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Levonat

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Levonat uses and description

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Levonat - Pharmacology: Interferes with microbial DNA synthesis.

Indication: Treatment of acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis, acute pyelonephritis, anthrax (inhalational, postexposure), chronic bacterial prostatitis, community-acquired pneumonia, complicated and uncomplicated skin and skin-structure infections, complicated and uncomplicated UTI, and nosocomial pneumonia caused by susceptible strains of specific microorganisms.

Ophthalmic use

Treatment of conjunctivitis caused by susceptible strains of aerobic gram-positive and aerobic gram-negative microorganisms.

Unlabeled Uses

Disseminated gonococcal infections; traveler's diarrhea.

Levonat, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levonat is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.

Oral Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute bacterial exacerbation of chronic bronchitis

Adult: 500 mg once daily for 7 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Complicated skin and skin structure infections

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated urinary tract infections

Adult: 250 mg once daily for 3 days. Oral Complicated urinary tract infections

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Uncomplicated skin and skin structure infections

Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute bacterial exacerbation of chronic bronchitis

Adult: 500 mg once daily for 7 days. Infuse slowly over 60 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Complicated skin and skin structure infections

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated urinary tract infections

Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated urinary tract infections

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Uncomplicated skin and skin structure infections

Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections

Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Levonat is an antibiotic. It is used to treat certain bacterial infections of the nose, lungs, skin, genitals and bladder. Levonat belongs to a group of antibiotics called the quinolones.

Oral Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute exacerbations of chronic bronchitis

Adult: 250-500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Skin and skin structure infections, complicated

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated UTI

Adult: 250 mg once daily for 3 days. Oral Complicated UTI

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Skin and skin structure infections, uncomplicated

Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute exacerbations of chronic bronchitis

Adult: 250-500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Skin and skin structure infections, complicated

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated UTI

Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated UTI

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Skin and skin structure infections, uncomplicated

Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections caused by susceptible organisms

Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Oral Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute bacterial exacerbation of chronic bronchitis

Adult: 500 mg once daily for 7 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Complicated skin and skin structure infections

Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated urinary tract infections

Adult: 250 mg once daily for 3 days. Oral Complicated urinary tract infections

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis

Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Uncomplicated skin and skin structure infections

Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis

Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute bacterial exacerbation of chronic bronchitis

Adult: 500 mg once daily for 7 days. Infuse slowly over 60 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia

Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Complicated skin and skin structure infections

Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated urinary tract infections

Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated urinary tract infections

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis

Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Uncomplicated skin and skin structure infections

Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis

Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax

Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections

Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days. Special Populations: For patients with CrCl of 20-49 mL/min, the initial dose of 500 mg is administered followed by 250 mg once daily. If CrCl is 10-19 mL/min, the initial dose of 500 mg is administered followed by 250 mg every 48 hours. Reduce dose in patients with renal impairment.

Indications:

Adult: PO/IV Acute sinusitis 500 mg once daily for 10-14 days. Acute bacterial exacerbation of chronic bronchitis 500 mg once daily for 7 days. Community-acquired pneumonia 500 mg once daily for 7-14 days. Uncomplicatd skin infections 500 mg once daily for 7-10 days. Nosocomial pneumonia ; Complicated skin infections 750 mg once daily for 7-14 days. Uncomplicated UTI 250 mg once daily for 3 days. Acute pyelonephritis ; Complicated UTI 250 mg once daily for 10 days. Chronic bacterial prostatitis 500 mg once daily for 28 days. Treatment and postexposure prophylaxis of inhalation anthrax 500 mg once daily for 60 days. Ophth Ocular infections As 0.5% soln: Instill 1-2 drops 2 hrly while awake (up to 8 times/day) for 2 days, then 1-2 drops 4 hrly while awake (up to 4 times/day) for 5 days.

Acute maxillary sinusitisAcute bacterial exacerbation of chronic bronchitisCommunity acquired pneumonia due to typical or atypical bacteriaHospital acquired pneumonia (Nosocomial pneumonia) Complicated or uncomplicated skin and skin structure infections e.g. abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections. Complicated or uncomplicated urinary tract infectionsUpper UTI e.g. acute pyelonephritisLower UTI e.g. urethritis, cystitis or prostatitisTyphoid fever and other enteric infections, Eye Infections

Active ingredients: Levofloxacin
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