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Lenalidomide

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Lenalidomide uses and description

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Lenalidomide - Pharmacology: Possesses antineoplastic, immunomodulatory, and antiangiogenic properties. Inhibits the secretion of proinflammatory cytokines and increases the secretion of anti-inflammatory cytokines.

Indication: Treatment of patients with transfusion-dependent anemia due to low or intermediate-1 risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality, with or without additional cytogenetic abnormalities; treatment of multiple myeloma in combination with dexamethasone in patients who have received at least 1 prior therapy.

Unlabeled Uses

Behçet syndrome.

Lenalidomide affects the immune system. It helps promote immune responses to prevent inflammation in the body.

Lenalidomide treats anemia (a lack of red blood cells in the body) and multiple myeloma (cancer resulting from a progressive blood disease). It is used in patients with myelodysplastic syndrome caused by an abnormal chromosome. This disorder is also called deletion 5q MDS, because part of chromosome 5 is missing. In people with this disorder, the bone marrow does not produce enough healthy blood cells.

Lenalidomide may also be used for other purposes not listed in this medication guide.

Lenalidomide, a thalidomide analogue, is an immunomodulatory agent possessing immunomodulatory and antiangiogenic properties. Lenalidomide inhibits the secretion of pro-inflammatory cytokines and increases the secretion of anti-inflammatory cytokines from peripheral blood mononuclear cells. Lenalidomide inhibits cell proliferation with varying effectiveness (IC50s) in some but not all cell lines. Lenalidomide is effective in inhibiting growth of Namalwa cells (a human B cell lymphoma cell line with a deletion of one chromosome 5) but is much less effective in inhibiting growth of KG-1 cells (human myeloblastic cell line, also with a deletion of one chromosome 5) and other cell lines without chromosome 5 deletions.

Active ingredients: Lenalidomide
Unit description, dosagePrice, USD
Revlimid 25 mg capsule$ 411.71
Revlimid 15 mg capsule$ 407.70
Revlimid 10 mg capsule$ 406.05
Revlimid 5 mg capsule$ 388.00

List of lenalidomide brand and generic drugs

LENANGIO (India)
5 mg x 10's$ 27.78
10 mg x 10's$ 51.50
25 mg x 10's$ 137.04
LENID (India)
5 mg x 10's
10 mg x 10's
MYDOLEN (India)
10 mg x 10's$ 55.56
Revimid
Revlimid (Australia, Austria, Belgium, Denmark, France, Germany, Netherlands, Norway, Slovenia, Spain, Sweden, Switzerland, United Kingdom, United States)
Capsule; Oral; Lenalidomide 10 mg
Capsule; Oral; Lenalidomide 15 mg
Capsule; Oral; Lenalidomide 25 mg
Capsule; Oral; Lenalidomide 5 mg
Revlimid 5 mg x 21's
Revlimid 10 mg x 21's
Revlimid 15 mg x 21's
Revlimid 25 mg x 21's
100 capsule in 1 bottle
21 capsule in 1 bottle
25 capsule in 1 bottle
30 capsule in 1 bottle
Revlimid (Celgene)
 
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