositis); acute rheumatic carditis. Dermatologic Diseases: Pemphigus; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; bullous dermatitis herpetiformis; severe seborrheic dermatitis; severe psoriasis; mycosis fungoides. Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in: Bronchial asthma, contact dermatitis; atopic dermatitis; serum sickness; seasonal or perennial allergic rhinitis; drug hypersensitivity reactions; urticarial transfusion reactions; acute non-infectious laryngeal edema (epinephrine is the drug of choice). Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye eg, herpes zoster ophthalmicus; iritis, iridocyclitis; chorioretinitis; diffuse posterior uveitis; optic neuritis; drug hypersensitivity reactions; anterior segment inflammation; allergic conjunctivitis; allergic corneal, marginal ulcers; and keratitis. Gastrointestinal Diseases: To tide the patient over a critical period of the diseases in ulcerative colitis (systemic therapy); regional enteritis (systemic therapy). Respiratory Diseases: Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; Loeffler's syndrome not manageable by other means; symptomatic sarcoidosis; berylliosis; aspiration pneumonitis. Haematologic Disorders: Acquired (autoimmune) hemolytic anemia; secondary thrombocytopenia in adults; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia. Neoplastic Diseases: For palliative management of leukaemias and lymphomas; acute leukaemia of childhood. Edematous States: To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. Nervous System: Acute exacerbations of multiple sclerosis. Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement. Intrasynovial or Soft Tissue Administration (including periarticular and intrabursal) (see Warnings): Adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Synovitis of osteoarthritis, rheumatoid arthritis, post-traumatic osteoarthritis, epicondylitis, acute nonspecific tenosynovitis, acute and subacute bursitis, acute gouty arthritis. Intralesional Administration: Depo-Medrol is indicated for intralesional use in the following conditions: Keloids; localized hypertrophic, infiltrated, inflammatory lesions of lichen planus, psoriatic plaques; granuloma annulare; lichen simplex chronicus (neurodermatitis); discoid lupus erythematosus; necrobiosis lipodica diabeticorum; alopecia areata. Depo-Medrol may also be useful in cystic tumors or an aponeurosis of tendon (ganglia).

Indications: corticosteroid

Depo-Medrol is in a class of drugs called steroids. It prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Prednisolone is the active metabolite of prednisone. Prednisolone is a corticosteroid drug with predominantly glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, uveitis, rheumatoid arthritis, ulcerative colitis, temporal arteritis and Crohn's disease, Bell's palsy, multiple sclerosis, cluster headaches, systemic lupus erythematosus, acute lymphoblastic leukemia and autoimmune hepatitis and dermatomyositis.

Depo-Medrol is a synthetic glucocorticoid drug. It is sold in the USA and Canada under the brand names Medrol, Solu-Medrol and Cadista. It is also available as a generic drug.

It is a variant of prednisolone, methylated at carbon 6 of the B ring.

Active ingredients: Methylprednisolone
Unit description, dosagePrice, USD
Injectable; Injection; Methylprednisolone Acetate 20 mg / ml
Injectable; Injection; Methylprednisolone Acetate 40 mg / ml
Injectable; Injection; Methylprednisolone Acetate 80 mg / ml
Depo-Medrol 40 mg/1 mL x 1 mL
Depo-Medrol (vial) 40 mg/1 mL x 1's$ 7.51
Depo-Medrol 40 mg/1 mL x 1 loï
Depo-Medrol 200 mg/5 mL x 1's
Depo-Medrol 40 mg/1 mL x 5 mL
Depo-Medrol with Lidocaine 1 mL
40 mg x 1 mL x 2ml$ 1.20
Depo-Medrol 40 mg/1 mL x 1 mL x 1's$ 8.52
Depo-Medrol 40mg x 1mL INJ / 2ml$ 1.20

List of depo-medrol brand and generic drugs

Depo-Medrate (Germany)
Depo-Medrol Veterinary
Injectable; Injection; Methylprednisolone Acetate 20 mg / ml
Injectable; Injection; Methylprednisolone Acetate 40 mg / ml
Depo-Melcort (Japan)
Depo-Nisolone (Australia)
Injectable; Injection; Methylprednisolone Acetate 40 mg / ml
Depo-Predate
Depocoid
Injectable; Injection; Methylprednisolone Acetate 40 mg / ml
Depoject
Depomax (India)
Depomax 1g INJ / 1$ 17.59
1 g x 1's$ 17.59
Depomax 1000 mg Injection$ 17.59
Depomax S
Depomax S 40 mg Injection$ 2.22
Depomed (Bangladesh)
Depomedrol (Venezuela)
Injectable; Injection; Methylprednisolone Acetate 40 mg / ml
Depopred (India)
40 mg x 1 mL x 1ml$ 0.33
40 mg x 1 mL x 2ml$ 0.48
Depopred 40mg x 1mL VIAL / 1ml$ 0.33
Depopred 40mg x 1mL VIAL / 2ml$ 0.48
DEPOTEX (India)
4 mg x 10's$ 0.76
16 mg x 10's$ 2.39
Depotex 4mg TAB / 10$ 0.76
Depotex 16mg TAB / 10$ 2.39
Depotex 16 mg Tablet$ 0.24
Depotex 4 mg Tablet$ 0.08
Depredil (Australia)
DIPRED (India)
4 mg x 10's$ 0.85
16 mg x 10's$ 2.70
Dipred 4mg TAB / 10$ 0.85
Dipred 16mg TAB / 10$ 2.70
Dipred 125 mg Injection$ 3.63
Dipred 40 mg Injection$ 1.81
Dipred 1000 mg Injection$ 17.19
DISPRED (India)
4 mg x 10's$ 0.70
16 mg x 10's$ 2.67
Dispred 4mg DISPERTAB / 10$ 0.70
Dispred 16MG DISPERTAB / 10$ 2.67
Dispred Eye Drop$ 0.11
Dopomedrol
Duralone
E-Cort
E-Cort 4mg TAB / 10
E-Cort 16mg TAB / 10
Elopred
Elopred 4mg TAB / 10$ 0.83

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