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Isradipine

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Isradipine uses and description

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Isradipine - Used for: Treating high blood pressure. Isradipine may be used alone on in combination with other high blood pressure medications. It may also be used for other conditions as determined by your doctor.

Isradipine is a calcium channel blocker. It works by dilating (widening) the arteries.

Isradipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.

Isradipine is used to treat high blood pressure (hypertension). It is sometimes given with other blood pressure medications.

Isradipine may also be used for purposes other than those listed in this medication guide.

Pharmacology: Reduces systemic vascular resistance and BP by inhibiting movement of calcium ions across cell membrane in systemic and coronary vascular smooth muscle and myocardium.

Indication: Treatment of hypertension.

Isradipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of Isradipine result in an overall decrease in blood pressure.

Isradipine helps to keep your blood pressure under control. Isradipine relaxes your blood vessels and this helps to lower your blood pressure.

Oral Hypertension

Adult: Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required.

Elderly: Initially, 1.25 mg bid.

Maintenance: 2.5 or 5 mg once or twice daily. Hepatic impairment: Initially 1.25 mg bid titrated slowly to

Maintenance: 2.5 or 5 mg once or twice daily.

Oral Hypertension

Adult: Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required.

Elderly: Initially, 1.25 mg bid.

Maintenance: 2.5 or 5 mg once or twice daily. Hepatic impairment: Initially 1.25 mg bid titrated slowly to

Maintenance: 2.5 or 5 mg once or twice daily. Special Populations: Renal or hepatic impairment: 1.25 mg bid.

Maintenance: 2.5 or 5 mg once daily.

Indications: HTN.

Active ingredients: Isradipine
Unit description, dosagePrice, USD
Capsule; Oral; Isradipine 2.5 mg
Capsule; Oral; Isradipine 5 mg
DynaCirc CR 10 mg 24 Hour tablet$ 5.59
Dynacirc cr 10 mg tablet$ 4.41
DynaCirc CR 5 mg 24 Hour tablet$ 3.00
Dynacirc cr 5 mg tablet$ 2.88
DynaCirc 5 mg capsule$ 2.31
Isradipine 5 mg capsule$ 2.00
DynaCirc 2.5 mg capsule$ 1.59
Isradipine 2.5 mg capsule$ 1.39

List of isradipine brand and generic drugs

Clivoten (Italy)
Dilatol (Portugal)
DynaCirc (Colombia, Guyana, Hong Kong, Malaysia, New Zealand, Singapore, South Africa, Taiwan, Thailand, United States)
Capsule; Oral; Isradipine 2.5 mg
Capsule; Oral; Isradipine 5 mg
Dynacirc 2.5 mg x 56's
Dynacirc 2.5 mg x 6 x 56's
Dynacirc SRO 5 mg x 30's
DynaCirc SRO (Singapore)
Capsule, Sustained Release; Oral; Isradipine 2.5 mg
Capsule, Sustained Release; Oral; Isradipine 5 mg
Dynacirc SRO 5 mg x 30's$ 42.40
Dynacirc-Sro (Turkey)
Dynacire
Dynacire CR
Dynacrine
Esradin (Italy)
Icaz (France, Tunisia)
Capsule, Prolonged Release; Oral; Isradipine 2.5 mg
Capsule, Prolonged Release; Oral; Isradipine 5 mg
Icaz SRO (Philippines)
Icaz SRO 2.5 mg x 50's$ 42.50
Isradipine Mikah (United States)
Lomir (Austria, Bangladesh, Belgium, Brazil, Czech Republic, Ethiopia, Finland, Ghana, Greece, Hungary, Iceland, Kenya, Libya, Luxembourg, Netherlands, Nigeria, Norway, Oman, Portugal, Russian Federation, Slovakia, Spain, Sudan, Sweden, Zambia, Zimbabwe)
Capsule; Oral; Isradipine 2.5 mg
Capsule; Oral; Isradipine 5 mg
Tablet; Oral; Isradipine 2.5 mg
Lomir Retard (Denmark)
Lomir SRO (Austria, Czech Republic, Italy, Norway, Poland, Sweden, Switzerland)
Tablet; Oral; Isradipine 2.5 mg
Tablet; Oral; Isradipine 5 mg
Lomir SRO Mite
Tablet; Oral; Isradipine 2.5 mg
Prescal (Ireland, United Kingdom)
Tablet; Oral; Isradipine 2.5 mg
Rebriden
Vascal (Germany)
Tablet; Oral; Isradipine
Vascal Uno
Capsule, Retard; Oral; Isradipine
Vascal Uno Mite
Capsule, Retard; Oral; Isradipine
Vaslan
 
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