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Dolforin

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Dolforin uses and description

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Dolforin - Used for: Producing anesthesia for surgery and treating pain before, during, and after surgery. It may also be used with other medicines.

Dolforin is a narcotic (opioid) analgesic. It works in the brain and nervous system to cause anesthesia and decrease pain.

Dolforin is an opioid analgesic. Dolforin interacts predominately with the opioid mu-receptor but also binds to kappa and delta-type opioid receptors. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Dolforin exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Dolforin may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Dolforin depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.

Indications:

Adult: PO Breakthrough cancer pain As a loz: Initially, 200 mcg over 15 minutes for an episode of breakthrough pain; may repeat once after 15 minutes if needed. Not more than 4 unit doses/day. IV Adjunct to general anesth Patients w/ spontaneous resp: Initial: 50-200 mcg, w/ supplements of 50 mcg. Patients w/ assisted ventilation: Initial: 300-3,500 mcg (up to 50 mcg/kg), w/ supplements of 100-200 mcg depending on response. IM Premed before anesth 50-100 mcg 30-60 mins before induction of anesth. Transdermal Intractable cancer pain Initial: Apply patch that delivers ≤25 mcg/hr of Dolforin in opioid-naive patients. Adjust dose according to response. For patients who have been receiving a strong opioid, initial dose should be based on the previous 24-hr opioid requirement. Replace patch 72 hrly and apply new patch to a different site.

Oral Breakthrough cancer pain

Adult: For patients who are already receiving and tolerant to opioid treatment: As a loz: Initially, 200 mcg over 15 minutes for an episode of breakthrough pain; may repeat once after 15 minutes if needed. Titrate subsequent doses based on response up to 1.6 mg per dose. Once the effective dose has been identified, no more than 4 unit doses should be taken daily.

Elderly: and debilitated patients: Dose reduction may be needed. Intravenous Adjunct to general anaesthesia

Adult: For patients with spontaneous respiration: Initially, 50-200 mcg followed by supplements of 50 mcg. To be injected over 3-5 minutes. Possible increased risk of resp depression following doses >200 mcg. For patients with assisted ventilation: Initially, 300-3,500 mcg (up to 50 mcg/kg) followed by supplements of 100-200 mcg depending on the patient's response. To be injected over 3-5 minutes.

Child: For patients with spontaneous respiration: >2 yr: 3-5 mcg/kg IV, supplements of 1 mcg/kg may be given. For patients with assisted ventilation: >2 yr: Initially, 15 mcg/kg with supplements of 1-3 mcg/kg.

Elderly: and debilitated patients: Dose reduction may be needed. Transdermal Intractable chronic pain

Adult: Patches deliver Dolforin in doses that range from 12-100 mcg/hr. Doses should be individually titrated based on previous use of opioids. For opioid-naive patients: Initiate with patches that deliver not more than 25 mcg/hr of fentanyl. Recommended for opioid-naive patients to start with low doses of short-acting opioids before starting on Dolforin patches. For patients who have been receiving a strong opioid, the initial dose should be based on the previous 24-hr opioid requirement. During transfer to Dolforin patches, previous opioid treatment should be phased out gradually. If patient requires doses >100 mcg/hr, >1 patch may be used; consider alternative or additional therapy if doses >300 mcg/hr are required. Replace patch every 72 hr and apply the new patch to a different site; avoid using the same area of skin for a few days.

Elderly: and debilitated patients: Dose reduction may be needed. Intramuscular Premedication before anaesthesia

Adult: 50-100 mcg, to be given 30-60 minutes before induction of anaesthesia.

Elderly: and debilitated patients: Dose reduction may be needed. Incompatibility: Thiopental sodium and methohexital sodium.

For use as a narcotic analgesic supplement in general or regional anaesthesia, for administration with a neuroleptic eg, droperidol as an anaesthetic premedication, for the induction of anaesthesia, and as an adjunct in the maintenance of general and regional anaesthesia, for use an anaesthetic agent with oxygen in selected high-risk patients undergoing major surgery.

