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Locoidon

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Locoidon uses and description

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Locoidon - Glucocorticosteroid. Inhibits the function of leukocytes and tissue macrophages. The migration of leukocytes in the area of inflammation. Impair the capacity of macrophages to phagocytosis and the formation of interleukin-1. Contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the field of inflammation. Decreases capillary permeability due to histamine release. Inhibits activity of fibroblasts and collagen formation.

Inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce production of prostaglandins.

Reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the vascular bed to lymphoid tissue, suppresses the formation of antibodies.

Locoidon suppresses the release of pituitary ACTH and beta-lipotropin but does not reduce the level of circulating beta-endorphin. Inhibits the secretion of TSH and FSH.

With direct application of the receptacles has a vasoconstrictor effect.

Locoidon has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the capture of amino acids by the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver of Locoidon increases glycogen deposition by stimulating the activity of glycogen synthase and synthesis of glucose from the products of protein metabolism. Increased blood glucose activates the secretion of insulin.

Locoidon suppresses the seizure of glucose by fat cells that leads to activation of lipolysis. However, due to increased secretion of insulin is stimulation of lipogenesis which leads to the accumulation of fat.

This medication has catabolic effect in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue; to a lesser extent than the mineralocorticoid affects the processes of water and electrolyte metabolism: promotes the excretion of potassium ions and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing\'s syndrome are the main factors limiting the long-term therapy of GCS. As a result of catabolic actions may suppress growth in children.

In high doses Locoidon may increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. It stimulates the excessive production of hydrochloric acid and pepsin in the stomach that promotes the development of peptic ulcers.

For systems use therapeutic activity of Locoidon caused by anti-inflammatory, anti-allergic, immunosuppressive and antiproliferative action. When external and local application the therapeutic activity of Locoidon is due to anti-inflammatory, anti-allergic and antiexudative (due to vasoconstrictor effect) action. For anti-inflammatory activity this medicine is 4 times weaker than prednisolone, at mineralocorticoid activity is superior to other GCS.

Indications: skin disorders

This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Locoidon butyrate reduces the swelling, itching, and redness that can occur in these types of conditions. The topical solution is used to treat severe dandruff (seborrheic dermatitis). This medication is a medium-strength corticosteroid.

Locoidon is a glucocorticosteroid. Locoidon inhibits the function of leukocytes and tissue macrophages. The migration of leukocytes in the area of inflammation. Impair the capacity of macrophages to phagocytosis and the formation of interleukin-1. Contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the field of inflammation. Decreases capillary permeability due to histamine release. Inhibits activity of fibroblasts and collagen formation.

Active ingredients: Hydrocortisone
Unit description, dosagePrice, USD

List of locoidon brand and generic drugs

Locoid Skalp-Lotio
Solution; Topical; Hydrocortisone Butyrate 0.1%
Lubricort
Lycor (Ethiopia)
1 % w/w x 15g$ 1.00
Lycor 1% w/w CRM / 15g$ 1.00
LYCOR CREAM
LYCOR CREAM Cream/ Gel/ Ointment / 1(%) (15gm units)$ 0.93
LYCORTIN - S
LYCORTIN - S Injection / 100mg (1 units)$ 0.81
Lycortin-S (India)
Lycortin-S 100mg VIAL / 3ml$ 0.81
Lycortin-S 200mg VIAL / 5ml$ 1.46
100 mg x 3ml$ 0.81
200 mg x 5ml$ 1.46
Lyo-Cortin (Greece)
M Hydrocortisone (New Zealand)
Maintasone
Martindale Hydrocortisone (Hongkong)
Martindale Hydrocortisone 1 % x 3 g
Massengill Medicated Soft Cloth Towelette
Massengill Towelette (United States)
Medrocil (Argentina)
Meusicort
Micort-HC (United States)
Cream; Topical; Hydrocortisone Acetate 2%
Cream; Topical; Hydrocortisone Acetate 2.5%
28.4 gram in 1 tube
Microsona (Argentina, Mexico)
Cream; Topical; Hydrocortisone 0.5%
Cream; Topical; Hydrocortisone 1%
Cream; Topical; Hydrocortisone 2%
Mildison (United Kingdom)
Cream; Topical; Hydrocortisone 1%
Mildison Lipid (Denmark, Iceland, Norway, Sweden)
Mildison Lipocream (United Kingdom)
Cream; Topical; Hydrocortisone 1%
Milliderm
Mitocortyl (France)
Mitocortyl Demangeaisons
Cream; Topical; Hydrocortisone 0.5%
Muni (Germany)
Muni 20 g
Muni HC (Germany)
Munitren H
Ointment, Fatty; Topical; Hydrocortisone
Ointment; Topical; Hydrocortisone
Mycort
Mycort 100mg VIAL / 1$ 1.11
Mylocort (South Africa)
Neo-HC
Cream; Topical; Hydrocortisone Acetate 2%
Neopolygramin H
Neopolygramin H Skin 3 gm Ointment$ 0.09
Neosporin-H Ear
Neuroderm Akut (Germany)
Neutrogena T / Scalp
Niscort (India)
Niscort - VIAL / 1$ 0.78

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