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Fisopred

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Fisopred uses and description

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Fisopred - Fisopred is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Fisopred restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Fisopred contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Fisopred inhibits the activity of fibroblasts and collagen formation.

Fisopred inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.

Fisopred reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.

Fisopred inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.

Fisopred has a vasoconstrictor effect with direct application to the vessels.

Fisopred has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Fisopred enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.

Fisopred inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.

Fisopred also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Fisopred affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.

In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.

When systemic use the therapeutic activity of Fisopred is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local application the therapeutic activity of Fisopred is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

As compared with hydrocortisone the anti-inflammatory activity of Fisopred is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.

Indications: corticosteroid

OralAllergic conditions; collagen diseases (eg, systemic lupus erythematous, acute rheumatic carditis); dermatologic diseases; edematous states; endocrine conditions; GI diseases; hematologic diseases; neoplastic conditions; neoplastic diseases; nervous system conditions (eg, acute exacerbations of multiple sclerosis); ophthalmic conditions; conditions related to organ transplantation; pulmonary disease (eg, asthma); renal condition (eg, nephrotic syndrome); rheumatologic conditions; specific infectious diseases including trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concomitantly with appropriate antituberculous chemotherapy; tuberculosis with pleural or pericardial effusion. Ophthalmic Econopred Plus, Prednisol, Pred ForteTreatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Econopred Plus, PrednisolTreatment of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Pred MildTreatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).

Active ingredients: Prednisolone
Unit description, dosagePrice, USD
Solution; Oral; Prednisolone Sodium Phosphate 5 mg / 5 ml

List of fisopred brand and generic drugs

Fisiopred (Colombia)
Flamasone
Flo-Pred (United States)
Suspension; Oral; Prednisolone Acetate 15 mg / 5 ml
Suspension; Oral; Prednisolone Acetate 5 mg / 5 ml
118 milliliter in 1 bottle, plastic
52 milliliter in 1 bottle, plastic
65 milliliter in 1 bottle, plastic
Fortisone (Thailand)
Fortisone 5 mg x 1,000's
Fortisone 5 mg x 1's
Frisolona
Frisolona Forte (Portugal)
Gatiquin-P
Gatiquin-P Gatifloxacin 0.3 % w/v,Prednisolone acetate 1 % w/v. EYE-DPS / 10ml$ 1.57
Gatiquin-P Gatifloxacin 0.3 % w/v,Prednisolone acetate 1 % w/v. EYE DPS / 10ml$ 1.57
GB Pred AC
GB Pred AC Eye 5 ml Drop$ 0.13
GB-PRED AC (India)
GB-PRED AC 10mg/mL EYE-DPS / 5ml$ 0.67
10 mg x 1 mL x 5ml$ 0.67
Gupisone (Bahrain, Oman)
Hefasolon (Germany)
Hexacorton (Switzerland, Turkey)
Cream; Topical; Prednisolone Acetate
Foam; Topical; Prednisolone Acetate 0.5%
Hexacortone
Cream; Topical; Prednisolone Acetate
Foam; Topical; Prednisolone Acetate 0.5%
HG Cortin
HG Cortin 5 mg Tablet$ 0.01
Histacort Cream (Philippines)
Histacort Cream 5 mg/1 g x 10 g$ 2.90
Hostacortin H
Hostacortin H 5mg TAB / 10$ 0.06
Tablets; Oral; Prednisolone 5 mg
Hostacortin H 5 mg Tablet$ 0.01
HOSTACORTIN-H (India)
5 mg x 10's$ 0.06
Hostacortin-H 5mg TAB / 10$ 0.06
Hostacortina (Portugal)
Hydeltra
Hydeltra-TBA
Injectable; Injection; Prednisolone Tebutate 20 mg / ml
Hydeltrone
Hydeltrone TBA (United States)
Hydrocortancyl (France)
Injectable; Injection; Prednisolone Acetate 25 mg / ml
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
I.P. Predsone (Vietnam)
I.P. Predsone 5 mg x 1 loï 500 Tablet
I.P. Predsone 5 mg x 1 loï 1000 Tablet

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