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Lioresal

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Lioresal uses and description

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Lioresal - Lioresal is a muscle relaxer and an antispastic agent.

Lioresal is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

Lioresal may also be used for purposes not listed in this medication guide.

Used for: Treating severe muscle spasms due to a variety of causes, including brain or spinal cord injuries.

Lioresal is a muscle relaxant and antispastic agent. It reduces the frequency and severity of muscle spasms that occur as a result of neurological disorders, such as multiple sclerosis.

Lioresal is centrally acting muscle relaxant; GABA-receptor agonist. It depresses mono-and polysynaptic reflexes presumably by reducing the release of excitatory amino acids (glutamate and aspartate) from the terminals which occurs as a result of stimulation of presynaptic GABA-receptors. This medication does not affect the transmission of impulses in the nerve-muscle synapses; reduces skeletal muscle tone; has a moderate analgesic effect.

Lioresal is a muscle relaxant and antispastic. Lioresal is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Lioresal is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Lioresal has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Lioresal is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Lioresal is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Indication: For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Lioresal (brand names Kemstro and Lioresal) is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity. It is an agonist specific to mammalian but not fruit fly (Drosophila) GABAB receptors. Its beneficial effects result from actions at spinal and supraspinal sites. Lioresal can also be used to treat hiccups. It has been shown to prevent rises in body temperature induced by the drug MDMA in rats. A very beneficial property of Lioresal is that tolerance does not seem to occur to any significant degree in that Lioresal retains its therapeutic anti-spasmodic effects even after many years of chronic use.

Lioresal INTRATHECAL is indicated for use in the management of severe spasticity. Patients should first respond to a screening dose of intrathecal Lioresal prior to consideration for long term infusion via an implantable pump. For spasticity of spinal cord origin, chronic infusion of Lioresal INTRATHECAL via an implantable pump should be reserved for patients unresponsive to oral Lioresal therapy, or those who experience intolerable CNS side effects at effective doses. Patients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal Lioresal therapy. Lioresal INTRATHECAL (baclofen injection) is intended for use by the intrathecal route in single bolus test doses (via spinal catheter or lumbar puncture) and, for chronic use, only in implantable pumps approved by the FDA specifically for the administration of Lioresal INTRATHECAL into the intrathecal space. Spasticity of Spinal Cord Origin:

Indications: skeletal muscle spasm or spasticity

Lioresal is used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain due to multiple sclerosis.

Spasticity of the skeletal muscles in multiple sclerosis. Spastic conditions occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic or unknown origin eg, spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis and compression of the spinal cord; muscle spasm of cerebral origin, especially where due to infantile cerebral palsy, as well as following cerebrovascular accidents or in the presence of neoplastic or degenerative brain disease.

Active ingredients: Baclofen
Unit description, dosagePrice, USD
Injectable; Intrathecal; Baclofen 0.05 mg / ml
Injectable; Intrathecal; Baclofen 0.5 mg / ml
Injectable; Intrathecal; Baclofen 2 mg / ml
Liquid; Oral; Baclofen 5 mg / 5 ml
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg
Tablet; Oral; Baclofen 25 mg
LIORESAL Capsule/ Tablet / 10mg (10 units)$ 2.05
LIORESAL Capsule/ Tablet / 20mg (10 units)$ 2.67
Lioresal 10 mg x 50's$ 32.08
Lioresal 10mg TAB / 30$ 3.33
Lioresal 25mg TAB / 30$ 6.94
10 mg x 30's$ 3.33
25 mg x 30's$ 6.94
Lioresal 10 mg x 20 x 10's
1 milliliter in 1 ampule
20 milliliter in 1 ampule
5 milliliter in 1 ampule
Injectable; Injection; Baclofen 0.05 mg / ml
Injectable; Injection; Baclofen 0.5 mg / ml
Injectable; Injection; Baclofen 2 mg / ml
Tablets; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 25 mg

List of lioresal brand and generic drugs

Liorel (Bangladesh)
Lioresal D.S.
Tablet; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 20 mg
Lioresal Intratecal (Spain)
Lioresal Intrathekal
Injectable; Intrathecal; Baclofen 0.05 mg / ml
Injectable; Intrathecal; Baclofen 0.5 mg / ml
Injectable; Intrathecal; Baclofen 2 mg / ml
Lioresyl (Chile)
Tablet; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 10 mg
Liosal (Bangladesh)
Liotec
Lyflex (United Kingdom)
Solution; Oral; Baclofen 5 mg / 5 ml
Maclofen (Taiwan)
Maclofen 10 mg
Maclofen 10 mg x Blister pk
Med Baclofen
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 20 mg
Miorel (France, Greece)
Capsule; Oral; Thiocolchicoside 4 mg
Injectable; Injection; Thiocolchicoside 2 mg / ml
Mulax (Taiwan)
Mulax 10 mg x 500's
Mulax (Orange-flavored sachet) 7 g x 10's$ 4.08
Muscofen (Taiwan)
Muscofen 10 mg
Mylan-Baclofen
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 20 mg
Neurospas (India)
NEUROSPAS Capsule/ Tablet / 20mg - 500mg (10 units)$ 0.22
100's$ 2.17
Neurospas 15 ml Drop$ 0.35
Neurospas 500 mg+20 mg Capsule$ 0.02
Neurospas Dicyclomine hydrochloride 20mg, Acetaminophen 500 mg. CAP / 100$ 2.17
Novo-Baclofen
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 20 mg
Nu-Baclo
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg
Tablets; Oral; Baclofen 10 mg
Tablets; Oral; Baclofen 20 mg
Nu-Baclofen
Tablet; Oral; Baclofen 10 mg
Tablet; Oral; Baclofen 20 mg

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