Duloxetine - Duloxetine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Duloxetine affects chemicals in the brain that may become unbalanced and cause depression.
Duloxetine is used to treat major depressive disorder and general anxiety disorder.
Duloxetine is also used to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).
Duloxetine is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy).
Duloxetine may also be used for purposes not listed in this medication guide.
Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Known also as LY248686, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system.
Duloxetine is used to treat depression and anxiety. It is also used to treat nerve pain in people who have diabetes. Duloxetine has also been used to control the bladder in women who have urinary incontinence.
Adult: 20-30 mg bid or 60 mg once daily. Max: 60 mg daily. Renal impairment: CrCl ≥30 ml/min: No adjustment needed. Avoid use in severe impairment. Oral Diabetic neuropathy
Adult: 60 mg once daily. Max: 120 mg daily. Renal impairment: CrCl ≥30 ml/min: No adjustment needed. Avoid use in severe impairment. Oral Moderate to severe stress urinary incontinence in women
Adult: 40 mg bid. Renal impairment: CrCl ≥30 ml/min: No adjustment needed. Avoid use in severe impairment. Special Populations: In renal impairment, lower starting dose and consider gradual increase in dose.
Adult: PO Depression 20-30 mg twice daily. Max: 60 mg/day. Diabetic neuropathy 60 mg once daily. Max: 120 mg/day. Moderate to severe stress incontinence in women 40 mg twice daily.