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Lafigin DT

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Lafigin DT uses and description

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Lafigin DT - Pharmacology: Chemically unrelated to existing antiepileptic drugs (AEDs); precise mechanism(s) unknown. One proposed mechanism suggests inhibition of voltage-sensitive sodium channels, thereby stabilizing neuronal membranes that modulate presynaptic transmitter release of excitatory amino acids (eg, aspartate, glutamate).

Indication: Bipolar disorder (immediate release only)

Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes in adults treated for acute mood episodes with standard therapy.

Epilepsy

Adjunctive therapy for partial seizures, the generalized seizures of Lennox-Gastaut syndrome, and primary generalized tonic-clonic seizures in adults and children 2 yr of age and older (immediate release); for partial-onset seizures with or without secondary generalization and primary generalized tonic-clonic seizures in patients at least 13 yr of age (ER); conversion to monotherapy in adults with partial seizures who are receiving treatment with carbamazepine, phenobarbital, phenytoin, primidone, or valproate as a single AED (immediate release).

Unlabeled Uses

Management of children with absence seizures, juvenile myoclonic epilepsy, and temporal lobe seizures; postpoliomyelitis syndrome; prevention of migraines in adults; rectal administration.

Lafigin DT, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lafigin DT is also used in the treatment of depression and bipolar disorder. Lafigin DT is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lafigin DT inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.

Lafigin DT is used to treat epilepsy (also known as fits or seizures). It may be used on its own or together with other epilepsy medicines. It is also used to treat a mood disturbance called bipolar disorder.

Oral Epilepsy

Adult: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100-200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily.

Child: >12 yr: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100 -200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. <12 yr: Not recommended. Max

Dosage:

Adult: 500 mg daily. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Adjunct in epilepsy

Adult: With valproate: Initially, 25 mg on alternate days for 2 wk followed by 25 mg once daily for 2 wk; thereafter, increase by a max of 25-50 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses. With enzyme-inducing antiepileptics but not with valproate: 50 mg once daily for 2 wk followed by 50 mg bid for 2 wk; thereafter, increase by a max of 100 mg every 1-2 wk; usual maintenance doses: 200-400 mg/day in 2 divided doses; up to 700 mg/day in some patients. With oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter increase dose by a max of 50-100 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses; up to 500 mg daily in some patients.

Child: With valproate: Initially, 0.15 mg/kg once daily for 2 wk followed by 0.3 mg/kg once daily for 2 wk; thereafter, increase by a max of 0.3 mg/kg every 1-2 wk to usual maintenance doses of 1-5 mg/kg once daily or in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Bipolar disorder

Adult: Monotherapy: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 200 mg daily. Max dose: 200 mg/day. With valproate: Initially, 25 mg every other day for 2 wk followed by 25 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 100 mg daily. With enzyme-inducing antiepileptics but not with valproate: Initially, 50 mg once daily for 2 wk followed by 100 mg daily in 2 divided doses for 2 wk; thereafter, increase in 100-mg increments wkly to usual maintenance dose of 400 mg daily in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%.

Indications:

Adult: PO Epilepsy Initial: 25 mg once daily for 2 wk, then 50 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. Up to 500 mg/day in some patients. Adjunct in epilepsy W/ valproate: Initial: 25 mg on alternate days for 2 wk, followed by 25 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. W/ enzyme-inducing antiepileptics (except valproate): 50 mg once daily for 2 wk, followed by 50 mg twice daily for 2 wk.

Maintenance: 200-400 mg/day. Up to 700 mg/day in some patients. W/ oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk.

Maintenance: 100-200 mg/day. Up to 500 mg/day in some patients. Bipolar disorder Monotherapy: Initial : 25 mg once daily for 2 wk, increase gradually to maintenance dose: 200 mg/day. W/ valproate: Initial: 25 mg every other day for 2 wk, increase gradually to

Maintenance: 100 mg/day. W/ enzyme-inducing drugs (except valproate): Initial: 50 mg once daily for 2 wk, then increase gradually to

Maintenance: 400 mg/day in 2 divided doses.

Oral Epilepsy

Adult: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100-200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily.

Child: >12 yr: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100 -200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. <12 yr: Not recommended. Max

Dosage:

Adult: 500 mg daily. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Adjunct in epilepsy

Adult: With valproate: Initially, 25 mg on alternate days for 2 wk followed by 25 mg once daily for 2 wk; thereafter, increase by a max of 25-50 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses. With enzyme-inducing antiepileptics but not with valproate: 50 mg once daily for 2 wk followed by 50 mg bid for 2 wk; thereafter, increase by a max of 100 mg every 1-2 wk; usual maintenance doses: 200-400 mg/day in 2 divided doses; up to 700 mg/day in some patients. With oxcarbazepine but no enzyme-inducing or -inhibiting antiepileptics: 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter increase dose by a max of 50-100 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily in 1-2 divided doses; up to 500 mg daily in some patients.