Oral Breakthrough cancer pain

Adult: For patients who are already receiving and tolerant to opioid treatment: As a loz: Initially, 200 mcg over 15 minutes for an episode of breakthrough pain; may repeat once after 15 minutes if needed. Titrate subsequent doses based on response up to 1.6 mg per dose. Once the effective dose has been identified, no more than 4 unit doses should be taken daily.

Elderly: and debilitated patients: Dose reduction may be needed. Intravenous Adjunct to general anaesthesia

Adult: For patients with spontaneous respiration: Initially, 50-200 mcg followed by supplements of 50 mcg. To be injected over 3-5 minutes. Possible increased risk of resp depression following doses >200 mcg. For patients with assisted ventilation: Initially, 300-3,500 mcg (up to 50 mcg/kg) followed by supplements of 100-200 mcg depending on the patient's response. To be injected over 3-5 minutes.

Child: For patients with spontaneous respiration: >2 yr: 3-5 mcg/kg IV, supplements of 1 mcg/kg may be given. For patients with assisted ventilation: >2 yr: Initially, 15 mcg/kg with supplements of 1-3 mcg/kg.

Elderly: and debilitated patients: Dose reduction may be needed. Transdermal Intractable chronic pain

Adult: Patches deliver Dolforin in doses that range from 12-100 mcg/hr. Doses should be individually titrated based on previous use of opioids. For opioid-naive patients: Initiate with patches that deliver not more than 25 mcg/hr of fentanyl. Recommended for opioid-naive patients to start with low doses of short-acting opioids before starting on Dolforin patches. For patients who have been receiving a strong opioid, the initial dose should be based on the previous 24-hr opioid requirement. During transfer to Dolforin patches, previous opioid treatment should be phased out gradually. If patient requires doses >100 mcg/hr, >1 patch may be used; consider alternative or additional therapy if doses >300 mcg/hr are required. Replace patch every 72 hr and apply the new patch to a different site; avoid using the same area of skin for a few days.

Elderly: and debilitated patients: Dose reduction may be needed. Intramuscular Premedication before anaesthesia

Adult: 50-100 mcg, to be given 30-60 minutes before induction of anaesthesia.

Elderly: and debilitated patients: Dose reduction may be needed. Special Populations: Reduce dose in elderly and debilitated patients. Incompatibility: Thiopental sodium and methohexital sodium.

Intravenous As an adjunct to general anaesthesia in patients with spontaneous respiration

Adult: Initially, 50-200 mcg followed by supplements of 50 mcg. To be injected over 3-5 minutes.

Child: >2 yr: 3-5 mcg/kg IV, supplements of 1 mcg/kg may be given.

Elderly: and debilitated patients: Dose reduction may be needed. Intravenous As an adjunct to general anaesthesia in patients with assisted ventilation

Adult: Initially, 300-3500 mcg (up to 50 mcg/kg) followed by supplements of 100-200 mcg depending on the patient's response. To be injected over 3-5 minutes.

Child: >2 yr: Initially, 15 mcg/kg with supplements of 1-3 mcg/kg.

Elderly: and debilitated patients: Dose reduction may be needed. Max

Dosage: 50 mcg/kg. Intramuscular Anaesthetic premedication

Adult: 50-100 mcg, to be given 30-60 minutes before induction of anaesthesia.

Elderly: and debilitated patients: Dose reduction may be needed. Transdermal Intractable chronic cancer pain in patients receiving strong opioid analgesic

Adult: Patches deliver Dolforin in doses that range from 12-100 mcg/hr. For opioid-naive patients: Initiate with patches that deliver not more than 25 mcg/hr of fentanyl. Recommended for opioid-naive patients to start with low doses of short-acting opioids before starting on Dolforin patches. For patients who have been receiving strong opioid, the initial dose should be based on the previous 24-hr opioid requirement. During transfer to Dolforin patches, previous opioid treatment should be phased out gradually. >1 patch may be used if doses >100 mcg/hr are required. Replace patch every 72 hr and apply the new patch at a different site. The same area of skin should be avoided for a few days.

Elderly: and debilitated patients: Dose reduction may be needed. Incompatibility: Thiopental sodium and methohexital sodium.

