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Itrol

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Itrol uses and description

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Itrol - Itrol is an antifungal medication.

Itrol is used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.

Itrol may also be used for purposes not listed in this medication guide.

Pharmacology: Inhibits the CYP-450–dependent synthesis of ergosterol, which is a vital component of fungal cell membranes.

Indication: Capsules

Treatment of aspergillosis, blastomycosis, and histoplasmosis in immunocompromised and nonimmunocompromised patients; treatment of onychomycosis of fingernail or toenail with or without fingernail involvement in nonimmunocompromised patients.

Solution

Treatment of oropharyngeal or esophageal candidiasis.

Unlabeled UsesSolution

Recommended as an alternative to fluconazole as secondary prevention of oropharyngeal, vaginal, or esophageal candidiasis in HIV-infected patients who have severe or frequent recurrences.

Capsules

Alternative to fluconazole for prevention of Cryptococcus in adults with advanced HIV disease (CD4 counts less than 50 cell/mcL) and recommended as an alternative to fluconazole for lifelong secondary prevention of cryptococcal disease in HIV-infected adults; first-line agent in the primary prevention of histoplasmosis in adults with advanced HIV disease (CD4 counts less than 100 cells/mcL) and who live in endemic areas (rate of at least 10 cases per 100 patient-years), and also as first-line agent for lifelong secondary prophylaxis; recommended as an alternate agent to fluconazole for lifelong secondary prevention of coccidioidomycosis in HIV-infected adults. Oral Itrol is recommended also for secondary prevention of histoplasmosis, cryptococcal disease, and coccidioidomycosis in children with HIV; and primary prevention of histoplasmosis (first-line agent) and cryptococcal disease (alternate therapy) in children with HIV and severe immunosuppression who live in endemic areas (histoplasmosis).

Itrol is an imidazole/triazole type antifungal agent. Itrol is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itrol exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

Itrol is an antifungal medicine. It is used to prevent or treat fungal infections of the lung, mouth, throat, nails or other organs.

Oral Oesophageal candidiasis

Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for 20 sec before swallowing. Double the dose in resistant infections. Oral Oral candidiasis

Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for 20 sec before swallowing. Double the dose in resistant infections. Oral Prophylaxis of fungal infections in immunocompromised patients

Adult: As oral liquid: 5 mg/kg daily in 2 divided doses. Oral Oropharyngeal candidiasis

Adult: As capsule: 100 mg daily for 15 days. Oral Vulvovaginal candidiasis

Adult: As capsule: 200 mg bid for 1 day. Oral Pityriasis versicolor

Adult: As capsule: 200 mg daily for 7 days. Oral Tinea cruris

Adult: As capsule: 100 mg daily for 15 days or 200 mg daily for 7 days. Oral Tinea corporis

Adult: As capsule: 100 mg daily for 15 days or 200 mg daily for 7 days. Oral Nail fungal infections

Adult: As capsule: 200 mg daily for 3 mth. Alternatively, pulse therapy with 200 mg bid for 7 days, repeated once for fingernail infections and twice for toenail infections after drug-free intervals of 21-days. Oral Systemic fungal infections

Adult: As capsule: 100-200 mg once daily, increased to 200 mg bid for invasive or disseminated infections. For life-threatening infections: Loading dose of 200 mg tid for 3 days has been given. Oral Primary or secondary prophylaxis of infections in neutropenic or AIDS patients

Adult: As capsule: 200 mg daily increased to 200 mg bid if necessary. Oral Tinea pedis

Adult: As capsule: 100 mg daily for 30 days or 200 mg bid for 7 days Oral Tinea manuum

Adult: As capsule: 100 mg daily for 30 days or 200 mg bid for 7 days Intravenous Systemic fungal infections

Adult: 200 mg infused bid over 1 hr for 2 days.

Maintenance: 200 mg daily. Special Populations: Treatment of oropharyngeal candidiasis in patients with AIDS or neutropenia: Increase dose to 200 mg as capsules daily for 15 days.

Indications:

Adult: PO Oesophageal candidiasis ; Oral candidiasis As oral liq: 200 mg/day in 1-2 divided doses. Double the dose in resistant infections. Prophylaxis of fungal infections in immunocompromised patients As oral liq: 5 mg/kg/day in 2 divided doses. Oropharyngeal candidiasis As cap: 100 mg/day for 15 days. Vulvovaginal candidiasis As cap: 200 mg twice daily for 1 day. Pityriasis versicolor As cap: 200 mg/day for 7 days. Tinea corporis ; Tinea cruris As cap: 100 mg/day for 15 days. Fungal nail infections As cap: 200 mg/day for 3 mth. Systemic fungal infections As cap: 100-200 mg once daily, up to 200 mg twice daily for invasive or disseminated infections. Prophylaxis of infections in neutropenic or AIDS patients As cap: 200 mg/day, up to 200 mg twice daily if needed. Tinea pedis ; Tinea manuum As cap: 100 mg/day for 30 days. IV Systemic fungal infections 200 mg twice daily for 2 days.