Child: With valproate: Initially, 0.15 mg/kg once daily for 2 wk followed by 0.3 mg/kg once daily for 2 wk; thereafter, increase by a max of 0.3 mg/kg every 1-2 wk to usual maintenance doses of 1-5 mg/kg once daily or in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Oral Bipolar disorder

Adult: Monotherapy: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 200 mg daily. Max dose: 200 mg/day. With valproate: Initially, 25 mg every other day for 2 wk followed by 25 mg once daily for 2 wk; thereafter, double the daily dose at wkly intervals to usual maintenance dose of 100 mg daily. With enzyme-inducing antiepileptics but not with valproate: Initially, 50 mg once daily for 2 wk followed by 100 mg daily in 2 divided doses for 2 wk; thereafter, increase in 100-mg increments wkly to usual maintenance dose of 400 mg daily in 2 divided doses. Hepatic impairment: Moderate impairment (Child-Pugh category B): Reduce dose by about 50%. Severe impairment (Child-Pugh category C): Reduce dose by about 75%. Special Populations: Reduce dose by 50% in patients with moderate hepatic impairment and 75% in severe hepatic impairment.

Epilepsy:Adjunctive Use: Lafigin DT is indicated as adjunctive therapy for partial seizures and also the generalized seizures of Lennox-Gastaut syndrome in adults and pediatric patients (>/=2 years of age).Monotherapy Use: Lafigin DT is indicated for conversion to monotherapy in adults with partial seizures. Bipolar Disorder: Lafigin DT is indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes).

Used for: Your medicine is called Lafigin DT Dispersible Tablets.

The active ingredient is Lamotrigine. Lafigin DT belong to a group of medicines called anticonvulsants (antiepileptics). Lafigin DT is used to treat the following types of seizures (fits or convulsions) due to bursts of abnormal electrical activity in the brain:

  • Simple partial seizures (in which consciousness is retained) that affect one side of the brain
  • Complex partial seizures (in which consciousness is impaired or lost) that affect one side of the brain
  • Generalised tonic-clonic seizures (loss of consciousness, generalised muscle contraction [tonic] followed by shaking or convulsions [clonic]) that affect both sides of the brain
  • Seizures associated with Lennox-Gastaut Syndrome an uncommon form of epilepsy with variable symptoms affecting a small proportion of children with epilepsy.

Your medicine may be used on its own to treat adults and children over 12 years.

Your medicine can also be used in combination with other anti-epileptic medicines in both adults and children age 2 years and over.

Active ingredients: Lamotrigine
Unit description, dosagePrice, USD
Tablet; Oral; Lamotrigine 100 mg
Tablet; Oral; Lamotrigine 200 mg
Tablet; Oral; Lamotrigine 25 mg
Tablet; Oral; Lamotrigine 50 mg

List of lafigin dt brand and generic drugs

Lagotran (Argentina)
Lamal (Bulgaria, Croatia (Hrvatska), Serbia)
Lambipol (Belgium, Luxembourg)
Lamdra DM
Tablet; Oral; Lamotrigine 100 mg
Tablet; Oral; Lamotrigine 25 mg
Tablet; Oral; Lamotrigine 5 mg
Lamdra SBK 12
Tablet, Extended Release; Oral; Lamotrigine 10 mg
Tablet, Extended Release; Oral; Lamotrigine 100 mg
Tablet, Extended Release; Oral; Lamotrigine 25 mg
Tablet, Extended Release; Oral; Lamotrigine 50 mg
Lamdra SBK 24
Tablet, Extended Release; Oral; Lamotrigine 10 mg
Tablet, Extended Release; Oral; Lamotrigine 100 mg
Tablet, Extended Release; Oral; Lamotrigine 25 mg
Tablet, Extended Release; Oral; Lamotrigine 50 mg
Lamect (Serbia)
Lamep (Colombia)
Lamepil (Estonia, Latvia, Lithuania)
Lamepil 25mg TAB / 10$ 0.61
Lamepil 50mg TAB / 10$ 1.09
Lamepil 100mg TAB / 10$ 1.94
25 mg x 10's$ 0.61
50 mg x 10's$ 1.09
100 mg x 10's$ 1.94
LAMEPRIL-MR (India)
50 mg x 10's$ 1.20
100 mg x 10's$ 2.22
Lamepril-MR 50mg TAB / 10$ 1.20
Lamepril-MR 100mg TAB / 10$ 2.22
Lameptil (Croatia (Hrvatska), Romania, Slovenia)
Lameptil S (Poland)
Lametec (India)
25 mg x 10's$ 0.67
50 mg x 10's$ 1.21
100 mg x 10's$ 2.13
Lametec 25mg TAB / 10$ 0.67
Lametec 50mg TAB / 10$ 1.21
Lametec 100mg TAB / 10$ 2.13
LAMETEC-DT (India)
5 mg x 10's$ 0.23
25 mg x 10's$ 0.88
50 mg x 10's$ 1.57
100 mg x 10's$ 2.77
Lametec-DT 5mg DT-TAB / 10$ 0.23
Lametec-DT 25mg DT-TAB / 10$ 0.88
Lametec-DT 50mg DT-TAB / 10$ 1.57

Show all Lafigin DT generic names
 
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