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GYNAE - PIL

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GYNAE - PIL uses and description

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GYNAE - PIL - GYNAE - PIL is a man-made form of an amino acid (protein) called lysine. GYNAE - PIL prevents enzymes in the body from breaking down blood clots.

The Cyklokapron and Lysteda brands of GYNAE - PIL are used for different medical conditions.

Cyklokapron is used to prevent bleeding in people with hemophilia who need to have a tooth pulled. This medication is usually given just before the dental procedure, and daily for up to 8 days afterward.

Lysteda is used to treat heavy menstrual bleeding. This medication will not treat premenstrual syndrome (PMS).

GYNAE - PIL may also be used for purposes not listed in this medication guide.

Pharmacology: Inhibits fibrinolysis to stop bleeding.

Indication: For short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction (injection only); treatment of cyclic heavy menstrual bleeding (oral only).

Unlabeled Uses

Treatment of GI hemorrhage, hereditary angioneurotic edema, primary or intrauterine device–induced menorrhagia, or recurrent epistaxis; prevention of perioperative bleeding or rebleeding after subarachnoid hemorrhage.

GYNAE - PIL is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. GYNAE - PIL is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmin, i.e., actions similar to aminocaproic acid. GYNAE - PIL is about 10 times more potent in vitro than aminocaproic acid. GYNAE - PIL binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. GYNAE - PIL in a concentration of 1 mg per mL does not aggregate platelets in vitro. In patients with hereditary angioedema, inhibition of the formation and activity of plasmin by GYNAE - PIL may prevent attacks of angioedema by decreasing plasmin-induced activation of the first complement protein (C1).

Oral Short-term management of haemorrhage

Adult: 1-1.5 g or 15-25 mg/kg 2-4 times daily.

Child: 25 mg/kg bid or tid. Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr. Oral Management of hereditary angioedema

Adult: 1-1.5 g bid or tid.

Child: 25 mg/kg bid or tid. Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr. Intravenous Short-term management of haemorrhage

Adult: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.

Child: 10 mg/kg bid or tid. Renal impairment: Adjust dose based on the serum-creatinine concentration: 120-250 micromol/l: 10 mg/kg bid daily; 250-500 micromoles/l: 10 mg/kg once daily; >500 micromol/l: 5 mg/kg once daily or 10 mg/kg once every 48 hr. Incompatibility: Incompatible with benzylpenicillin.

GYNAE - PIL helps to prevent and reduce bleeding. It is used to control bleeding after certain surgical procedures, especially in people whose blood cannot clot properly or takes a longer time to clot. It may also be used to control bleeding in other situations, as decided by your doctor.

Indications:

Adult: PO Short-term management of haemorrhage 1-1.5 g 2-4 times/day. Long-term management of hereditary angioedema 1-1.5 g 2-3 times/day. IV Short-term management of haemorrhage 0.5-1 g 3 times/day.

Oral Short-term management of haemorrhage

Adult: 1-1.5 g or 15-25 mg/kg 2-4 times daily.

Child: 25 mg/kg bid or tid. Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr. Oral Management of hereditary angioedema

Adult: 1-1.5 g bid or tid.

Child: 25 mg/kg bid or tid. Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr. Intravenous Short-term management of haemorrhage

Adult: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.

Child: 10 mg/kg bid or tid. Renal impairment: Adjust dose based on the serum-creatinine concentration: 120-250 micromol/l: 10 mg/kg bid daily; 250-500 micromoles/l: 10 mg/kg once daily; >500 micromol/l: 5 mg/kg once daily or 10 mg/kg once every 48 hr. Special Populations: Renal impairment: Short-term management of haemorrhage: CrCl: >500 micromol/L: 12.5 mg/kg body wt once daily oral dose or 5 mg/kg IV once daily; 250-500 micromol/L: 25 mg/kg body wt bid oral dose or 10 mg IV once daily; 120-250 micromol/L: 25 mg/kg bid oral dose or 10 mg/kg body wt IV bid. Incompatibility: Incompatible with benzylpenicillin.

General and local bleeding or bleeding diseases.

Active ingredients: Tranexamic Acid
Unit description, dosagePrice, USD
GYNAE - PIL Capsule/ Tablet / 502mg (10 units)$ 2.31
GYNAE - PIL Capsule/ Tablet / 500mg (10 units)$ 2.31

List of gynae - pil brand and generic drugs

Gynae-PIL Forte (India)
10's$ 2.69
Hanexic (Vietnam)
Hanexic 250 mg/5 mL x 10 oáng
He Mo Sai (China)
Hemlon (Japan)
Hemlon S (Japan)
Hemostan (Philippines)
Hemostan 250 mg x 100's$ 45.38
Hemostan 500 mg x 100's$ 61.56
Hemostan 250 mg/2.5 mL x 5's$ 19.14
Hemostan 500 mg/5 mL x 5's$ 22.87
Hemostop (Philippines)
Hemostop 50 mg/1 mL x 10's
Hemostop 500 mg Tablet$ 0.17
Hemostop 250 mg Tablet$ 0.09
Hemotran (Vietnam)
Hemotran 500 mg x 100's
Hemotran 500 mg/5 mL x 10 oáng
Hemotrex (Philippines)
Hemotrex 500 mg x 10's
Hemotrex 500 mg x 100's
Hemoxane (Philippines)
Hemoxane 500 mg x 50's
Hemsamic (Myanmar)
Hemstate TX
Hemstate TX 500 mg Injection$ 0.19
Hemstate TX 250+250 Tablet$ 0.14
Hexakapron (Israel)
Injectable; Injection; Tranexamic Acid 10%
Tablet; Oral; Tranexamic Acid 500 mg
Hexamic (Vietnam)
Hexamic/Medsamic (Vietnam)
Hexamic/Medsamic 250 mg x 10 Blister x 10 Tablet
Hexamic/Medsamic 250 mg x 2 Blister x 10 Tablet
Hexamic/Medsamic 500 mg x 20 Tablet
Hexamic/Medsamic 500 mg x 100 Tablet
Hexamic/Medsamic 250 mg/5 mL x 10 oáng
Hexamic/Medsamic 500 mg/5 mL x 10 oáng
Hexapromin
Hexatron (Japan)
Intermic (Indonesia)
Intermic 250 mg/5 mL x 5's$ 2.96
Intrax (Bangladesh)
JieNing (China)
Jiening-Bei Te Pharm (China)
Ka Wei An (China)
Kalnex (Indonesia)
Kalnex 250 mg x 10 x 10's$ 13.92
Kalnex 500 mg x 10 x 10's$ 23.87
Kalnex 50 mg/1 mL x 5 mL x 10's$ 7.65
Kalnex 100 mg/1 mL x 5 mL x 10's$ 10.28
Kansamin (Taiwan)
Kansamin 250 mg
Kansamin 100 mg/1 mL x 5 mL x 10's

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