Maintenance: 200 mg/day.

Oral Oesophageal candidiasis

Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for 20 sec before swallowing. Double the dose in resistant infections. Oral Oral candidiasis

Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for 20 sec before swallowing. Double the dose in resistant infections. Oral Prophylaxis of systemic fungal infections in immunocompromised patients

Adult: As oral liquid: 5 mg/kg daily in 2 divided doses. Oral Oropharyngeal candidiasis

Adult: As capsule: 100 mg daily for 15 days. Oral Vulvovaginal candidiasis

Adult: As capsule: 200 mg bid for 1 day. Oral Pityriasis versicolor

Adult: As capsule: 200 mg daily for 7 days. Oral Tinea corporis and tinea cruris

Adult: As capsule: 100 mg daily for 15 days or 200 mg daily for 7 days. Oral Fungal nail infections

Adult: As capsule: 200 mg daily for 3 mth. Alternatively, pulse therapy with 200 mg bid for 7 days, repeated once for fingernail infections and twice for toenail infections after drug-free intervals of 21-days. Oral Systemic fungal infections

Adult: As capsule: 100-200 mg once daily, increased to 200 mg bid for invasive or disseminated infections. For life-threatening infections: Loading dose of 200 mg tid for 3 days has been given. Oral Primary or secondary prophylaxis of infections in neutropenic or AIDS patients

Adult: As capsule: 200 mg daily increased to 200 mg bid if necessary. Oral Tinea pedis or tinea manuum

Adult: As capsule: 100 mg daily for 30 days or 200 mg bid for 7 days Intravenous Systemic fungal infections

Adult: 200 mg infused bid over 1 hr for 2 days.

Maintenance: 200 mg daily. Special Populations: Treatment of oropharyngeal candidiasis in patients with AIDS or neutropenia: Increase dose to 200 mg as capsules daily for 15 days.

Active ingredients: Itraconazole
Unit description, dosagePrice, USD

List of itrol brand and generic drugs

Itrocol
Itrocol 100mg CAP / 4$ 2.59
ITROLE (India)
100 mg x 4's$ 2.52
Itrole 100 mg Capsule$ 0.63
Itrole 10mg CAP / 4$ 2.52
Itrosac
Itrosac 100mg CAP / 10$ 2.96
Itzol (Indonesia)
Itzol 100 mg x 12's$ 13.46
ITZUCIA (India)
100 mg x 8's
Itzucia 100mg CAP / 8
Kanazol (Serbia)
Konitra (South Korea)
Laverio (Greece)
Lorenzol (Greece)
Lozartil (Mexico)
Capsule; Oral; Itraconazole 100 mg
Lyposil (South Korea)
Mei Fu (China)
Merck-Itraconazole (South Africa)
Mesmor (Greece)
Miconihol
Capsule; Oral; Itraconazole 100 mg
Micotenk (Argentina)
Micronazol (Greece)
Mycodrox (Greece)
Mycotrazol (Indonesia)
Mycotrazol 100 mg x 3 x 4's$ 23.06
Mylan Itraconazole (South Africa)
Neo Itrax
Neo-Candimyk (Greece)
Newtrazole (South Korea)
Niddazol (Denmark)
Nitridazol (Argentina)
Norspor (Thailand)
Norspor 100 mg x 25 x 4's
Nufatrac (Indonesia)
Nufatrac 100 mg x 5 x 10's$ 76.24
Omicral (Hungary)
Oriconazole
Oromic (Spain)
Orungal (Estonia, Georgia, Hungary, Latvia, Lithuania, Poland, Romania, Russian Federation)
Capsule; Oral; Itraconazole 100 mg
Solution; Oral; Itraconazole 100 mg / 10 ml
Orungamin
Capsule; Oral; Itraconazole 100 mg
Orunit (Russian Federation)
Capsule; Oral; Itraconazole 100 mg
Panastat (Argentina)
Petrazole (Indonesia)
Petrazole 100 mg x 12's$ 20.87
Pharmaniaga Itraconazole (Hongkong)
Pharmaniaga Itraconazole 100 mg x 3 x 10's
Pharmitrole (Vietnam)
Pharmitrole 100 mg x 3 Blister x 10 Tablet
Prokanazol (Czech Republic, Estonia, Serbia)

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