Hyzone - Hyzone is a first-generation antihistamine of the piperazine class that is an H1 receptor antagonist. It was synthesized in the early 1950s. It is used primarily as an antihistamine for the treatment of itches and irritations, an antiemetic for the reduction of nausea, as a weak analgesic by itself and as an opioid potentiator, and as an anxiolytic for the treatment of anxiety.
Hyzone preparations usually require a doctor's prescription, as do other potent antihistamines in many countries; whereas some countries allow Hyzone and all or most other antihistamines to be sold over the counter.
Even though it is an effective sedative, hypnotic, and tranquilizer, it shares almost none of the abuse, dependence, addiction, and toxicity potential of other drugs used for the same range of therapeutic reasons. Drugs related to Hyzone are cyclizine, buclizine, and meclizine and they share all or most of the benefits, indications, contraindications, cautions, and side effects of hydroxyzine. The second-generation antihistamine cetirizine is one of the metabolites of hydroxyzine.
Indications: Pruritus due to acute and chronic urticaria, dermatosis.
Short term management of anxiety (rarely used).
Adjunct to pre or postoperative sedation.