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Gabapentin ABC

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Gabapentin ABC uses and description

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Gabapentin ABC - Used for: Treating nerve pain caused by shingles. It may also be used for other conditions as determined by your doctor.

Gabapentin ABC is an analgesic for neuropathic (nerve) pain. Exactly how it works to treat nerve pain is not known.

Pharmacology: Mechanism unknown; Gabapentin ABC enacarbil is a prodrug of gabapentin.

Indication: Adjunctive therapy in treatment of partial seizures with or without secondary generalization in patients older than 12 y with epilepsy (immediate release); adjunctive therapy for partial seizures in children 3 to 12 y of age; management of postherpetic neuralgia in adults (immediate release); treatment of moderate to severe primary restless legs syndrome in adults (ER).

Unlabeled Uses

Agitation in dementia; alcohol withdrawal; bipolar disorder; cocaine withdrawal; diabetic neuropathy; fibromyalgia; headaches; hiccups (singultus); hot flashes (cancer- and/or postmenopausal-related); hyperhidrosis; nausea (cancer-related); neuralgia/neuropathy/chronic pain; prevention of migraine; pruritus (brachioradial/cholestatic/uremic); rectal administration; restless legs syndrome (immediate release); tremors in multiple sclerosis.

Gabapentin ABC is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Gabapentin ABC is different from other anticonvulsants acting through GABA synapses (including valproate, barbiturates, benzodiazepines, inhibitors of GABA-transaminase, inhibitors of GABA capture, GABA agonists and prodrugs of GABA). In in vitro studies showed that Gabapentin ABC is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Gabapentin ABC and its derivatives. Gabapentin ABC in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.

The final mechanism of action of Gabapentin ABC is not defined.

Gabapentin ABC, an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Gabapentin ABC has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn\'t possess the usual drug interactions.

Gabapentin ABC is used to treat epilepsy (also known as seizures or fits). It is also used to relieve nerve pain in people with diabetes or shingles. Gabapentin ABC may also be used to relieve hot flushes in women with breast cancer and in women who have passed menopause.

Oral Epilepsy (partial seizures with or without secondary generalisation)

Adult: Initially, 300 mg on the 1st day, 300 mg bid on the 2nd day and 300 mg tid on the 3rd day. Thereafter, may increase dose until effective antiepileptic control is achieved. Usual maintenance range: 0.9-3.6 g daily; daily dose to be taken in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g daily.

Child: 6-12 yr: Initially, 10 mg/kg on the 1 st day, 20 mg/kg on the 2 nd day and 25-35 mg/kg on the 3 rd day.

Maintenance: 1200 mg daily (37-50 kg); 900 mg daily (26-36 kg). Total daily dose to be taken in 3 equally divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Oral Neuropathic pain

Adult: Titrate to a max of 1.8 g daily in 3 divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days.

Indications:

Adult: PO Epilepsy Initial: 300 mg on the 1st day, 300 mg twice daily on the 2nd day and 300 mg 3 times/day on the 3rd day. Thereafter, may increase dose based on response.

Maintenance: 0.9-3.6 g/day in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g/day. Neuropathic pain Up to a max of 1.8 g/day in 3 divided doses.

Oral Epilepsy

Adult: Initially, 300 mg on the 1st day, 300 mg bid on the 2nd day and 300 mg tid on the 3rd day. Thereafter, may increase dose until effective antiepileptic control is achieved. Usual maintenance range: 0.9-3.6 g daily; daily dose to be taken in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g daily.

Child: 6-12 yr: Initially, 10 mg/kg on the 1 st day, 20 mg/kg on the 2 nd day and 25-35 mg/kg on the 3 rd day.

Maintenance: 1200 mg daily (37-50 kg); 900 mg daily (26-36 kg). Total daily dose to be taken in 3 equally divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Oral Neuropathic pain

Adult: Titrate to a max of 1.8 g daily in 3 divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Special Populations: Renal impairment: CrCl: 50-79 mL/min: 600-1200 mg daily; 30-49 mL/min: 300-600 mg daily; 15-29 mL/min: 150 mg daily (or 300 mg every other day) to 300 mg daily; <15 mL/min: 150 mg daily (or 300 mg every other day). To be given in 3 divided doses. Recommended loading dose for patients undergoing haemodialysis who have never received gabapentin: 300-400 mg, followed by 200-300 mg after each 4 hr of haemodialysis.

Active ingredients: Gabapentin
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List of gabapentin abc brand and generic drugs

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Gabapentina Ratiopharm (Portugal, Spain)
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