Active ingredients: Fentanyl
Unit description, dosagePrice, USD

List of dolforin brand and generic drugs

Demogyl (Greece)
Duragesic (Canada, United States)
Film, Extended Release; Transdermal; Fentanyl 12.5 mcg / hr
Film, Extended Release; Transdermal; Fentanyl 25 mcg / hr
Film, Extended Release; Transdermal; Fentanyl 50 mcg / hr
Film, Extended Release; Transdermal; Fentanyl 75 mcg / hr
Film, Extended Release; Transdermal; Fentanyl 100 mcg / hr
Duragesic 12
Patch; Transdermal; Fentanyl 12 mcg
Duragesic MAT
Patch; Transdermal; Fentanyl 100 mcg / h
Patch; Transdermal; Fentanyl 25 mcg / h
Patch; Transdermal; Fentanyl 50 mcg / h
Patch; Transdermal; Fentanyl 75 mcg / h
Duragesic-100
Durodor (Mexico)
Durogesic (Indonesia)
Patch; Topical; Fentanyl 12.5 mcg / h
Patch; Topical; Fentanyl 25 mcg / h
Patch; Topical; Fentanyl 50 mcg / h
Patch; Topical; Fentanyl 75 mcg / h
Patch; Topical; Fentanyl 100 mcg / h
Durogesic 12 mcg/1 hr x 5's
Durogesic 25 mcg/1 hr x 5's$ 123.25
Durogesic 50 mcg/1 hr x 5's$ 222.93
Durogesic 12mcg/hr T-PATCH / 1$ 4.93
Durogesic 25mcg/hr T-PATCH / 1$ 9.17
Durogesic 50mcg/hr T-PATCH / 1$ 17.65
Durogesic 75mcg/hr T-PATCH / 1
Durogesic 100mcg/hr T-PATCH / 1
Durogesic 75 mcg/1 hr x 5's
Durogesic 100 mcg/1 hr x 5's
Durogesic 12 mcg/1 hr x 5
Durogesic 25 mcg/1 hr x 5
Durogesic 50 mcg/1 hr x 5
12 mcg x 1 hr x 1's$ 4.93
25 mcg x 1 hr x 1's$ 9.17
50 mcg x 1 hr x 1's$ 17.65
75 mcg x 1 hr x 1's
100 mcg x 1 hr x 1's
Durogesic 2.1 mg x 5's
Durogesic 4.2 mg x 5's
Durogesic 8.4 mg x 5's
Durogesic 25 mcg Patch$ 0.02
Durogesic 50 mcg Patch$ 0.04
Durogesic 100 mcg Patch$ 0.06
Durogesic 12 mcg Patch$ 4.93
Durogesic 12mcg/hr T-PATCH / 1hr$ 4.93
Durogesic 25mcg/hr T-PATCH / 1hr$ 27.50
Durogesic 50mcg/hr T-PATCH / 1hr$ 17.65
Durogesic 75mcg/hr T-PATCH / 1hr
Durogesic 100mcg/hr T-PATCH / 1hr
Durogesic D-Trans (Taiwan)
Patch; Topical; Fentanyl 12.5 mcg / h
Patch; Topical; Fentanyl 25 mcg / h
Patch; Topical; Fentanyl 50 mcg / h
Patch; Topical; Fentanyl 75 mcg / h
Patch; Topical; Fentanyl 100 mcg / h
Durogesic D-TRANS 12.5 mcg/1 hr x 5's
Durogesic D-TRANS 25 mcg/1 hr x 5's$ 1300.00
Durogesic D-TRANS 50 mcg/1 hr x 5's$ 2250.00
Durogesic D-TRANS 75 mcg/1 hr x 5's
Durogesic D-TRANS 100 mcg/1 hr x 5's
Durogesic D-Trans 12 mcg/1 hr x 5's$ 885.00
Durogesic dtrans (Ireland)
Patch; Topical; Fentanyl 12.5 mcg / h
Patch; Topical; Fentanyl 25 mcg / h
Patch; Topical; Fentanyl 50 mcg / h
Patch; Topical; Fentanyl 75 mcg / h
Patch; Topical; Fentanyl 100 mcg / h
Durogesic Matrix (Spain)
Patch; Topical; Fentanyl 12.5 mcg / h

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