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Lenisolone

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Lenisolone uses and description

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Lenisolone - Lenisolone is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Lenisolone restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Lenisolone contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Lenisolone inhibits the activity of fibroblasts and collagen formation.

Lenisolone inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.

Lenisolone reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.

Lenisolone inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.

Lenisolone has a vasoconstrictor effect with direct application to the vessels.

Lenisolone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Lenisolone enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.

Lenisolone inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.

Lenisolone also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Lenisolone affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.

In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.

When systemic use the therapeutic activity of Lenisolone is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local application the therapeutic activity of Lenisolone is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

As compared with hydrocortisone the anti-inflammatory activity of Lenisolone is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.

Indications: corticosteroid

Allergic conditions; collagen diseases (eg, systemic lupus erythematous, acute rheumatic carditis); dermatologic diseases; edematous states; endocrine conditions; GI diseases; hematologic diseases; neoplastic conditions; neoplastic diseases; nervous system conditions (eg, acute exacerbations of multiple sclerosis); ophthalmic conditions; conditions related to organ transplantation; pulmonary disease (eg, asthma); renal condition (eg, nephrotic syndrome); rheumatologic conditions; specific infectious diseases including trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concomitantly with appropriate antituberculous chemotherapy; tuberculosis with pleural or pericardial effusion. Treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Treatment of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Treatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).

Active ingredients: Prednisolone
Unit description, dosagePrice, USD

List of lenisolone brand and generic drugs

Kukje Prednisolone (Vietnam)
Kukje Prednisolone 5 mg x 1 Chai nhöïa 1000 Tablet
Lentosone
Lepicortinolo (Portugal)
Lidomex (South Korea)
Lidomex Kowa (Japan)
Linola H-Fett N (Czech Republic, Germany, Hungary)
Linola-H N (Germany)
Linola-H-Fett N
Cream; Topical; Prednisolone
Liquipred (Philippines)
Liquipred 15 mg/5 mL x 20 mL x 1's$ 3.39
Liquipred 15 mg/5 mL x 60 mL x 1's$ 7.48
Lite Pred
Longiprednil
Lygal Kopftinktur N
Lygal N (Germany)
M. B Sole
M. B Sole 1gm TAB / 10$ 22.04
M. B Sole 25mg TAB / 10
M. B Sole 40mg TAB / 10
Macrolone (Australia)
Mecortolon (Poland)
Medopred (Russian Federation)
Injectable; Injection; Prednisolone Sodium Phosphate 30 mg / ml
Megasolone (France)
Melpred INJ (India)
Melpred INJ 40mg VIAL / 1$ 1.93
Melpred INJ 125mg VIAL / 1$ 3.85
Melpred INJ 500mg VIAL / 1$ 8.67
40 mg x 1's$ 1.93
125 mg x 1's$ 3.85
500 mg x 1's$ 8.67
Metacortandralone
Meti-Derm
Cream; Topical; Prednisolone 0.5%
Meticortelone (Mexico, Venezuela)
Injectable; Injection; Prednisolone Acetate 25 mg / ml
Injectable; Injection; Prednisolone Sodium Phosphate 1 mg / ml
Injectable; Injection; Prednisolone Sodium Phosphate 3 mg / ml
Meticortelone Acetate (United States)
Microlone (Australia)
Microsolone (France)
Minims Prednisolone (Australia, Ireland, New Zealand, United Kingdom)
Minims Prednisolone (Single use) 0.5 % x 0.5 mL x 20's
Minims Prednisolone Sodium Phosphate (Oman, South Africa)
Solution; Ophthalmic; Prednisolone Sodium Phosphate 0.5%
Minims Prednisolone Sodium Phosphate 0.5 % x 0.5 mL x 20's
Minisolone (Myanmar)
Moxigram-P
Moxigram-P Moxifloxacin 0.5 % w/v,Prednisolone 1 % w/v. EYE-DPS / 5ml$ 0.25
MPSS Baceteriostatic Water
MPSS Baceteriostatic Water 1g VIAL / 1$ 22.20
MPSS Baceteriostatic Water 500mg VIAL / 1$ 12.94

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