Levoquinox - Pharmacology: Interferes with microbial DNA synthesis.
Indication: Treatment of acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis, acute pyelonephritis, anthrax (inhalational, postexposure), chronic bacterial prostatitis, community-acquired pneumonia, complicated and uncomplicated skin and skin-structure infections, complicated and uncomplicated UTI, and nosocomial pneumonia caused by susceptible strains of specific microorganisms.
Ophthalmic use
Treatment of conjunctivitis caused by susceptible strains of aerobic gram-positive and aerobic gram-negative microorganisms.
Unlabeled Uses
Disseminated gonococcal infections; traveler's diarrhea.
Levoquinox, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levoquinox is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.
Oral Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days. Oral Complicated urinary tract infections
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days. Infuse slowly over 60 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated urinary tract infections
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections
Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Levoquinox is an antibiotic. It is used to treat certain bacterial infections of the nose, lungs, skin, genitals and bladder. Levoquinox belongs to a group of antibiotics called the quinolones.
Oral Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute exacerbations of chronic bronchitis
Adult: 250-500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Skin and skin structure infections, complicated
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated UTI
Adult: 250 mg once daily for 3 days. Oral Complicated UTI
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Skin and skin structure infections, uncomplicated
Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute exacerbations of chronic bronchitis
Adult: 250-500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Skin and skin structure infections, complicated
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated UTI
Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated UTI
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Skin and skin structure infections, uncomplicated
Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections caused by susceptible organisms
Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Oral Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Oral Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Oral Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days. Oral Complicated urinary tract infections
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Acute pyelonephritis
Adult: 250 mg once daily for 10 days. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Oral Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Oral Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days. Infuse slowly over 60 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 750 mg daily, then 500 mg every 48 hr. Intravenous Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min. Intravenous Complicated urinary tract infections
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Acute pyelonephritis
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 10-19 Initially 250 mg daily, then 250 mg every 48 hr. Intravenous Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Intravenous Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min. Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min. CrCl (ml/min) Dosage Recommendation 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Ophthalmic Ocular infections
Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days. Special Populations: For patients with CrCl of 20-49 mL/min, the initial dose of 500 mg is administered followed by 250 mg once daily. If CrCl is 10-19 mL/min, the initial dose of 500 mg is administered followed by 250 mg every 48 hours. Reduce dose in patients with renal impairment.
Indications:
Adult: PO/IV Acute sinusitis 500 mg once daily for 10-14 days. Acute bacterial exacerbation of chronic bronchitis 500 mg once daily for 7 days. Community-acquired pneumonia 500 mg once daily for 7-14 days. Uncomplicatd skin infections 500 mg once daily for 7-10 days. Nosocomial pneumonia ; Complicated skin infections 750 mg once daily for 7-14 days. Uncomplicated UTI 250 mg once daily for 3 days. Acute pyelonephritis ; Complicated UTI 250 mg once daily for 10 days. Chronic bacterial prostatitis 500 mg once daily for 28 days. Treatment and postexposure prophylaxis of inhalation anthrax 500 mg once daily for 60 days. Ophth Ocular infections As 0.5% soln: Instill 1-2 drops 2 hrly while awake (up to 8 times/day) for 2 days, then 1-2 drops 4 hrly while awake (up to 4 times/day) for 5 days.
Acute maxillary sinusitisAcute bacterial exacerbation of chronic bronchitisCommunity acquired pneumonia due to typical or atypical bacteriaHospital acquired pneumonia (Nosocomial pneumonia) Complicated or uncomplicated skin and skin structure infections e.g. abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections. Complicated or uncomplicated urinary tract infectionsUpper UTI e.g. acute pyelonephritisLower UTI e.g. urethritis, cystitis or prostatitisTyphoid fever and other enteric infections, Eye Infections |
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