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Melanil

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Melanil uses and description

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Melanil - Used for: Preventing or treating malaria.

Melanil is an antiprotozoal and antimalarial. It works by interfering with the development of malaria parasites.

Melanil and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

The combination of Melanil and proguanil is used to treat or prevent malaria.

Melanil and proguanil may also be used for purposes not listed in this medication guide.

Melanil is a highly lipophilic drug that closely resembles the structure ubiquinone. Its inhibitory effect being comparable to ubiquinone, in sensitive parasites Melanil can act by selectively affecting mitochondrial electron transport and parallel processes such as ATP and pyrimidine biosynthesis. For illustration, cytochrome bc1 complex (complex III) seems to serve as a highly discriminating molecular target for Melanil in Plasmodia

Melanil has the advantage of not causing myelosuppression, which is an important issue in patients who have undergone bone marrow transplantation.

Indication: For the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.

This medicine contains Melanil and Proguanil. This combination of Melanil and Progunail is used for the treatment and prevention of malaria.

Prophylaxis of Plasmodium falciparum malaria. Treatment of acute, uncomplicated Plasmodium falciparum malaria. Because Melanil is effective against drug sensitive and drug resistant P. falciparum, it is especially recommended for prophylaxis and treatment of P. falciparum malaria where the pathogen may be resistant to other antimalarials. Official guidelines and local information on the prevalence of resistance to antimalarial drugs should be taken into consideration. Official guidelines will normally include WHO and public health authorities guidelines.

Prophylaxis and treatment of Plasmodium falciparum malaria. Because Melanil is effective against drug-sensitive and drug-resistant P. falciparum, it is especially recommended for prophylaxis and treatment of P. falciparum malaria in areas where the pathogen may be resistant to other antimalarials. Official guidelines and local information on the prevalence of resistance to antimalarial drugs should be taken into consideration. Official guidelines will normally include WHO and public health authorities guidelines.

Indications: malaria

Prevention of MalariaMALARONE is indicated for the prophylaxis of P. falciparum malaria, including in areas where chloroquine resistance has been reported. Treatment of MalariaMALARONE is indicated for the treatment of acute, uncomplicated P. falciparum malaria. Melanil has been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance.

Acute treatment of mild to moderate Pneumocystis carinii pneumonia (PCP) (difference ofalveolar and arterial oxygen tensions [(A-a) DO2] ≤45 mmHg (6 kPa) and oxygen tension inarterial blood (Pa02) ≥60 mmHg (8 kPa) breathing room air) in adult patients with AIDS whoare intolerant of trimethoprim/sulphamethoxazole therapy. CONTRA-

Active ingredients: Atovaquone/Proguanil
Unit description, dosagePrice, USD

List of melanil brand and generic drugs

Atovaquone/Proguanil (Australia, Austria, Belgium, Canada, Denmark, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Ireland, Italy, Lithuania, Luxembourg, Malaysia, Netherlands, New Zealand, Norway, Singapore, Slovenia, Spain, Sweden, Switzerland, United Kingdom, United States)
Malanil (Thailand)
Malanil 12's
Malanil 150mg x 2mL INJ / 2ml$ 2.04
Malarone (Australia, Austria, Belgium, Canada, Denmark, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Ireland, Italy, Lithuania, Luxembourg, Malaysia, Netherlands, New Zealand, Norway, Singapore, Slovenia, Spain, Sweden, Switzerland, United Kingdom, United States)
Tablet, Film-Coated; Oral; Atovaquone 62.5 mg; Proguanil Hydrochloride 25 mg
Tablet, Film-Coated; Oral; Atovaquone 250 mg; Proguanil Hydrochloride 100 mg
Tablet; Oral; Atovaquone 250 mg; Proguanil Hydrochloride 100 mg
100 tablet in 1 bottle
24 tablet in 1 dose pack
Malarone 12's
Malarone Adults
Tablet; Oral; Atovaquone 250 mg; Proguanil Hydrochloride 100 mg
Malarone Bambini (Italy)
Malarone Junior (Australia, Belgium, Canada, Germany, Norway, Sweden, Switzerland)
Tablet; Oral; Atovaquone 62.5 mg; Proguanil Hydrochloride 25 mg
Malarone Paediatric (Greece, United Kingdom)
Tablet; Oral; Atovaquone 62.5 mg; Proguanil Hydrochloride 25 mg
Malarone Pediatrico
Tablet; Oral; Atovaquone 250 mg; Proguanil Hydrochloride 100 mg
Malarone Pediatrico Comp
Tablet; Oral; Atovaquone 250 mg; Proguanil Hydrochloride 100 mg
Promal
 
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