Heparine Natrium - Used for: Preventing harmful blood clots.
Heparine Natrium is an anticoagulant. It works by blocking reactions in the body that lead to blood clots.
Pharmacology: Inhibits reactions that lead to clotting of blood and formation of fibrin clots. Heparine Natrium acts at multiple sites in the normal coagulation system.
Indication: Prophylaxis and treatment of venous thrombosis and its extensions, pulmonary embolism (PE), peripheral arterial embolism, and atrial fibrillation with embolization; diagnosis and treatment of acute and chronic consumption coagulopathies (disseminated intravascular coagulation [DIC]); prevention of postoperative deep venous thrombosis (DVT) and PE. Also used to maintain catheter patency and as an anticoagulant in blood transfusions, extracorporeal circulation, dialysis, and laboratory samples.
Unfractionated Heparine Natrium is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from 3000 to 30,000 daltons. Heparine Natrium is obtained from liver, lung, mast cells, and other cells of vertebrates. Heparine Natrium is a well-known and commonly used anticoagulant which has antithrombotic properties. Heparine Natrium inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Small amounts of Heparine Natrium in combination with antithrombin III, a Heparine Natrium cofactor,) can inhibit thrombosis by inactivating Factor Xa and thrombin. Once active thrombosis has developed, larger amounts of Heparine Natrium can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparine Natrium also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Heparine Natrium prolongs several coagulation tests. Of all the coagulation tests, activated partial prothrombin time (aPTT) is the most clinically important value.
Heparine Natrium is an anticoagulant (blood thinner) that prevents the formation of blood clots.
Heparine Natrium is used to treat and prevent blood clots in the veins, arteries, or lung. Heparine Natrium is also used before surgery to reduce the risk of blood clots.
Heparine Natrium may also be used for other purposes other than those listed in this medication guide.
Intravenous unstable angina
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous Venous thromboembolism
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous acute peripheral arterial embolism
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous Prevention of re-occlusion of the coronary arteries following thrombolytic therapy in myocardial infarction
Adult: 5000 u IV followed by 1000 u/hr IV with alteplase. Subcutaneous Venous thromboembolism
Adult: 15,000 u injected every 12 hr.
Child: 250 u/kg every 12 hr. Subcutaneous Prophylaxis of postoperative venous thromboembolism including during pregnancy with a history of deep-vein thrombosis or pulmonary embolism
Adult: 5000 u given 2 hr before surgery then every 8-12 hr for 7 days or until the patient is ambulant, may increase to 10,000 u every 12 hr during the 3 rd trimester of pregnancy. Subcutaneous Prevention of mural thrombosis
Adult: 12,500 u every 12 hr for at least 10 days. Incompatibility: Heparine Natrium calcium or sodium is reported to be incompatible with alteplase, reteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cefalotin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, meticillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride and vinblastine sulfate. Heparine Natrium sodium has also been reported to be incompatible with cisatracurium besilate, labetalol hydrochloride, levofloxacin, nicardipine hydrochloride and vinorelbine tartrate.
Indications:
Adult: IV Unstable angina ; Venous thromboembolism ; Peripheral arterial embolism Loading dose: 5,000 u, then 1,000-2,000 u/hr. Prevention of re-occlusion of the coronary arteries following thrombolytic therapy in MI 5,000 u, then 1,000 u/hr w/ alteplase. SC Venous thromboembolism 15,000 u 12 hrly. Prevention of post-op venous thromboembolism 5,000 u 2 hr before surgery, then 8-12 hrly for 7 days or until patient is ambulant. Prevention of mural thrombosis 12,500 u 12 hrly for at least 10 days.
Subcutaneous Venous thromboembolism
Adult: 15,000 u injected every 12 hr.
Child: 250 u/kg every 12 hr. Subcutaneous Prophylaxis of postoperative venous thromboembolism
Adult: 5000 u given 2 hr before surgery then every 8-12 hr for 7 days or until the patient is ambulant, may increase to 10,000 u every 12 hr during the 3 rd trimester of pregnancy. Subcutaneous Prophylaxis of mural thrombosis
Adult: 12,500 u every 12 hr for at least 10 days. Intravenous Unstable angina
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous Venous thromboembolism
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous Peripheral arterial embolism
Adult: 5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr.
Child: Administer a lower loading dose.
Maintenance: 15-25 u/kg/hr continuous infusion. Intravenous Prophylaxis of re-occlusion of the coronary arteries following thrombolytic therapy in myocardial infarction
Adult: 5000 u IV followed by 1000 u/hr IV with alteplase. Incompatibility: Heparine Natrium calcium or sodium is reported to be incompatible with alteplase, reteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cefalotin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, meticillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride and vinblastine sulfate. Heparine Natrium sodium has also been reported to be incompatible with cisatracurium besilate, labetalol hydrochloride, levofloxacin, nicardipine hydrochloride and vinorelbine tartrate.
Unstable angina, Venous thromboembolism, Peripheral arterial embolism, Prophylaxis of re-occlusion of the coronary arteries following thrombolytic therapy in myocardial infarction, Venous thromboembolism, Prophylaxis of postoperative venous thromboembolism, Prophylaxis of mural thrombosis, |
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