Lexamil - Lexamil is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Lexamil affects chemicals in the brain that may become unbalanced and cause depression or anxiety.
Lexamil is used to treat anxiety in adults and major depressive disorder in adults and adolescents who are at least 12 years old.
Lexamil may also be used for other purposes not listed in this medication guide.
Lexamil is an antidepressant. This medication selectively inhibits the reuptake of serotonin, increases the concentration of the neurotransmitter in the synaptic cleft, prolongs and enhances the action of serotonin on postsynaptic receptors. Lexamil practically does not bind to serotonin (5-HT), dopamine (D1 and D2) receptors, alpha-adrenergic-, m-cholinergic receptors, with benzodiazepine and opioid receptors.
Antidepressant effect of this drug is usually develops within 2-4 weeks after starting treatment. The maximum therapeutic effect of the treatment of panic disorder is reached at about 3 months after starting treatment.
Lexamil is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Lexamil are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Lexamil is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Lexamil has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Lexamil was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Lexamil does not inhibit monoamine oxidase.
Lexamil is used to treat depression. It can also be used to treat anxiety disorders such as panic disorder, social anxiety disorder or obsessive-compulsive disorder (OCD). Lexamil belongs to a group of antidepressants known as Selective Serotonin Re-uptake Inhibitors (SSRIs).
Oral Depression
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Obsessive compulsive disorder
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Anxiety
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Panic disorder
Adult: Initially, 5 mg daily, increased to 10 mg daily after 7 days. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required.
Indications:
Adult: PO Depression ; Anxiety ; Obsessive compulsive disorder 10 mg once daily. Max: 20 mg/day. Panic disorder Initial: 5 mg/day, up to 10 mg/day after 7 days if needed. Max: 20 mg/day.
Oral Depression
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Obsessive compulsive disorder
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Anxiety
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Panic disorder
Adult: Initially, 5 mg daily, increased to 10 mg daily after 7 days. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Special Populations: Patients with hepatic impairment: 5 mg daily. May increase to 10 mg daily after 2 wk.
Oral Depression
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Generalised anxiety disorder
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Obsessive compulsive disorder
Adult: 10 mg once daily, increased if necessary. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. Oral Panic disorder
Adult: Initially, 5 mg daily, increased to 10 mg daily after 7 days. Max: 20 mg daily.
Elderly: Half the adult dose. Hepatic impairment: Dosage adjustments may be required. |
brand and generic drugs
