**Epoetin Alfa** - Parenteral Anaemia of chronic renal failure
Adult: In predialysis and haemodialysis: Initially, 50 iu/kg 3 times a wk as SC/IV Inj over at least 1 minute or as slow IV Inj over 5 minutes in patients who experience flu-like symptoms as side effects. Doses may be increased by 25 units/kg at 4-wk intervals until the target is reached. In peritoneal dialysis: Initially, 50 units/kg SC twice a wk. Total wkly maintenance dose: Predialysis: 50-100 units/kg in 3 divided doses. Haemodialysis: 75-300 units/kg in 3 divided doses. Peritoneal dialysis: 50-100 units/kg IV in 2 divided doses.
Child: Haemodialysis: Initially, 50 units/kg given IV 3 times a wk. May be increased by 25 units/kg at 4-wk intervals until the target Hb conc is reached (9.5-11 g/mL). Total wkly maintenance dose: Haemodialysis: >30 kg: 90-300 units/kg; 10-30 kg: 180-450 units/kg; <10 kg: 225-450 units/kg. To be given in 3 divided doses. Parenteral Anaemia in zidovudine-treated HIV-infected patients
Adult: Titrate dose for patients individually so as to achieve and maintain the lowest haemoglobin level sufficient to avoid the need for blood transfusion and not to exceed 12 g/dL. For patients with serum erythropoietin levels ≤500 mUnits/mL who are receiving zidovudine dose ≤4200 mg/wk: Starting dose: 100 units/kg via SC/IV Inj 3 times a wk for 8 wk, may increase by 50-100 units/kg 3 times a wk at 4-8 wk intervals according to response. Not recommended to administer doses >300 units/kg 3 times a wk. Intravenous Increase yield of autologous blood
Adult: 600 units/kg 2 times a wk starting 3 wk before surgery. May be used in conjunction with an iron supplement. Subcutaneous Anaemia related to non-myeloid malignant disease chemotherapy
Adult: Initially, 150 units/kg 3 times a wk or 450 units/kg once wkly, increased after 4-8 wk to 300 units/kg 3 times a wk if necessary. Stop treatment if response is still inadequate after 4 wk of treatment at this higher dose. Subcutaneous To reduce the need for allogeneic blood transfusion
Adult: 600 units/kg once wkly starting 3 wk before surgery with the 4th dose given on the day of the surgery or 300 units/kg daily starting 10 days before surgery and for 4 days after.
Indications:
Adult: IV Increase yield of autologous blood 600 u/kg twice wkly starting 3 wk before surgery. IV/SC Anaemia of chronic renal failure Predialysis and haemodialysis: Initial: 50 iu/kg 3 times/wk. May increase slowly. Peritoneal dialysis: Initial: 50 u/kg twice wkly. Total maintenance dose/wk: Predialysis: 50-100 u/kg in 3 divided doses; Haemodialysis: 75-300 u/kg in 3 divided doses; Peritoneal dialysis: 50-100 u/kg in 2 divided doses. Anaemia in zidovudine-treated HIV-infected patients Initial: 100 u/kg 3 times/wk for 8 wk. May increase slowly. Not >300 u/kg 3 times/wk. SC Anemia related to non-myeloid malignant disease chemotherapy Initial: 150 u/kg 3 times/wk, up to 300 u/kg 3 times/wk after 4-8 wk if needed. To reduce the need for allogenic blood tranfusion 600 u/kg once wkly starting 3 wk before surgery w/ the 4th dose given on the day of surgery.
Intravenous Increase yield of autologous blood
Adult: 600 units/kg 2 times a wk starting 3 wk before surgery. May be used in conjunction with an iron supplement. Subcutaneous Anemia related to non-myeloid malignant disease chemotherapy
Adult: Initially, 150 units/kg 3 times a wk or 450 units/kg once wkly, increased after 4-8 wk to 300 units/kg 3 times a wk if necessary. Stop treatment if response is still inadequate after 4 wk of treatment at this higher dose. Subcutaneous Reduce the need for allogeneic blood transfusion
Adult: 600 units/kg once wkly starting 3 wk before surgery with the 4th dose given on the day of the surgery or 300 units/kg daily starting 10 days before surgery and for 4 days after. Parenteral anaemia of chronic renal failure
Adult: In predialysis and haemodialysis: Initially, 50 iu/kg 3 times a wk as SC/IV Inj over at least 1 minute or as slow IV Inj over 5 minutes in patients who experience flu-like symptoms as side effects. Doses may be increased by 25 units/kg at 4-wk intervals until the target is reached. In peritoneal dialysis: Initially, 50 units/kg SC twice a wk. Total wkly maintenance dose: Predialysis: 50-100 units/kg in 3 divided doses. Haemodialysis: 75-300 units/kg in 3 divided doses. Peritoneal dialysis: 50-100 units/kg IV in 2 divided doses.
Child: Haemodialysis: Initially, 50 units/kg given IV 3 times a wk. May be increased by 25 units/kg at 4-wk intervals until the target Hb conc is reached (9.5-11 g/mL). Total wkly maintenance dose: Haemodialysis: >30 kg: 90-300 units/kg; 10-30 kg: 180-450 units/kg; <10 kg: 225-450 units/kg. To be given in 3 divided doses. Parenteral anaemia in HIV-positive patients on zidovudine therapy
Adult: Initially, 100 units/kg SC/IV Inj 3 times a wk for 8 wk, may increase by 50-100 units/kg at 4-8 wk intervals. Max: 300 units/kg 3 times a wk. |