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Floxal

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Floxal uses and description

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Floxal - Floxal is an antimicrobial agents of broad-spectrum action type from fluoroquinolone group. Bactericidal action of Floxal is due to blockage of the enzyme DNA gyrase in bacterial cells. This medication is highly active against most of gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Mycoplasma spp., Legionella pneumophila, Acinetobacter spp., and Chlamydia spp.

Floxal is active against some gram-positive bacteria (including Staphylococcus spp., Streptococcus spp., especially beta-hemolytic streptococci).

Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp. are moderately susceptible to ofloxacin.

Anaerobic bacteria (except Bacteroides ureolyticus) are insensitive to ofloxacin.

This drug is resistant to beta-lactamases.

Floxal is a quinolone/fluoroquinolone antibiotic. Floxal is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Floxal is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Indication: For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.

Floxal is a fluoroquinolone antibiotic considered to be a second-generation fluoroquinolone. Floxin (branded version) had been discontinued by the manufacturer, in the United States, effective June 18, 2009, though generic equivalents continue to be available.

Floxal is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. When levofloxacin disks were not available in early clinical trials, a 5-pg Floxin (ofloxacin –floxacin) disk was substituted. The U.S. Food and Drug Administration (FDA) medical reviewers considered the two drugs to be one and the same and hence interchangeable.

Like other quinolones, Floxal has been associated with a significant number of serious adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); such reactions may manifest long after therapy had been completed, and, in severe cases, may result in life-long disabilities. Ofloxacin has also been associated with severe psychiatric adverse reactions.

Hepatotoxicity has also been reported with the use of ofloxacin. Case reports of hepatitis have been published for the older fluoroquinolones including ciprofloxacin, ofloxacin, and norfloxacin.

Indications: bacterial eye infections

(ofloxacin ) Tablets are indicated for the treatment of adults with mild to moderate infections (unless otherwise indicated) caused by susceptible strains of the designated microorganisms in the infections listed below. Acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae or Streptococcus pneumoniae. Community-acquired Pneumonia due to Haemophilus influenzae or Streptococcus pneumoniae. Uncomplicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes, or Proteus mirabilis. Acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae. Nongonococcal urethritis and cervicitis due to Chlamydia trachomatis. Mixed Infections of the urethra and cervix due to Chlamydia trachomatis and Neisseria gonorrhoeae. Acute pelvic inflammatory disease (including severe infection) due to Chlamydia trachomatis and/or Neisseria gonorrhoeae. NOTE: If anaerobic microorganisms are suspected of contributing to the infection, appropriate therapy for anaerobic pathogens should be administered. Uncomplicated cystitis due to Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa. Complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter diversus, or Pseudomonas aeruginosa. Prostatitis due to Escherichia coli.

Indications: Genito urinary, respiratory, gastro intestinal.

skin and soft tissue infections.

Peritonitis, Gonorrhoea.

Typhoid fever, Multi drug resistant tuberculosis.

Acute and sub-acute eye and ear infections.

Active ingredients: Ofloxacin
Unit description, dosagePrice, USD
Drops; Ophthalmic; Ofloxacin 0.3%
Ointment; Ophthalmic; Ofloxacin 0.3%
Floxal 200mg TAB / 10$ 1.11
Floxal 200 mg Tablet$ 0.11

List of floxal brand and generic drugs

Floxagen (Philippines)
Floxagen 400 mg x 10 x 10's
Floxal EDO (Germany)
Drops; Ophthalmic; Ofloxacin 0.3%
Floxal Kombi-Packung
Drops; Ophthalmic; Ofloxacin 0.3% / Ointment; Ophthalmic; Ofloxacin 0.3%
Floxal TZ
Floxal TZ 200+600 Tablet$ 0.14
Floxal UD
Drops; Ophthalmic; Ofloxacin 0.3%
Floxal Unidosen
Drops; Ophthalmic; Ofloxacin 0.3%
Floxamed OT
Floxamed OT 200+600 Tablet$ 0.16
Floxaquin
Floxaquin 200mg TAB / 10x10
Floxaquin 200 mg Tablet$ 0.13
Floxaquin O
Floxaquin O 200+500+LB Tablet$ 0.14
FLOXAR (India)
200 mg x 100's$ 9.07
Floxar 200mg TAB / 100$ 9.07
Floxar 200 mg Tablet$ 0.09
Floxavid (Georgia)
Floxavin
Floxavin 200mg TAB / 10x10
Floxaze
Floxaze 200mg TAB / 10$ 0.91
Floxaze 200 mg Tablet$ 0.09
Floxaze OZ
Floxaze OZ 200+500 Tablet$ 0.11
Floxedol (Portugal)
Floxiabh
Floxiabh 100mg TAB / 10$ 0.56
Floxiabh 200mg TAB / 10$ 0.78
Floxicar OZ
Floxicar OZ 200+500 Tablet$ 0.12
Floxicare
Floxicare 200 mg Tablet$ 0.11
Floxicare OZ
Floxicare OZ 30 ml Syrup$ 0.11
FLOXICONTIN (India)
400 mg x 5's$ 2.07
Floxicontin 400mg TAB / 5$ 2.07
Floxicontin O
Floxicontin O 400+500 Tablet$ 0.41
FLOXICONTIN-O (India)
400 mg x 5's$ 2.07
Floxicontin-O 400mg TAB / 5$ 2.07
FLOXICURE (India)
200 mg x 10's$ 1.02
Floxicure 200mg TAB / 10$ 1.02
Floxicure 200 mg Tablet$ 0.10
Floxicure OZ
Floxicure OZ 200+500 Tablet$ 0.14
Floxicure OZ 30 ml Syrup$ 0.11
Floxika (Indonesia)
Floxika 200 mg x 3 x 10's$ 22.44
Floxika 400 mg x 3 x 10's$ 32.64
Floxil (Argentina, Mexico, Peru)
Injectable; Injection; Ofloxacin 4 mg / ml
Tablet; Oral; Ofloxacin 200 mg
Tablet; Oral; Ofloxacin 400 mg
Floxil 2 mg/1 mL x 50 mL x 1's
Floxil 2 mg/1 mL x 100 mL x 1's
Floxil 2 mg/1 mL x 200 mL x 1's

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