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Fental

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Fental uses and description

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Fental - Fental is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antineoplastic activity by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that nitazoxanide inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), all folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Fental is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, nitazoxanide is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, to a lesser extent, in normal tissues. Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.

Indication: For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia and for the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum.

Indications: allergic eye disorders

Active ingredients: Fentanyl
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List of fental brand and generic drugs

Fentahexal (Czech Republic, Poland)
Fentalgon (Italy)
Fentalis (United Kingdom)
Fentamat (Bulgaria)
FentaMat Sandoz (Germany)
Fentamed (Austria)
Fentanest (Brazil, Italy, Japan, Mexico, Spain)
Injectable; Injection; Fentanyl Citrate 0.05 mg / ml
Fentanil Hexal (Italy)
Fentanil M Lek (Bosnia & Herzegowina)
Fentanil R Lek (Bosnia & Herzegowina)
Fentanil ratiopharm (Italy)
Fentanil Sandoz (Italy)
Fentanil Winthrop (Italy)
Fentanila
Injectable; Injection; Fentanyl Citrate 0.05 mg / ml
Fentanila Biosano (Chile)
Fentanila Citrato (Chile)
Fentanilis Sanitas (Lithuania)
Fentanilo (Chile, Venezuela)
Injectable; Injection; Fentanyl Citrate 0.05 mg / ml
Fentanilo Acost (Spain)
Fentanilo Acostgen (Spain)
Fentanilo Acostlabs (Spain)
Fentanilo Bexal (Spain)
Fentanilo Citrato (Argentina)
Fentanilo Denver Farma (Argentina)
Fentanilo Dosa (Argentina)
Fentanilo Fabra (Argentina)
Fentanilo Gemepe (Argentina)
Fentanilo Gray (Argentina)
Fentanilo Kilab (Argentina)
Fentanilo Lazar (Argentina)
Fentanilo Matrix Ratiomed (Spain)
Fentanilo Matrix Ratiopharm (Spain)
Fentanilo Matrix Sandoz (Spain)
Fentanilo Matrix Winthrop (Spain)
Fentanilo Northia (Argentina)
Fentanilo Pharma Genexx (Chile)
Fentanilo Sanderson (Peru)
Fentanilo Sandoz (Portugal)
Fentanils (Latvia)
Fentanyl (France, Tunisia)
Injectable; Injection; Fentanyl Citrate 0.05 mg / ml

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